Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) Cardiovascular Outcomes Study (MK-0616-015) CORALreef Outcomes
Phase 3 Randomized, Placebo-Controlled Clinical Study to Evaluate the Efficacy and Safety of MK-0616 in Reducing Major Adverse Cardiovascular Events in Participants at High Cardiovascular Risk
4 other identifiers
interventional
14,550
29 countries
669
Brief Summary
This is a phase 3, randomized, placebo-controlled study of the efficacy and safety of enlicitide decanoate, an oral proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, in participants with high cardiovascular risk. The primary objective is to evaluate the efficacy of enlicitide decanoate compared with placebo in increasing the time to the first occurrence of major adverse cardiovascular events (MACE) including coronary heart disease (CHD) death, ischemic stroke, myocardial infarction (MI), acute limb ischemia or major amputation, or urgent arterial revascularization.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Oct 2023
Longer than P75 for phase_3
669 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 17, 2023
CompletedFirst Posted
Study publicly available on registry
August 24, 2023
CompletedStudy Start
First participant enrolled
October 9, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 29, 2029
ExpectedStudy Completion
Last participant's last visit for all outcomes
November 29, 2031
April 23, 2026
April 1, 2026
6.1 years
August 17, 2023
April 20, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Blinded Period: Time to First Occurrence of Coronary Heart Disease (CHD) Death-Based Major Adverse Cardiovascular Events (MACE)-Plus
Time to the first occurrence of CHD death-based MACE-plus, which is defined as any of the following: coronary heart disease death, myocardial infarction (MI), ischemic stroke (fatal and nonfatal), acute limb ischemia or major amputation, or urgent arterial revascularization (coronary, cerebrovascular, or peripheral).
From date of randomization until the date of first occurrence of CHD death-based MACE-plus, assessed up to approximately 6 years
Secondary Outcomes (17)
Blinded Period: Time to First Occurrence of 3-point MACE
From date of randomization until the date of first occurrence of 3-point MACE, assessed up to approximately 6 years
Blinded Period: Time to First Occurrence of Cardiovascular (CV) Death-Based MACE Plus
From date of randomization until the date of first occurrence of CV death-based MACE plus, assessed up to approximately 6 years
Blinded Period: Time to First Occurrence of CHD Death or MI
From date of randomization until the date of first occurrence of CHD death or MI, assessed up to approximately 6 years
Blinded Period: Time to CV Death
From date of randomization until the date of CV death, assessed up to approximately 6 years
Blinded Period: Time to All-Cause Death
From date of randomization until the date of death, assessed up to approximately 6 years
- +12 more secondary outcomes
Study Arms (3)
Blinded Portion: Enlicitide Decanoate
EXPERIMENTALParticipants receive enlicitide decanoate 20 mg once daily.
Blinded Portion: Placebo
PLACEBO COMPARATORParticipants receive placebo once daily.
Open-Label Extension: Enlicitide Decanoate
EXPERIMENTALParticipants who complete the blinded portion may enroll in this open-label extension arm. Participants in the extension arm receive enlicitide decanoate once daily up to 2 years.
Interventions
Enlicitide Decanoate 20 mg tablet taken by mouth.
Eligibility Criteria
You may qualify if:
- Meets one of the following:
- Age ≥18 years with a history of a major atherosclerotic cardiovascular disease (ASCVD) event defined as at least 1 of the following: ≥30 days post MI (presumed Type 1 due to plaque rupture or erosion); ≥30 days post ischemic stroke (presumed due to atherosclerosis); or ≥30 days post successful peripheral (carotid or lower extremity) arterial revascularization (surgical or endovascular) or major (ankle or above) amputation due to atherosclerosis; or
- High risk for first major ASCVD event defined as at least 1 of the following: Age ≥50 years with evidence of coronary artery disease; Age ≥50 years with evidence of atherosclerotic cerebrovascular disease; Age ≥50 years with evidence of peripheral arterial disease; or Age ≥60 years with diabetes mellitus and at least one of the following: microvascular disease or urine albumin-creatinine ratio ≥30 mg/mmol within 6 months before Visit 1, daily insulin use, or diabetes for ≥10 years
- Has fasted lipid values (evaluated by the Central Laboratory) at Visit 1 (Screening) as follows:
- History of major ASCVD Event: LDL-C ≥70 mg/dL (1.81 mmol/L) OR non-HDL-C ≥100 mg/dL (2.59 mmol/L)
- High risk for first major ASCVD Event: LDL-C ≥90 mg/dL (2.33 mmol/L) OR non-HDL-C ≥120 mg/dL (3.11 mmol/L)
- Is treated with moderate- or high-intensity statin (± nonstatin lipid-lowering therapy \[LLT\]) at Visit 1
- Is on a stable dose of all background LLTs (including statin and nonstatin agents) for at least 30 days before Visit 1 (Screening) with no medication or dose changes planned during the participation in the study
You may not qualify if:
- Has a history of homozygous familial hypercholesterolemia (FH) based on genetic or clinical criteria, compound heterozygous FH, or double heterozygous FH
- Has New York Heart Association Class IV heart failure, last known Left Ventricular Ejection Fraction ≤25% by any imaging method, or had a Heart Failure hospitalization within 3 months before Visit 1 (Screening)
- Has recurrent ventricular tachycardia within 3 months prior to randomization
- Has a planned arterial revascularization procedure
- Is undergoing or previously underwent an LDL-C apheresis program within 3 months before Visit 1 (Screening) or plans to initiate an LDL-C apheresis program
- Was previously treated/is being treated with certain other cholesterol lowering medications, including protein convertase subtilisin/kexin type 9 (PCSK9) inhibitors without adequate washout.
- Has a fasting triglyceride value ≥400 mg/dL (≥4.52 mmol/L) at Visit 1 (Screening)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (669)
Advanced Cardiovascular - Alexander City ( Site 0156)
Alexander City, Alabama, 35010, United States
Central Research Associates ( Site 0118)
Birmingham, Alabama, 35205, United States
St. Vincent's Birmingham Hospital ( Site 0181)
Birmingham, Alabama, 35205, United States
Central Alabama Research ( Site 0109)
Birmingham, Alabama, 35209, United States
Alliance for Multispecialty Research, LLC ( Site 0076)
Daphne, Alabama, 36526, United States
G&L Research ( Site 0042)
Foley, Alabama, 36535, United States
NextStage Clinical Research - Phoenix - (01) ( Site 0191)
Glendale, Arizona, 85306, United States
Synexus Clinical Research US, Inc.-Synexus Clinical Research US, Inc - Central Phoenix ( Site 0066)
Phoenix, Arizona, 85020, United States
Medical Investigations Inc. ( Site 0188)
Little Rock, Arkansas, 72211, United States
National Heart Institute-Research ( Site 0077)
Beverly Hills, California, 90211, United States
UCSD - Altman Clinical and Translational Research Institute (ACTRI) ( Site 0130)
La Jolla, California, 92037, United States
Chemidox Clinical Trials ( Site 0145)
Lancaster, California, 93534, United States
Velocity Clinical Research, Westlake ( Site 0039)
Los Angeles, California, 90057, United States
Carbon Health - Pasadena ( Site 0149)
Pasadena, California, 91101, United States
Carbon Health - San Mateo - Hillsdale Mall ( Site 0151)
San Mateo, California, 94403, United States
America Clinical Trials-Research Dept ( Site 0104)
Tarzana, California, 91356-3551, United States
Premiere Medical Center ( Site 0093)
Toluca Lake, California, 91602, United States
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center ( Site 0058)
Torrance, California, 90502, United States
University of Colorado Anschutz Medical Campus-University of Colorado Hospital Cardiac and Vascular ( Site 0146)
Aurora, Colorado, 80045, United States
South Denver Cardiology Associates ( Site 0167)
Littleton, Colorado, 80120, United States
Cardiology Associates of Fairfield County, P.C. ( Site 0159)
Stamford, Connecticut, 06905, United States
Chase Medical Research, LLC ( Site 0046)
Waterbury, Connecticut, 06708, United States
Emerson Clinical Research Institute ( Site 0143)
Washington D.C., District of Columbia, 20009, United States
Excel Medical Clinical Trials ( Site 0052)
Boca Raton, Florida, 33434, United States
Advanced Pharma Research ( Site 0040)
Cutler Bay, Florida, 33189, United States
Alliance for Multispecialty Research, LLC ( Site 0083)
Fort Myers, Florida, 33912, United States
Westside Center for Clinical Research ( Site 0049)
Jacksonville, Florida, 32205, United States
University of Florida - Jacksonville ( Site 0166)
Jacksonville, Florida, 32209, United States
East Coast Institute for Research, LLC ( Site 0031)
Jacksonville, Florida, 32216, United States
Jacksonville Center for Clinical Research ( Site 0048)
Jacksonville, Florida, 32216, United States
East Coast Institute for Research ( Site 0034)
Lake City, Florida, 32055, United States
Columbus Clinical Services ( Site 0026)
Miami, Florida, 33125, United States
Miami Cardiac & Vascular Institute-Ambulatory Research ( Site 0059)
Miami, Florida, 33173, United States
Inpatient Research Clinic ( Site 0041)
Miami Lakes, Florida, 33014, United States
Eminat ( Site 0082)
Miramar, Florida, 33027, United States
Ocala Research Institute - Ocala - Southwest 20th Place ( Site 0079)
Ocala, Florida, 34471, United States
Progressive Medical Research ( Site 0045)
Port Orange, Florida, 32127, United States
St Johns Center for Clinical Research ( Site 0016)
Saint Augustine, Florida, 32086, United States
Clinical Site Partners LLC, dba CSP Orlando ( Site 0067)
Winter Park, Florida, 32789, United States
The Jones Center Clinical Research ( Site 0032)
Macon, Georgia, 31210, United States
North Georgia Clinical Research ( Site 0128)
Woodstock, Georgia, 30189, United States
Bingham Memorial Hospital ( Site 0195)
Blackfoot, Idaho, 83221, United States
Synexus Clinical Research US, Inc. ( Site 0084)
Chicago, Illinois, 60602, United States
Great Lakes Clinical Trials - Ravenswood ( Site 0056)
Chicago, Illinois, 60640, United States
Great Lakes Clinical Trials - Gurnee ( Site 0134)
Gurnee, Illinois, 60031, United States
Alliance for Multispecialty Research, LLC ( Site 0173)
Park Ridge, Illinois, 60068, United States
Healthcare Research Network - Chicago ( Site 0051)
Tinley Park, Illinois, 60477, United States
Alliance for Multispecialty Research - Medisphere Medical Research Center ( Site 0080)
Evansville, Indiana, 47714, United States
Parkview Research Center at Parkview Regional Medical Center ( Site 0154)
Fort Wayne, Indiana, 46845, United States
Franciscan Physician Network - Indiana Heart Physicians ( Site 0141)
Indianapolis, Indiana, 46237, United States
Reid Physician Associates ( Site 0174)
Richmond, Indiana, 47374, United States
University of Kansas Medical Center ( Site 0004)
Kansas City, Kansas, 66160, United States
Cotton O'Neil Clinical Research Center ( Site 0095)
Topeka, Kansas, 66606, United States
AMR Clinical - Wichita ( Site 0116)
Wichita, Kansas, 67226, United States
Alliance for Multispecialty Research, LLC ( Site 0027)
Lexington, Kentucky, 40509, United States
L-MARC Research Center ( Site 0001)
Louisville, Kentucky, 40213, United States
Avant Research Associates ( Site 0103)
Crowley, Louisiana, 70526, United States
IMA Clinical Research- Monroe- North 18th Street ( Site 0111)
Monroe, Louisiana, 71201, United States
Northeast Cardiology Associates ( Site 0168)
Bangor, Maine, 04401, United States
Flourish Research - Bowie ( Site 0190)
Bowie, Maryland, 20715, United States
Centennial Medical Group ( Site 0179)
Columbia, Maryland, 21045, United States
Brigham and Women's Hospital-Cardiovascular Medicine ( Site 0147)
Boston, Massachusetts, 02115, United States
Boston Clinical Trials ( Site 0029)
Boston, Massachusetts, 02131, United States
Alliance for Multispecialty Research, LLC. ( Site 0171)
Dearborn, Michigan, 48126, United States
Healthy Heart Cardiology ( Site 0113)
Grand Rapids, Michigan, 49546, United States
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division ( Site 0003)
Troy, Michigan, 48098, United States
Trinity Health-Michigan d/b/a Michigan Heart ( Site 0186)
Ypsilanti, Michigan, 48197, United States
Fairview Health Services ( Site 0024)
Maplewood, Minnesota, 55109, United States
Abbott Northwestern Hospital ( Site 0199)
Minneapolis, Minnesota, 55407, United States
University of Minnesota, Lillehei Clinical Research Unit ( Site 0193)
Minneapolis, Minnesota, 55455, United States
Velocity Clinical Research, Gulfport ( Site 0038)
Gulfport, Mississippi, 39503, United States
Cardiology Associates of North Mississippi ( Site 0169)
Tupelo, Mississippi, 38801, United States
Healthcare Research Network - St. Louis ( Site 0053)
Hazelwood, Missouri, 63042, United States
Alliance for Multispecialty Research, LLC ( Site 0071)
Kansas City, Missouri, 64114, United States
Skyline Medical Center/CCT Research ( Site 0148)
Elkhorn, Nebraska, 68022, United States
Velocity Clinical Research at The Pioneer Heart Institute, Lincoln ( Site 0078)
Lincoln, Nebraska, 68510, United States
CHI Health Clinic Heart Institute ( Site 0180)
Lincoln, Nebraska, 68526, United States
Excel Clinical Research, LLC ( Site 0123)
Las Vegas, Nevada, 89109, United States
Clinical Research of South Nevada ( Site 0135)
Las Vegas, Nevada, 89121-4350, United States
Advanced Heart Care - Bridgewater Route 22 ( Site 0160)
Bridgewater, New Jersey, 08807, United States
Cardiovascular Associates of the Delaware Valley ( Site 0162)
Washington Township, New Jersey, 08080, United States
New Mexico Clinical Research & Osteoporosis Center ( Site 0005)
Albuquerque, New Mexico, 87106, United States
Velocity Clinical Research, Binghamton ( Site 0063)
Binghamton, New York, 13905, United States
Central New York Clinical Research ( Site 0044)
Manlius, New York, 13104, United States
North Shore Diabetes & Endocrine Associates ( Site 0165)
New Hyde Park, New York, 11042, United States
Mid Hudson Medical Research ( Site 0087)
New Windsor, New York, 12553, United States
NYU Langone Health ( Site 0099)
New York, New York, 10016, United States
Rochester Clinical Research, Inc. ( Site 0098)
Rochester, New York, 14609, United States
Laurelton Heart Specialist PC ( Site 0092)
Rosedale, New York, 11422, United States
Duke University Health System (DUHS) ( Site 0153)
Durham, North Carolina, 27710, United States
Wake Forest Baptist Health-Cardiovascular Medicine ( Site 0142)
Winston-Salem, North Carolina, 27157, United States
Lillestol Research ( Site 0025)
Fargo, North Dakota, 58104, United States
Altru Health System ( Site 0197)
Grand Forks, North Dakota, 58201, United States
Velocity Clinical Research, Springdale ( Site 0112)
Cincinnati, Ohio, 45246, United States
Cleveland Clinic Main ( Site 0121)
Cleveland, Ohio, 44195, United States
The Ohio State Wexner Medical Center ( Site 0200)
Columbus, Ohio, 43203, United States
Remington-Davis, Inc. ( Site 0183)
Columbus, Ohio, 43215, United States
Premier Cardiovascular Institute ( Site 0136)
Dayton, Ohio, 45414, United States
Genesis Healthcare System-Pharmacy Research ( Site 0163)
Zanesville, Ohio, 43701, United States
South Oklahoma Heart Research ( Site 0164)
Oklahoma City, Oklahoma, 73135, United States
Capital Area Research, LLC ( Site 0139)
Camp Hill, Pennsylvania, 17011, United States
Guthrie Medical Group, P.C. ( Site 0176)
Sayre, Pennsylvania, 18840, United States
Cardiology Consultants of Philadelphia Yardley ( Site 0072)
Yardley, Pennsylvania, 19067, United States
Velocity Clinical Research, Anderson ( Site 0022)
Anderson, South Carolina, 29621, United States
Coastal Carolina Research Center ( Site 0006)
North Charleston, South Carolina, 29405, United States
Monument Health Clinical Research, a department of Monument -Monument Health Clinical Research, a d ( Site 0009)
Rapid City, South Dakota, 57701, United States
Holston Medical Group ( Site 0106)
Bristol, Tennessee, 37620, United States
Holston Medical Group ( Site 0047)
Kingsport, Tennessee, 37660, United States
Alliance for Multispecialty Research, LLC ( Site 0008)
Knoxville, Tennessee, 37909, United States
PharmaTex Research, LLC ( Site 0182)
Amarillo, Texas, 79106, United States
Texas Diabetes and Endocrinology, P.A. ( Site 0187)
Austin, Texas, 78731, United States
Southwest Family Medicine Associates ( Site 0189)
Dallas, Texas, 75235, United States
Prolato Clinical Research Center ( Site 0108)
Houston, Texas, 77054, United States
Permian Research Foundation ( Site 0157)
Odessa, Texas, 79761, United States
LinQ Research ( Site 0101)
Pearland, Texas, 77584, United States
Northeast Clinical Research of San Antonio ( Site 0011)
San Antonio, Texas, 78233, United States
Discovery Clinical Trials ( Site 0096)
San Antonio, Texas, 78258, United States
Sugar Lakes Family Practice, PA ( Site 0094)
Sugar Land, Texas, 77479, United States
LinQ Research - Tomball ( Site 0208)
Tomball, Texas, 77375, United States
Northwest Houston Heart Center-Northwest Houston Clinical Research, PLLC ( Site 0158)
Tomball, Texas, 77375, United States
NextStage Clinical Research - Waco ( Site 0196)
Waco, Texas, 76712, United States
Synexus Clinical Research US, Inc. ( Site 0086)
Salt Lake City, Utah, 84106, United States
Highland Clinical Research ( Site 0122)
Salt Lake City, Utah, 84124, United States
Velocity Clinical Research, Salt Lake City ( Site 0019)
West Jordan, Utah, 84088, United States
Burke Internal Medicine and Research ( Site 0035)
Burke, Virginia, 22015, United States
Charlottesville Medical Research ( Site 0030)
Charlottesville, Virginia, 22911, United States
Virginia Heart ( Site 0097)
Falls Church, Virginia, 22042, United States
Carient Heart & Vascular - Manassas ( Site 0170)
Manassas, Virginia, 20109, United States
Manassas Clinical Research Center ( Site 0007)
Manassas, Virginia, 20110, United States
Health Research of Hampton Roads, Inc. ( Site 0043)
Newport News, Virginia, 23606, United States
Alliance for Multispecialty Research, LLC ( Site 0068)
Norfolk, Virginia, 23502, United States
Centricity Research Suffolk Family Medicine ( Site 0105)
Suffolk, Virginia, 23435, United States
CEDIC ( Site 0612)
CABA, Buenos Aires, C1060ABN, Argentina
CEMEDIC ( Site 0609)
CABA, Buenos Aires, C1407GTL, Argentina
Framingham Centro Médico ( Site 0625)
La Plata, Buenos Aires, B1902COS, Argentina
CIMeL ( Site 0613)
Lanus, Buenos Aires, B1824KAJ, Argentina
Instituto de Investigaciones Clínicas Mar del Plata ( Site 0605)
Mar del Plata, Buenos Aires, B7600FZO, Argentina
DIM Clínica Privada ( Site 0627)
Ramos Mejía, Buenos Aires, B1704ETD, Argentina
Go Centro Medico San Nicolás ( Site 0621)
San Nicolás de los Arroyos, Buenos Aires, 2900, Argentina
Instituto de Investigaciones Clinicas Zarate ( Site 0600)
Zárate, Buenos Aires, B2800DGH, Argentina
CIPREC-CIPREC Sede Arenales ( Site 0624)
Buenos Aires, Buenos Aires F.D., C1061AAS, Argentina
Fundación favaloro para la Docencia e Investigación Médica ( Site 0606)
Buenos Aires, Buenos Aires F.D., C1093AAS, Argentina
Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada ( Site 0604)
Buenos Aires, Buenos Aires F.D., C1425AGC, Argentina
Fundación Respirar ( Site 0610)
Buenos Aires, Buenos Aires F.D., C1426ABP, Argentina
Instituto Médico DAMIC ( Site 0603)
Córdoba, Córdoba Province, 5003DCE, Argentina
Instituto de Investigaciones Clinicas Rosario ( Site 0602)
Rosario, Santa Fe Province, S2000CVD, Argentina
Fundacion Estudios Clinicos ( Site 0619)
Rosario, Santa Fe Province, S2000DEJ, Argentina
Laboratorio de Hemostasia y Trombosis ( Site 0623)
Rosario, Santa Fe Province, S2000DTB, Argentina
Clínica de Nefrología, Urología y Enfermedades Cardiovasculares ( Site 0615)
Santa Fe, Santa Fe Province, S3000BPJ, Argentina
Sanatorio Finochietto ( Site 0626)
Buenos Aires, C1187AAN, Argentina
Centro de Investigaciones Metabólicas (CINME) ( Site 0620)
CABA, C1056ABI, Argentina
Instituto de Cardiología "Juana F. Cabral"-Cardiología ( Site 0608)
Corrientes, W3400AMZ, Argentina
Centro de Investigaciones Clinicas del Litoral ( Site 0607)
Santa Fe, 3000, Argentina
Paratus Clinical Research Canberra ( Site 2804)
Bruce, Australian Capital Territory, 2617, Australia
Paratus Clinical Research Western Sydney ( Site 2805)
Blacktown, New South Wales, 2148, Australia
Royal Prince Alfred Hospital ( Site 2808)
Camperdown, New South Wales, 2050, Australia
Paratus Clinical Research Central Coast ( Site 2806)
Kanwal, New South Wales, 2259, Australia
The Prince Charles Hospital ( Site 2810)
Brisbane, Queensland, 4032, Australia
Victorian Heart Hospital-Monash Cardiovascular Research Centre (MCRC) ( Site 2803)
Clayton, Victoria, 3168, Australia
Baker IDI Heart & Diabetes Institute ( Site 2809)
Hoppers Crossing, Victoria, 3029, Australia
Centro de Pesquisas em Diabetes e Doenças Endócrino-Metabólicas ( Site 0728)
Fortaleza, Ceará, 60430-350, Brazil
Centro de Pesquisa Clinica do Brasil ( Site 0719)
Brasília, Federal District, 71625-175, Brazil
Universidade Federal de Goias ( Site 0717)
Goiânia, Goiás, 74605-020, Brazil
Hospital Angelina Caron ( Site 0702)
Campina Grande do Sul, Paraná, 83430-000, Brazil
Hospital do Rocio ( Site 0721)
Campo Largo, Paraná, 83606-177, Brazil
Hospital Universitário ( Site 0723)
Canoas, Rio Grande do Sul, Brazil
Instituto de Cardiologia do Rio Grande do Sul ( Site 0704)
Porto Alegre, Rio Grande do Sul, 90620001, Brazil
Hospital Mae de Deus ( Site 0716)
Porto Alegre, Rio Grande do Sul, 90880-480, Brazil
Hospital Nossa Senhora da Conceição-FZ PESQUISA E SERVIÇOS EM CARDIOLOGIA CLÍNICA LTDA ( Site 0712)
Porto Alegre, Rio Grande do Sul, 91350-280, Brazil
Centro de Pesquisa Clinica do Coracao ( Site 0713)
Aracaju, Sergipe, 49055-530, Brazil
Hospital Universitário São Francisco de Assis - Bragança Paulista ( Site 0725)
Bragança Paulista, São Paulo, 12916-542, Brazil
Instituto de Pesquisa clinica de Campinas ( Site 0706)
Campinas, São Paulo, 13060-080, Brazil
Hospital e Maternidade Christóvão da Gama (HMCG) ( Site 0724)
Santo André, São Paulo, 09020-270, Brazil
Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 0707)
São José do Rio Preto, São Paulo, 15090000, Brazil
Instituto Dante Pazzanese de Cardiology-Fundação Adib Jatene ( Site 0708)
São Paulo, São Paulo, 04012-909, Brazil
CEPIC - Centro Paulista de Investigação Clínica ( Site 0710)
São Paulo, São Paulo, 04266-010, Brazil
Integral Pesquisa e Ensino ( Site 0709)
Votuporanga, São Paulo, 15500-269, Brazil
IBPClin - Instituto Brasil de Pesquisa Clínica ( Site 0715)
Rio de Janeiro, 20241-180, Brazil
OCT Research ULC ( Site 0512)
Kelowna, British Columbia, V1Y 1Z9, Canada
Cambridge Cardiac Care Centre ( Site 0508)
Cambridge, Ontario, N1R 6V6, Canada
North York Diagnostic and Cardiac Centre ( Site 0514)
North York, Ontario, M6B 3H7, Canada
Oakville Cardiovascular Research LP ( Site 0507)
Oakville, Ontario, L6K 3W7, Canada
Corcare ( Site 0511)
Toronto, Ontario, M1B 5N1, Canada
Ecogene-21 ( Site 0510)
Chicoutimi, Quebec, G7H 7K9, Canada
Institut de Cardiologie de Montreal ( Site 0506)
Montreal, Quebec, H1T 1C8, Canada
IUCPQ ( Site 0515)
Québec, Quebec, G1V 4G5, Canada
Centre intégré de santé et de services sociaux de Lanaudière - Hopital Pierre-Le Gardeur. ( Site 0509)
Terrebonne, Quebec, J6V 2H2, Canada
Diex Recherche Trois-Rivieres ( Site 0505)
Trois-Rivières, Quebec, G9A 4P3, Canada
Centro de Investigación Clinica Del Sur ( Site 0821)
Temuco, Araucania, 4781156, Chile
Centro De Estudios Cardiologicos Y De Medicina Interna ( Site 0805)
Temuco, Araucania, 4813299, Chile
Biocenter ( Site 0819)
Concepción, Biobio, 4070196, Chile
Clinical Research Chile SpA ( Site 0804)
Valdivia, Los Ríos Region, 5110683, Chile
Centro de Investigación del Maule ( Site 0816)
Talca, Maule Region, 3460000, Chile
Espacio Eme ( Site 0806)
Ñuñoa, Region M. de Santiago, 7770086, Chile
Servicios Medicos Godoy ( Site 0810)
Providencia, Region M. de Santiago, 7500710, Chile
Enroll SpA ( Site 0803)
Santiago, Region M. de Santiago, 7500587, Chile
FALP-UIDO ( Site 0815)
Santiago, Region M. de Santiago, 7500921, Chile
CECIM ( Site 0811)
Santiago, Region M. de Santiago, 8320000, Chile
Centro de Investigacion Clinicadela Universidad Catolica ( Site 0812)
Santiago, Region M. de Santiago, 8330034, Chile
Universidad de Chile - Hospital Clínico Universidad de Chile ( Site 0800)
Santiago, Region M. de Santiago, 8380420, Chile
Clínica Ensenada ( Site 0801)
Santiago, Region M. de Santiago, 8380465, Chile
Centro Respiratorio Integral - CENRESIN. ( Site 0820)
Quillota, Valparaiso, 5501775, Chile
ONCOCENTRO APYS ( Site 0808)
Viña del Mar, Valparaiso, 2520598, Chile
Second Affiliated hospital of Anhui Medical University-Cardiology ( Site 3458)
Hefei, Anhui, 230601, China
Beijing Anzhen Hospital, Capital Medical University-Cardiovascular ( Site 3400)
Beijing, Beijing Municipality, 100029, China
Beijing Tsinghua Changgung Hospital ( Site 3423)
Beijing, Beijing Municipality, 102218, China
The Second Affiliated Hospital of Chongqing Medical University ( Site 3424)
Chongqing, Chongqing Municipality, 400072, China
Chongqing University Three Gorges Hospital ( Site 3441)
Chongqing, Chongqing Municipality, 404000, China
The Eighth Affiliated Hospital of Southern Medical University ( Site 3427)
Foshan, Guangdong, 528399, China
Guangdong Provincial People's Hospital-Cardiology ( Site 3402)
Guangzhou, Guangdong, 510080, China
Zhujiang Hospital of Southern Medical University ( Site 3415)
Guangzhou, Guangdong, 510280, China
Huizhou Municipal Central Hospital ( Site 3467)
Huizhou, Guangdong, 516001, China
Jiangmen Center Hospital ( Site 3492)
Jiangmen, Guangdong, 529030, China
The University of Hong Kong-Shenzhen Hospital-Cardiovascular department ( Site 3414)
Shenzhen, Guangdong, 518053, China
The Affiliated Hospital of Guizhou Medical University ( Site 3486)
Guiyang, Guizhou, 550004, China
Hainan General Hospital ( Site 3409)
Haikou, Hainan, 570311, China
Daqing People's Hospital-Cardiology ( Site 3470)
Daqing, Heilongjiang, 163316, China
The first affiliated Hospital of Harbin Medical University-Cardiology ( Site 3406)
Harbin, Heilongjiang, 150001, China
The Fourth Hospital of Harbin Medical University-Endocrinology department ( Site 3452)
Harbin, Heilongjiang, 150001, China
The Third Affiliated Hospital of Qiqihar Medical University ( Site 3465)
Qiqihar, Heilongjiang, 161000, China
Nanyang First People's Hospital ( Site 3469)
Nanyang, Henan, 473000, China
Pu'ai Hospital of Wuhan City ( Site 3451)
Wuhan, Hubei, 430030, China
Renmin Hospital of Wuhan University ( Site 3464)
Wuhan, Hubei, 430060, China
Changsha Central Hospital-Cardiovascular ( Site 3404)
Changsha, Hunan, 410004, China
The Third Xiangya Hospital of Central South University-Cardiology ( Site 3412)
Changsha, Hunan, 410013, China
The Third Hospital of Changsha-Cardiovascular department ( Site 3434)
Changsha, Hunan, 410015, China
The First People's Hospital of Yueyang-Cardiovascular department ( Site 3448)
Yueyang, Hunan, 414000, China
Baotou Central Hospital-Cardiology ( Site 3436)
Baotou, Inner Mongolia, 014040, China
Chifeng Hospital-Department of Cardiology ( Site 3433)
Chifeng, Inner Mongolia, 024099, China
Inner Mongolia People's Hospital ( Site 3439)
Hohhot, Inner Mongolia, 010017, China
Changzhou Second People's Hospital-Cardiology ( Site 3459)
Changzhou, Jiangsu, 213000, China
The Second Affiliated Hospital of Nanjing Medical University-Cardiology ( Site 3480)
Nanjing, Jiangsu, 210011, China
The Affiliated Hospital of Xuzhou Medical College ( Site 3403)
Xuzhou, Jiangsu, 221000, China
Northern Jiangsu People's Hospital ( Site 3405)
Yangzhou, Jiangsu, 225001, China
Affiliated Hospital of Jiangsu University-Cardiology Department ( Site 3481)
Zhenjiang, Jiangsu, 212001, China
The Third Hospital of Nanchang - Fuhe-cardiology ( Site 3496)
Nanchang, Jiangxi, 330003, China
The Third Hospital of Nanchang ( Site 3454)
Nanchang, Jiangxi, 330009, China
Pingxiang People's Hospital-Cardiology ( Site 3473)
Pingxiang, Jiangxi, 337055, China
Jilin Province People's Hospital-Department of Cardiology ( Site 3442)
Changchun, Jilin, 130021, China
Siping Central People's Hospital-Cardiovascular Department ( Site 3408)
Siping, Jilin, 136000, China
The First Affiliated Hospital of Jinzhou Medical University ( Site 3476)
Jinzhou, Liaoning, 121001, China
The People's Hospital of Liaoning Province-Cardiology ( Site 3453)
Shenyang, Liaoning, 110016, China
General Hospital of Ningxia Medical University ( Site 3478)
Yinchuan, Ningxia, 750004, China
Shanxi Cardiovascular Hospital ( Site 3462)
Taiyuan, Shaanxi, 030024, China
The First Affiliated Hospital of Xi'an Jiaotong University ( Site 3420)
Xi'an, Shaanxi, 710061, China
Shaanxi provincial people's hospital ( Site 3421)
Xi'an, Shaanxi, 710068, China
Xianyang Hospital of Yan'an University ( Site 3435)
Xianyang, Shaanxi, 712000, China
Linyi People's Hospital ( Site 3468)
Linyi, Shandong, 276003, China
Zibo Municipal Hospital ( Site 3474)
Zibo, Shandong, 255400, China
Shanghai Tongji Hospital ( Site 3431)
Shanghai, Shanghai Municipality, 200065, China
Shanghai General Hospital ( Site 3479)
Shanghai, Shanghai Municipality, 200080, China
Shanghai East Hospital ( Site 3485)
Shanghai, Shanghai Municipality, 200120, China
The Third People's Hospital of Chengdu (CDTPH) ( Site 3430)
Chengdu, Sichuan, 610014, China
Chengdu Second Municipal People's Hospital ( Site 3419)
Chengdu, Sichuan, 610021, China
The Second People's Hospital of Neijiang ( Site 3482)
Neijiang, Sichuan, 641099, China
Suining Central Hospital ( Site 3487)
Suining, Sichuan, 629000, China
Tianjin People' s Hospital-Cardiology ( Site 3425)
Tianjin, Tianjin Municipality, 300121, China
Tianjin Fourth Centre Hospital-Department of Cardiology ( Site 3456)
Tianjin, Tianjin Municipality, 300140, China
The First Affiliated Hospital, Zhejiang University ( Site 3417)
Hangzhou, Zhejiang, 310003, China
Taizhou Hospital of Zhejiang Province-Cardiovascular Department ( Site 3472)
Linhai, Zhejiang, 317000, China
Lishui Central Hospital ( Site 3455)
Lishui, Zhejiang, 323030, China
Fundación Centro de Investigación Clínica CIC ( Site 0906)
Medellín, Antioquia, 050021, Colombia
Salud SURA Industriales ( Site 0917)
Medellín, Antioquia, 50021, Colombia
Rodrigo Botero S.A.S ( Site 0901)
Medellín, Antioquia, 50030, Colombia
Ciensalud Ips S A S ( Site 0903)
Barranquilla, Atlántico, 08001, Colombia
Clinica de la Costa S.A.S. ( Site 0902)
Barranquilla, Atlántico, 080020, Colombia
IPS Centro Científico Asistencial S.A.S ( Site 0900)
Barranquilla, Atlántico, 080020, Colombia
IPS Médicos Internistas de Caldas ( Site 0905)
Manizales, Caldas Department, 170004, Colombia
Instituto Cardiovascular del Cesar S.A ( Site 0919)
Valledupar, Cesar Department, 200001, Colombia
Sociedad de Cirugía de Bogotá - Hospital de San Jose ( Site 0920)
Bogota, Cundinamarca, 1100100, Colombia
Fundacion Santa Fe de Bogota ( Site 0916)
Bogotá, Cundinamarca, 110111, Colombia
Solano & Terront Servicios Medicos - UNIENDO ( Site 0915)
Bogotá, Cundinamarca, 110221, Colombia
Salud SURA Calle 100 ( Site 0918)
Bogotá, Cundinamarca, 110231, Colombia
Healthy Medical Center S.A.S ( Site 0913)
Zipaquirá, Cundinamarca, 250252, Colombia
IMAT S.A.S ( Site 0907)
Montería, Departamento de Córdoba, 230002, Colombia
Fundación Cardiovascular de Colombia ( Site 0911)
Piedecuesta, Santander Department, 681017, Colombia
Mediservis del Tolima IPS S.A.S ( Site 0914)
Ibague, Tolima Department, 730006, Colombia
Fundación Valle del Lili ( Site 0904)
Cali, Valle del Cauca Department, 760032, Colombia
Centro de Investigaciones Clinicas SAS ( Site 0912)
Cali, Valle del Cauca Department, 760036, Colombia
Herlev and Gentofte Hospital-Department of Cardiology ( Site 1210)
Copenhagen, Capital Region, 2730, Denmark
Sanos Clinic-Sanos Clinic ( Site 1204)
Herlev, Capital Region, 2730, Denmark
Aarhus Universitetshospital, Skejby ( Site 1201)
Aarhus, Central Jutland, 8200, Denmark
Regionshospitalet Gødstrup ( Site 1207)
Herning, Central Jutland, 7400, Denmark
Sanos Clinic - Nordjylland ( Site 1203)
Gandrup, North Denmark, 9362, Denmark
Sygehus Vendsyssel Hjoerring ( Site 1209)
Hjørring, North Denmark, 9800, Denmark
Roskilde Sygehus ( Site 1212)
Roskilde, Region Sjælland, 4000, Denmark
Slagelse Sygehus-Ambulatorium for Hjertesygdomme ( Site 1205)
Slagelse, Region Sjælland, 4200, Denmark
Sydvestjysk Sygehus Esbjerg ( Site 1206)
Esbjerg, Region Syddanmark, 6700, Denmark
Svendborg Hospital Odense Universitets hospital-Kardiologisk Forskningsenhed ( Site 1200)
Svendborg, Region Syddanmark, 5700, Denmark
Sanos Clinic - Syddanmark ( Site 1202)
Vejle, Region Syddanmark, 7100, Denmark
Centre Hospitalier Universitaire de Grenoble-Cardiology ( Site 1421)
Grenoble, Auvergne-Rhône-Alpes, 38700, France
CHRU Troussau-CARDIOLOGY ( Site 1402)
Chambray-lès-Tours, Centre-Val de Loire, 37170, France
CENTRE HOSPITALIER REGIONAL D'ORLEANS-Service de Cardiologie ( Site 1416)
Orléans, Centre-Val de Loire, 45067, France
Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François Mitterrand ( Site 1409)
Dijon, Cote-d Or, 21079, France
Centre Hospitalier Louis Pasteur ( Site 1405)
Le Coudray, Eure-et-Loir, 28630, France
Centre Hospitalier Universitaire de Nîmes - Hôpital Universitaire Carémeau ( Site 1401)
Nîmes, Gard, 30029, France
Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren ( Site 1413)
Limoges, Haute-Vienne, 87042, France
Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou ( Site 1404)
Rennes, Ille-et-Vilaine, 35000, France
Centre Hospitalier Universitaire de Reims - Hôpital Robert Debré ( Site 1418)
Reims, Marne, 51092, France
Polyclinique Vauban ( Site 1406)
Valenciennes, Nord, 59300, France
Pitie Salpetriere University Hospital ( Site 1414)
Paris, Orne, 75013, France
Centre Hospitalier Universitaire de Saint Étienne - Hôpital Nord ( Site 1400)
Saint Priest En Jarez, Pays de la Loire Region, 42270, France
Centre Hospitalier de Pau ( Site 1408)
Pau, Pyrenees-Atlantiques, 64046, France
Clinique du Pont de Chaume ( Site 1407)
Montauban, Tarn-et-Garonne, 82017, France
Centre Hospitalier Universitaire de Poitiers ( Site 1417)
Poitiers, Vienne, 86021, France
Klinikum am Plattenwald ( Site 1590)
Bad Friedrichshall, Baden-Wurttemberg, 74177, Germany
Siteworks GmbH - Heidelberg ( Site 1546)
Heidelberg, Baden-Wurttemberg, 69115, Germany
ze:ro ARZTPRAXEN-Ze:ro Praxen ( Site 1583)
Mannheim, Baden-Wurttemberg, 68165, Germany
Kardiologische Gemeinschaftspraxis ( Site 1564)
Nuremberg, Bavaria, 90402, Germany
Gemeinschaftspraxis Dr. med. Josef und Wilma Großkopf ( Site 1547)
Wallerfing, Bavaria, 94574, Germany
Kerckhoff-Klinik ( Site 1599)
Bad Nauheim, Hesse, 61231, Germany
Synexus Clinical Research GmbH Synexus Frankfurt Clinical Research Centre ( Site 1592)
Frankfurt am Main, Hesse, 60313, Germany
ClinPhenomics CVC GmbH ( Site 1593)
Frankfurt am Main, Hesse, 60596, Germany
Siteworks GmbH ( Site 1552)
Hanover, Lower Saxony, 30449, Germany
Studienzentrum Brinkum - Torsten Drescher & Dr. Lars Pohlmeier ( Site 1557)
Stuhr, Lower Saxony, 28816, Germany
Klinikum Bielefeld Mitte ( Site 1561)
Bielefeld, North Rhine-Westphalia, 33604, Germany
Zentrum fur klinische Forschung - Köln ( Site 1573)
Cologne, North Rhine-Westphalia, 51069, Germany
St.-Johannes-Hospital Dortmund-Clinic of Internal medicine I ( Site 1567)
Dortmund, North Rhine-Westphalia, 44137, Germany
Die Bocholder Hausärzte ( Site 1587)
Essen, North Rhine-Westphalia, 45355, Germany
Klinisches Forschungszentrum Dr. Hagemann am Hausarztzentrum am Germaniaplatz ( Site 1554)
Essen, North Rhine-Westphalia, 45355, Germany
Unterfrintroper Hausarztzentrum Klinische Forschung ( Site 1550)
Essen, North Rhine-Westphalia, 45359, Germany
Forschungszentrum Ruhr ( Site 1586)
Witten, North Rhine-Westphalia, 58455, Germany
Kardiopraxis Schirmer Kaiserslautern ( Site 1576)
Kaiserslautern, Rhineland-Palatinate, 67655, Germany
Siteworks GmbH - Völklingen ( Site 1553)
Völklingen, Saarland, 66333, Germany
Zentrum fuer klinische Pruefungen in der Facharztzentrum Dresden Neustadt GbR ( Site 1597)
Dresden, Saxony, 01099, Germany
Universitaetsklinikum Carl Gustav Carus Dresden-Universitätsstudienzentrum für Stoffwechselerkranku ( Site 1549)
Dresden, Saxony, 01307, Germany
Synexus Leipzig Clinical Research Centre ( Site 1591)
Leipzig, Saxony, 04103, Germany
Hausarzt- und Diabetologische Schwerpunktpraxis Hohenmölsen - Weiβenfels ( Site 1574)
Hohenmölsen, Saxony-Anhalt, 06679, Germany
Praxis Rankestrasse ( Site 1548)
Berlin, 10789, Germany
Charite Universitätsmedizin Berlin Campus Benjamin Franklin ( Site 1568)
Berlin, 12203, Germany
DRK Kliniken Berlin - Köpenick ( Site 1580)
Berlin, 12559, Germany
Synexus Berlin Clinical Research Centre ( Site 1585)
Berlin, 12627, Germany
Jüdisches Krankenhaus Berlin ( Site 1595)
Berlin, 13347, Germany
Universitaetsklinikum Hamburg-Eppendorf ( Site 1556)
Hamburg, 20246, Germany
Cardiologicum Hamburg ( Site 1596)
Hamburg, 22041, Germany
Queen Mary Hospital-Medicine - Cardiology ( Site 3303)
Hksar, Hong Kong
Queen Mary Hospital-Medical ( Site 3300)
Pok Fu Lam, Hong Kong
Prince of Wales Hospital ( Site 3301)
Shatin, Hong Kong
Prince of Wales Hospital ( Site 3304)
Shatin, Hong Kong
Our Lady of Maryknoll Hospital-Department of Medicine and Geriatrics ( Site 3305)
Wong Tai Sin, 999077, Hong Kong
Private Practice - Dr. Lakatos Ferenc ( Site 1618)
Békéscsaba, Bekes County, 5600, Hungary
Lausmed Egészségügyi Szolgáltató ( Site 1621)
Baja, Bács-Kiskun county, 6500, Hungary
Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ-Belgyógyászati Klinika ( Site 1617)
Szeged, Csongrád megye, 6725, Hungary
Fejér Megyei Szent György Egyetemi Oktató Kórház-2nd Department of Internal Medicine ( Site 1611)
Székesfehérvár, Fejér, 8000, Hungary
Belinus Orvosi és Számitástechnikai Bt ( Site 1608)
Debrecen, Hajdú-Bihar, Hungary
CoroMed ( Site 1612)
Pécs, Pecs, 7623, Hungary
Óbudai Egészségügyi Centrum - Kaposvár Site ( Site 1625)
Kaposvár, Somogy County, 7400, Hungary
Borbánya Praxis-Private practice ( Site 1606)
Nyíregyháza, Borbánya, Szabolcs-Szatmár-Bereg, 4405, Hungary
DRC Gyógyszervizsgáló Központ ( Site 1609)
Balatonfüred, Veszprém megye, 8230, Hungary
Zuglói Egészségügyi Szolgálat ( Site 1613)
Budapest, Zala County, 1148, Hungary
Óbudai Egészségügyi Centrum ( Site 1622)
Budapest, 1036, Hungary
Gottsegen György Országos Kardiovaszkuláris Intézet ( Site 1605)
Budapest, 1096, Hungary
Semmelweis Egyetem-Városmajori Szív- és Érgyógyászati Klinika ( Site 1601)
Budapest, 1122, Hungary
Medoc Egészégközpont - Lehel ( Site 1615)
Budapest, 1134, Hungary
Cardiogeneral Egészségügyi Kft. ( Site 1610)
Budapest, 1141, Hungary
Debreceni Egyetem Klinikai Kozpont-Belgyógyászati Klinika (Anyagcsere Tanszék) ( Site 1607)
Debrecen, 4032, Hungary
Óbudai Egészségügyi Centrum - Zalaegerszeg ( Site 1624)
Zalaegerszeg, 8900, Hungary
Barzilai Medical Center ( Site 1713)
Ashkelon, 7830604, Israel
Soroka Medical Center ( Site 1715)
Beersheba, 8410101, Israel
Hillel Yaffe Medical Center ( Site 1705)
Hadera, 3810101, Israel
Linn Medical Center ( Site 1711)
Haifa, 3100000, Israel
Rambam Health Care Campus ( Site 1702)
Haifa, 3109601, Israel
Rambam Health Care Campus ( Site 1718)
Haifa, 3109601, Israel
Institute of Diabetes, Technology and Research - Clalit Health ( Site 1701)
Herzliya, 4630945, Israel
Clalit health Services - Holon Medical Center ( Site 1721)
Holon, 5840608, Israel
Shaare Zedek Medical Center ( Site 1710)
Jerusalem, 9103102, Israel
Hadassah Medical Center ( Site 1706)
Jerusalem, 9112001, Israel
Hadassah Medical Center ( Site 1709)
Jerusalem, 9112001, Israel
Clalit Health Services - Majd Al-Krum Clinic ( Site 1722)
Majd el Kurūm, 2019000, Israel
Galilee Medical Center ( Site 1723)
Nahariya, 2210001, Israel
Rabin Medical Center ( Site 1720)
Petah Tikva, 4941 492, Israel
Rabin Medical Center ( Site 1703)
Petah Tikva, 4941492, Israel
Sheba Medical Center ( Site 1708)
Ramat Gan, 5265601, Israel
Kaplan Medical Center ( Site 1724)
Rehovot, 7661041, Israel
Clalit Health Services - Sakhnin Community Clinic-Research Unit ( Site 1700)
Sakhnin, 3081000, Israel
Azienda Ospedaliero Universitaria di Ferrara ( Site 1816)
Cona, Ferrara, 44124, Italy
Fondazione Policlinico Universitario Campus Bio-Medico ( Site 1818)
Rome, Lazio, 00128, Italy
Fondazione Policlinico Tor Vergata ( Site 1809)
Rome, Lazio, 00133, Italy
AOU Policlinico Umberto I-Dipartimento di Scienze Cliniche, Internistiche, Anestesiologiche e Cardi ( Site 1808)
Rome, Lazio, 00161, Italy
Policlinico Gemellli - UOC di cardiologia ( Site 1821)
Rome, Lazio, 168, Italy
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII-Cardiologia 1 ( Site 1817)
Bergamo, Lombardy, 20127, Italy
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia ( Site 1820)
Brescia, Lombardy, 25123, Italy
Centro Cardiologico Monzino ( Site 1804)
Milan, Milano, 20138, Italy
ASST Grande Ospedale Metropolitano Niguarda-Unità Ricerche Cliniche della Cardiologia 4 ( Site 1811)
Milan, Milano, 20162, Italy
Policlinico di Monza centro diabetologia e malattie metaboliche ( Site 1806)
Monza, Monza E Brianza, 20052, Italy
Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino ( Site 1801)
Turin, Piedmont, 10126, Italy
A.O.U. Policlinico Paolo Giaccone ( Site 1815)
Palermo, Sicily, 90129, Italy
ASST DI LECCO ( Site 1814)
Lecco, 23900, Italy
University of Naples Federico II ( Site 1805)
Naples, 80131, Italy
Azienda Ospedaliero Universitaria di Parma ( Site 1813)
Parma, 43126, Italy
Fondazione IRCCS Policlinico San Matteo-Cardiology ( Site 1802)
Pavia, 27100, Italy
Ospedale Mauriziano ( Site 1812)
Torino, 10128, Italy
Nagoya Kyoritsu Hospital ( Site 3531)
Nagoya, Aichi-ken, 454-0933, Japan
Chubu Rosai Hospital ( Site 3507)
Nagoya, Aichi-ken, 455-8530, Japan
Toyota Kosei Hospital ( Site 3519)
Toyota, Aichi-ken, 470-0396, Japan
Toyota Memorial Hospital ( Site 3539)
Toyota, Aichi-ken, 471-8513, Japan
Seikeikai Medical Corporation New Tokyo Heart Clinic ( Site 3537)
Matsudo, Chiba, 271-0077, Japan
Nakamura Cardiovascular Clinic ( Site 3529)
Itoshima, Fukuoka, 819-1104, Japan
Fukuoka Tokushukai Hospital ( Site 3511)
Kasuga, Fukuoka, 816-0864, Japan
Kokura Memorial Hospital ( Site 3521)
Kitakyushu, Fukuoka, 802-8555, Japan
Go Neurosurgical Clinic ( Site 3534)
Nakagawa, Fukuoka, 811-1244, Japan
Matsuda Cardiovascular Clinic ( Site 3526)
Sapporo, Hokkaido, 003-0026, Japan
Hyogo Prefectural Harima-Himeji General Medical Center ( Site 3514)
Himeji, Hyōgo, 670-8560, Japan
Tsukuba Medical Center Hospital ( Site 3540)
Tsukuba, Ibaraki, 305-8558, Japan
TAKAMATSU Red Cross Hospital ( Site 3506)
Takamatsu, Kagawa-ken, 760-0017, Japan
Kagawa Prefectural Central Hospital ( Site 3538)
Takamatsu, Kagawa-ken, 760-8557, Japan
Fujisawa City Hospital ( Site 3522)
Fujisawa, Kanagawa, 251-8550, Japan
Tokai University Hospital ( Site 3500)
Isehara, Kanagawa, 259-1193, Japan
Shonan Kamakura General Hospital ( Site 3516)
Kamakura, Kanagawa, 247-8533, Japan
Kyoto Okamoto Memorial Hospital ( Site 3524)
Kuse-gun Kumiyama-cho, Kyoto, 613-0034, Japan
Uji-Tokushukai Medical Center ( Site 3509)
Uji, Kyoto, 611-0041, Japan
National Hospital Organization Nagasaki Medical Center ( Site 3505)
Ōmura, Nagasaki, 856-8562, Japan
Saga-Ken Medical Centre Koseikan ( Site 3543)
Saga, Saga-ken, 840-8571, Japan
Hanyu General Hospital ( Site 3504)
Hanyū, Saitama, 348-8505, Japan
Tokyonishi Tokushukai Hospital ( Site 3530)
Akishima, Tokyo, 196-0003, Japan
Minamino Cardiovascular Hospital ( Site 3546)
Hachiōji, Tokyo, 192-0918, Japan
Affiliated Central Clinic of Higashiyamato Hospital ( Site 3533)
Higashiyamato, Tokyo, 207-0014, Japan
Saiseikai Fukuoka General Hospital ( Site 3536)
Fukuoka, 810-0001, Japan
Fukuoka University Hospital ( Site 3502)
Fukuoka, 814-0180, Japan
Japanese Red Cross Fukuoka Hospital ( Site 3528)
Fukuoka, 815-8555, Japan
Kumamoto University Hospital ( Site 3501)
Kumamoto, 860-8556, Japan
Saiseikai Kumamoto Hospital ( Site 3515)
Kumamoto, 861-4193, Japan
Kyoto City Hospital ( Site 3542)
Kyoto, 604-8845, Japan
Nagasaki Harbor Medical Center ( Site 3527)
Nagasaki, 850-8555, Japan
Okayama City General Medical Center Okayama City Hospital ( Site 3508)
Okayama, 700-8557, Japan
National Hospital Organization Okayama Medical Center ( Site 3512)
Okayama, 7011192, Japan
National Hospital Organization Osaka National Hospital ( Site 3503)
Osaka, 540-0006, Japan
Sanai Hospital - Saitama ( Site 3532)
Saitama, 332-0012, Japan
Saitama City Hospital ( Site 3535)
Saitama, 336-8522, Japan
Machida Municipal Hospital ( Site 3545)
Tokyo, 194-0023, Japan
Centro de Investigacion Cardiovascular y Metabólica ( Site 1027)
Tijuana, Estado de Baja California, 22500, Mexico
Morales Vargas Centro de Investigacion ( Site 1029)
León, Guanajuato, 37000, Mexico
Grupo Ollin Care ( Site 1023)
Pachuca, Hidalgo, 42000, Mexico
Instituto Jalisciense de Investigacion en Diabetes y Obesidad-Endocrinology ( Site 1007)
Guadalajara, Jalisco, 04460, Mexico
Unidad de Investigaci�n Cl�nica Cardiometabolica de Occident-Unidad de Investigación Clínica Cardio ( Site 1015)
Guadalajara, Jalisco, 44150, Mexico
Cardiocent de Guadalajara S.C.-cardiocent de guadalajara SC ( Site 1001)
Guadalajara, Jalisco, 44160, Mexico
Centro de Investigación Médico Biológica y Terapia Avanzada ( Site 1021)
Guadalajara, Jalisco, 44650, Mexico
Centro de Investigacion Medica de Occidente, S.C.-Departamento de Centro de Investigacion Medica d ( Site 1022)
Zapopan, Jalisco, 44260, Mexico
Bio Investigación AMARC, S.C. ( Site 1013)
Gustavo Adolfo Madero, Mexico City, 07800, Mexico
HOSPITAL GENERAL DE MEXICO DR. EDUARDO LICEAGA-Farmacologia Clinica ( Site 1033)
Mexico City, Mexico City, 06720, Mexico
Centro de Imagen y Tecnología en Intervención Cardiovascular-Research ( Site 1041)
Mexico City, Mexico City, 10400, Mexico
Clínica Integral del Paciente Diabético y Obeso ( Site 1016)
Mexico City, Mexico City, 11850, Mexico
Medica Sur-Clinica de Enfermedades Digestivas y Obesidad ( Site 1024)
Mexico City, Mexico City, 14050, Mexico
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran ( Site 1012)
Mexico City, Mexico City, 14080, Mexico
CHRISTUS Centro de Excelencia en Investigación (Norte) ( Site 1032)
General Escobedo, Nuevo León, 66055, Mexico
Hospital Universitario "Dr. Jose Eleuterio Gonzalez"-Endocrinologia ( Site 1025)
Monterrey, Nuevo León, 64460, Mexico
Unidad biomedica avanzada monterrey-Clinical Trials ( Site 1000)
Monterrey, Nuevo León, 64460, Mexico
Centro de investigación y control metabólico ( Site 1003)
Monterrey, Nuevo León, 66465, Mexico
Centro de Estudios de Investigacion Metabolicos y Cardiovasculares, S.C. ( Site 1006)
Ciudad Madero, Tamaulipas, 89440, Mexico
Centro Multidisciplinario para el Desarrollo Especializado de la Investigacion Clinica en Yucatan ( Site 1017)
Mérida, Yucatán, 97130, Mexico
Centro de Atención e Investigación Clínica ( Site 1010)
Aguascalientes, 20129, Mexico
Centro de Investigación Cardiometabólica de Aguascalientes ( Site 1034)
Aguascalientes, 20230, Mexico
Fundación Cardiovascular de Aguascalientes A.C. ( Site 1020)
Aguascalientes, 20230, Mexico
ICARO Investigaciones en Medicina ( Site 1005)
Chihuahua City, 31000, Mexico
Centro de Investigación y Gastroenterología ( Site 1002)
Cuauhtémoc, 06700, Mexico
Instituto Nacional de Cardiologia Ignacio Chavez-Endocrinology ( Site 1018)
México, 14080, Mexico
Oaxaca Site Management Organization S.C. ( Site 1004)
Oaxaca City, 68000, Mexico
Centro de Investigacion Clinica de Oaxaca ( Site 1011)
Oaxaca City, 68020, Mexico
Instituto Veracruzano en Investigación Clínica S.C. ( Site 1035)
Veracruz, 91851, Mexico
Arké SMO S.A de C.V ( Site 1026)
Veracruz, 91900, Mexico
Treant, locatie Scheper Ziekenhuis ( Site 1918)
Emmen, Drenthe, 7824 AA, Netherlands
Treant, locatie Ziekenhuis Bethesda-Bethesda Diabetes Research Center ( Site 1930)
Hoogeveen, Drenthe, 7909 AA, Netherlands
Gelre Ziekenhuis ( Site 1907)
Apeldoorn, Gelderland, 7334 DZ, Netherlands
Slingeland Ziekenhuis ( Site 1941)
Doetinchem, Gelderland, 7009 BL, Netherlands
Ziekenhuis Gelderse Vallei ( Site 1939)
Ede, Gelderland, 6716 RP, Netherlands
Ziekenhuis St. Jansdal ( Site 1917)
Harderwijk, Gelderland, 3844 DG, Netherlands
Radboudumc-Cardiology ( Site 1925)
Nijmegen, Gelderland, 6525 GA, Netherlands
Ziekenhuis Rivierenland-Remati ( Site 1916)
Tiel, Gelderland, 4002 WP, Netherlands
Gelre Ziekenhuizen ( Site 1908)
Zutphen, Gelderland, 7207 AE, Netherlands
VieCuri Medisch Centrum, locatie Venlo-Cardiology ( Site 1923)
Venlo, Limburg, 5912 BL, Netherlands
Amphia Ziekenhuis, locatie Breda Molengracht-Research cardiology ( Site 1903)
Breda, North Brabant, 4818 CK, Netherlands
Catharina Ziekenhuis ( Site 1934)
Eindhoven, North Brabant, 5623 EJ, Netherlands
Elkerliek Ziekenhuis ( Site 1938)
Helmond, North Brabant, 5707 HA, Netherlands
Bravis Ziekenhuis, locatie Roosendaal ( Site 1905)
Roosendaal, North Brabant, 4708 AE, Netherlands
Noordwest Ziekenhuisgroep-Research Cardiology ( Site 1914)
Alkmaar, North Holland, 1815 JD, Netherlands
Ziekenhuis Amstelland-Cardiologie ( Site 1920)
Amstelveen, North Holland, 1186AM, Netherlands
Onze Lieve Vrouwe Gasthuis ( Site 1922)
Amsterdam, North Holland, 1051 AC, Netherlands
Amsterdam UMC, locatie AMC-Vascular Medicine Clin Trial Unit ( Site 1926)
Amsterdam, North Holland, 1105 AZ, Netherlands
Tergooiziekenhuizen, locatie Hilversum ( Site 1929)
Hilversum, North Holland, 1213 XZ, Netherlands
Dijklander Ziekenhuis ( Site 1936)
Hoorn, North Holland, 1624 NP, Netherlands
Zaans Medisch Centrum ( Site 1942)
Zaandam, North Holland, 1502 DV, Netherlands
Ziekenhuisgroep Twente, locatie Almelo-Cardioresearch ZGT ( Site 1919)
Almelo, Overijssel, 7609 PP, Netherlands
Medische Centrum Leeuwarden ( Site 1935)
Leeuwarden, Provincie Friesland, 8934 AD, Netherlands
Antonius Ziekenhuis, locatie D&A Research and Genetics ( Site 1928)
Sneek, Provincie Friesland, 8601 ZR, Netherlands
Reinier de Graaf Ziekenhuis, locatie Delft-Research Department Cardiology ( Site 1915)
Delft, South Holland, 2625 AD, Netherlands
Albert Schweitzer Ziekenhuis, locatie Dordwijk ( Site 1901)
Dordrecht, South Holland, 3318 AT, Netherlands
Groene Hart Ziekenhuis-Research Cardiologie ( Site 1932)
Gouda, South Holland, 2803 HH, Netherlands
Leids Universitair Medisch Centrum ( Site 1924)
Leiden, South Holland, 2333 ZA, Netherlands
Alrijne Ziekenhuis, locatie Leiderdorp ( Site 1902)
Leiderdorp, South Holland, 2353 GA, Netherlands
Erasmus Medisch Centrum, Centrumlocatie ( Site 1943)
Rotterdam, South Holland, 3015 GD, Netherlands
Ikazia Ziekenhuis ( Site 1911)
Rotterdam, South Holland, 3083 AN, Netherlands
Haga Ziekenhuis locatie Leyweg ( Site 1909)
The Hague, South Holland, 2545 AA, Netherlands
Meander Medisch Centrum ( Site 1933)
Amersfoort, Utrecht, 3813 TZ, Netherlands
Admiraal de Ruyter Ziekenhuis, locatie Goes ( Site 1900)
Goes, Zeeland, 4462 RA, Netherlands
Martini Ziekenhuis ( Site 1940)
Groningen, 9728 NT, Netherlands
Pacific Clinical Research Network - Rotorua ( Site 2902)
Rotorua, Bay of Plenty, 3010, New Zealand
Momentum Clinical Research - Tauranga ( Site 2907)
Tauranga, Bay of Plenty, 3110, New Zealand
New Zealand Clinical Research (Christchurch) ( Site 2901)
Christchurch, Canterbury, 8011, New Zealand
Pacific Clinical Research Network - Forte ( Site 2903)
Christchurch, Canterbury, 8013, New Zealand
Momentum Clinical Research Hawke's Bay ( Site 2913)
Hastings, Hawkes Bay, 4122, New Zealand
Momentum Clinical Research - Palmerston North ( Site 2909)
Palmerston North, Manawatu-Wanganui, 4414, New Zealand
Momentum Clinical Research Dunedin ( Site 2910)
Dunedin, Otago, 9016, New Zealand
Lakeland Clinical Trials Waikato ( Site 2906)
Nawton, Waikato Region, 3200, New Zealand
Lakeland Clinical Trials Wellington ( Site 2904)
Ebdentown, Wellington Region, 5018, New Zealand
Momentum Clinical Research Lower Hutt ( Site 2914)
Lower Hutt, Wellington Region, 5010, New Zealand
Waitemata District Health Board ( Site 2915)
Auckland, 0622, New Zealand
New Zealand Clinical Research (Auckland) ( Site 2900)
Auckland, 0624, New Zealand
Waitemata Clinical Research Ltd ( Site 2916)
Auckland, 0626, New Zealand
Auckland City Hospital ( Site 2911)
Auckland, 1023, New Zealand
Pacific Clinical Research Network - Tasman ( Site 2905)
Nelson, 7011, New Zealand
Momentum Clinical Research Kapiti ( Site 2912)
Wellington, 5036, New Zealand
Akershus Universitetssykehus-Hjertemedisinsk Avdeling ( Site 2028)
Lorenskog, Akershus, 1478, Norway
Haukeland Universitetssjukehus ( Site 2023)
Bergen, Hordaland, 5021, Norway
Ålesund sjukehus ( Site 2029)
Ålesund, Møre og Romsdal, 6017, Norway
Nordlandssykehuset ( Site 2021)
Bodø, Nordland, 8005, Norway
Sykehuset Innlandet HF Lillehammer-Medisinsk avdeling ( Site 2030)
Lillehammer, Oppland, 2629, Norway
Oslo Universitetssykehus Aker-Lipidklinikken ( Site 2020)
Oslo, 0316, Norway
Colosseumsklinikken AS ( Site 2024)
Oslo, 0369, Norway
Oslo Universitetssykehus Rikshospitalet-Kardiologisk avdeling ( Site 2025)
Oslo, 0372, Norway
Oslo Universitetssykehus Ullevål ( Site 2031)
Oslo, 0450, Norway
Hogar Clínica San Juan de Dios ( Site 1115)
Arequipa, Ariqipa, 05154, Peru
Centro de investigacion Clínica Trujillo-Medical specialties ( Site 1104)
Trujillo, La Libertad, 13001, Peru
Clínica San Antonio ( Site 1118)
Trujillo, La Libertad, 13008, Peru
Policlínico Especializado en Neurología ( Site 1112)
La Perla-Callao, Lima, 07011, Peru
ASOCIACION CIVIL POR LA SALUD ( Site 1107)
Miraflores, Muni Metro de Lima, 15048, Peru
Hospital Alberto Sabogal Sologuren ( Site 1109)
Bellavista, Qallaw, 07011, Peru
Unidad de Investigacon de la Clinica Internacional ( Site 1116)
Lima, 15001, Peru
Clínica Internacional - Sede San Borja ( Site 1111)
Lima, 15036, Peru
Clínica Vesalio-Cardiology ( Site 1101)
Lima, 15036, Peru
Clínica Javier Prado ( Site 1100)
Lima, 15046, Peru
Hospital Militar Geriátrico ( Site 1114)
Lima, 15064, Peru
CLINICA DELGADO ( Site 1117)
Lima, 15074, Peru
Clínica El Golf-Cardiologia ( Site 1103)
Lima, 15076, Peru
Clínica Providencia ( Site 1102)
Lima, 15088, Peru
Hospital Cayetano Heredia-Servicio de cardiologia ( Site 1113)
Lima, Lima 31, Peru
Centro de Investigación Clínica Belén ( Site 1108)
Piura, 20000, Peru
Instituto Médico Soy Diabetico ( Site 1106)
Piura, 20009, Peru
Solumed Centrum Medyczne ( Site 2123)
Poznan, Greater Poland Voivodeship, 60-529, Poland
Clinical Research Center Spółka z ograniczoną odpowiedzialnością MEDIC-R Sp.k ( Site 2150)
Poznan, Greater Poland Voivodeship, 61-731, Poland
NZOZ Centrum Medyczne KERmed ( Site 2121)
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-231, Poland
Centrum Medyczne Pratia Bydgoszcz-Centrum Medyczne Pratia Bydgoszcz ( Site 2125)
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-796, Poland
MICS Centrum Medyczne Torun ( Site 2159)
Torun, Kuyavian-Pomeranian Voivodeship, 87-100, Poland
Polsko-Amerykańskie Kliniki Serca PAKS Małopolskie Centrum Sercowo-Naczyniowe ( Site 2141)
Chrzanów, Lesser Poland Voivodeship, 32-500, Poland
Maopolskie Centrum Kliniczne ( Site 2113)
Krakow, Lesser Poland Voivodeship, 30-149, Poland
Centrum Szybkiej Diagnostyki Kardiologicznej "Kardiomed" M. Żabówka E. Żabówka ( Site 2119)
Tarnów, Lesser Poland Voivodeship, 33-100, Poland
Private Practice - Dr. Robert Witek-Ośrodek Badań Klinicznych "METABOLICA" Lek. Robert Witek ( Site 2162)
Tarnów, Lesser Poland Voivodeship, 33-100, Poland
Beata Miklaszewicz & Dariusz Dabrowski CARDIAMED s.j. ( Site 2118)
Legnica, Lower Silesian Voivodeship, 59-220, Poland
NZOZ Twoja Przychodnia ( Site 2105)
Lublin, Lublin Voivodeship, 20-857, Poland
AMEDS CLINICAL RESEARCH ( Site 2166)
Grodzisk Mazowiecki, Masovian Voivodeship, 05-825, Poland
SPZOZ im. Jana Pawła II w Grodzisku Mazowieckim ( Site 2155)
Grodzisk Mazowiecki, Masovian Voivodeship, 05-825, Poland
Szpital Grochowski im. dr med. Rafała Masztaka SPZOZ ( Site 2139)
Warsaw, Masovian Voivodeship, 04-073, Poland
Narodowy Inst. Kardiologii Stefana kardynala Wyszynskiego-Inst. Badawczy.Centr.Wsparcia Badan Klinic ( Site 2132)
Warsaw, Masovian Voivodeship, 04-628, Poland
Centrum Medyczne Medyk ( Site 2101)
Rzeszów, Podkarpackie Voivodeship, 35-055, Poland
Trial Medica ( Site 2122)
Bialystok, Podlaskie Voivodeship, 15-481, Poland
Uniwersyteckie Centrum Kliniczne ( Site 2148)
Gdansk, Pomeranian Voivodeship, 80-214, Poland
Indywidualna Specjalistyczna Praktyka Lekarska w Dziedzinie Kardiologii Lek. med. Krzysztof Cymerman ( Site 2112)
Gdynia, Pomeranian Voivodeship, 81-157, Poland
Gabinet Kardiologiczno Internistyczny ( Site 2111)
Gdynia, Pomeranian Voivodeship, 81-472, Poland
NZOZ Sopockie Centrum Badan Kardiologicznych Pro Cordis Pawel Miekus ( Site 2130)
Sopot, Pomeranian Voivodeship, 81-717, Poland
Polsko-Amerykańskie Kliniki Serca II Oddział Kardiologiczny ( Site 2140)
Bielsko-Biala, Silesian Voivodeship, 43-316, Poland
Polsko-Amerykańskie Kliniki Serca ( Site 2145)
Dąbrowa Górnicza, Silesian Voivodeship, 41-300, Poland
Centrum Medyczne Pratia Katowice ( Site 2108)
Katowice, Silesian Voivodeship, 40-081, Poland
Clinical Medical Research ( Site 2102)
Katowice, Silesian Voivodeship, 40-156, Poland
Polsko-Amerykańskie Kliniki Serca ( Site 2142)
Tychy, Silesian Voivodeship, 43-100, Poland
Indywidualna Specjalistyczna Praktyka Lekarska dr n.med. Andrzej Tomasik ( Site 2146)
Zabrze, Silesian Voivodeship, 41-800, Poland
Poradnia Kardiologiczna KOS-Zawal ( Site 2104)
Elblag, Warmian-Masurian Voivodeship, 82-300, Poland
SOMED CR ( Site 2160)
Lodz, Łódź Voivodeship, 90-368, Poland
Instytut Centrum Zdrowia Matki Polki ( Site 2165)
Lodz, Łódź Voivodeship, 93-338, Poland
Velocity Skierniewice Sp. z o. o. ( Site 2114)
Skierniewice, Łódź Voivodeship, 96-100, Poland
Polsko Amerykanskie Kliniki Serca - Zgierskie ( Site 2144)
Zgierz, Łódź Voivodeship, 95-100, Poland
Clinical Research Investigator Group ( Site 3701)
Bayamón, 00960, Puerto Rico
Investigadores del Este LLC ( Site 3700)
Humacao, 00791, Puerto Rico
Ponce Medical School Foundation Inc. ( Site 3702)
Ponce, 00716, Puerto Rico
Latin Clinical Trial Center ( Site 3704)
San Juan, 00909, Puerto Rico
Phoenix Pharma ( Site 2204)
Port Elizabeth, Eastern Cape, 6001, South Africa
IATROS INTERNATIONAL ( Site 2206)
Bloemfontein, Free State, 9301, South Africa
Lenasia Clinical Trial Centre - Johannesburg ( Site 2266)
Johannesburg, Gauteng, 1827, South Africa
Bara Cardiology Research ( Site 2258)
Johannesburg, Gauteng, 2013, South Africa
Helen Joseph Hospital-Clinical HIV Research Unit ( Site 2230)
Johannesburg, Gauteng, 2092, South Africa
Futurex Clinical. Dr Soraya Cassimjee INC ( Site 2269)
Johannesburg, Gauteng, 2192, South Africa
Netcare Sunninghill Hospital ( Site 2257)
Johannesburg, Gauteng, 2196, South Africa
Midrand Medical Centre ( Site 2202)
Midrand, Gauteng, 1685, South Africa
Zinakekele Medicall Centre ( Site 2225)
Moloto, Gauteng, 1029, South Africa
Clinical Trial Systems ( Site 2210)
Pretoria, Gauteng, 0186, South Africa
Sefako Makgatho Health Sciences University ( Site 2268)
Pretoria, Gauteng, 0204, South Africa
Jongaie Research ( Site 2211)
Pretoria West, Gauteng, 0183, South Africa
Wits Clinical Research ( Site 2220)
Soweto, Gauteng, 2013, South Africa
Enhancing Care Foundation-ECF research pharmacy ( Site 2213)
Durban, KwaZulu-Natal, 4052, South Africa
Private Practice - Dr. Neyaseelan Gounden ( Site 2207)
Durban, KwaZulu-Natal, 4093, South Africa
Tiervlei Trial Centre-Clinical ( Site 2205)
Bellville, Cape Town, Western Cape, 7530, South Africa
Helderberg Research Institute ( Site 2231)
Cape Town, Western Cape, 7130, South Africa
TREAD Research ( Site 2212)
Cape Town, Western Cape, 7500, South Africa
Excellentis Clinical Trial Consultants ( Site 2221)
George, Western Cape, 6529, South Africa
TASK Eden ( Site 2227)
George, Western Cape, 6529, South Africa
Be Part Yoluntu Centre ( Site 2209)
Paarl, Western Cape, 7626, South Africa
Paarl Research Centre ( Site 2214)
Paarl, Western Cape, 7646, South Africa
Tsitsikamma Clinical Research Initiative (TCRI) ( Site 2226)
Plettenberg Bay, Western Cape, 6600, South Africa
Clinical Projects Research ( Site 2265)
Worcester, Western Cape, 6850, South Africa
Seoul National University Bundang Hospital ( Site 3005)
Seongnam, Kyonggi-do, 13620, South Korea
Ajou University Hospital ( Site 3006)
Suwon, Kyonggi-do, 16499, South Korea
Dong-A University Hospital ( Site 3013)
Busan, Pusan-Kwangyokshi, 49201, South Korea
Keimyung University Dongsan Hospital CRC room 1 ( Site 3003)
Daegu, Taegu-Kwangyokshi, 42601, South Korea
Seoul National University Hospital ( Site 3001)
Seoul, 03080, South Korea
Kangbuk Samsung Hospital ( Site 3009)
Seoul, 03181, South Korea
Severance Hospital, Yonsei University Health System ( Site 3002)
Seoul, 03722, South Korea
Asan Medical Center ( Site 3004)
Seoul, 05505, South Korea
Samsung Medical Center-cardiology ( Site 3000)
Seoul, 06351, South Korea
The Catholic Univ. of Korea Seoul St. Mary's Hospital ( Site 3007)
Seoul, 06591, South Korea
Hospital Universitario de Torrevieja ( Site 2351)
Torrevieja, Alicante, 03186, Spain
Hospital Universitario Reina Sofia-Medicina Interna ( Site 2362)
Córdoba, Andalusia, 14004, Spain
Hospital Universitario Virgen de la Victoria-UGC Endocrinologia y nutricion ( Site 2323)
Málaga, Andalusia, 29010, Spain
Hospital Universitario Virgen de Valme-Internal Medicine ( Site 2336)
Seville, Andalusia, 41014, Spain
Corporació de Salut del Maresme i la Selva ( Site 2365)
Calella, Barcelona, 08370, Spain
Hospital Universitari Vall d'Hebron ( Site 2342)
Barcelona, Catalonia, 08035, Spain
EAP Osona Sud - Alt Congost S.L.P ( Site 2311)
Centelles, Catalonia, 08540, Spain
Hospital Universitari de Bellvitge-Unitat de Lipids i Risc Vascular ( Site 2327)
L'Hospitalet de Llobregat, Catalonia, 08907, Spain
CHUS - Hospital Clinico Universitario-Cardiology - Clinical Research Unit ( Site 2320)
Santiago de Compostela, La Coruna, 15706, Spain
Complejo Asistencial Universitario de León - Hospital de León ( Site 2339)
León, Leon, 24071, Spain
HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID-Endocrinologia y Nutrición ( Site 2344)
Pozuelo de Alarcón, Madrid, 28223, Spain
Hospital Universitario Fundacion ALcorcon ( Site 2353)
Alcorcón, Madrid, Comunidad de, 28922, Spain
Hospital Universitario Ramón y Cajal ( Site 2337)
Madrid, Madrid, Comunidad de, 28034, Spain
Hospital Universitario La Paz ( Site 2333)
Madrid, Madrid, Comunidad de, 28046, Spain
HOSPITAL UNIVERSITARIO PUERTA DE HIERRO MAJADAHONDA ( Site 2348)
Majadahonda, Madrid, Comunidad de, 28222, Spain
Hospital Clínico Universitario Virgen de la Arrixaca-CARDIOLOGÍA ( Site 2328)
El Palmar, Murcia, Murcia, Region de, 30120, Spain
Vithas Hospital Sevilla-Unidad de Salud Metabólica. Diabetes y Obesidad ( Site 2349)
Castilleja de la Cuesta, Sevilla, 41950, Spain
Hospital Universitari i Politecnic La Fe ( Site 2340)
Valencia, Valencia, 46026, Spain
HOSPITAL CLINICO DE VALENCIA-CARDIOLOGY ( Site 2321)
Valencia, Valenciana, Comunitat, 46010, Spain
Hospital La Luz ( Site 2366)
Madrid, 28003, Spain
Hospital La Princesa ( Site 2334)
Madrid, 28006, Spain
Hospital Clinico San Carlos-Cardiology ( Site 2325)
Madrid, 28040, Spain
Hospital Universitari Joan XXIII de Tarragona ( Site 2350)
Tarragona, 43005, Spain
Mackay Memorial Hospital -Tamsui Branch ( Site 3108)
New Taipei City, New Taipei, 251, Taiwan
Chi Mei Medical Center-Cardiology ( Site 3104)
Tainan, Tainan, 71004, Taiwan
Changhua Christian Hospital ( Site 3101)
Changhua, 50006, Taiwan
Kaohsiung Medical University Hospital ( Site 3109)
Kaohsiung City, 807, Taiwan
Chang Gung Memorial Hospital at Kaohsiung ( Site 3102)
Kaohsiung City, 83301, Taiwan
China Medical University Hospital ( Site 3103)
Taichung, 404332, Taiwan
National Taiwan University Hospital ( Site 3100)
Taipei, 10002, Taiwan
Taipei Medical University Hospital-Cardiology ( Site 3107)
Taipei, 110, Taiwan
Taipei Veterans General Hospital ( Site 3106)
Taipei, 112, Taiwan
Tri-Service General Hospital ( Site 3110)
Taipei, 114202, Taiwan
Hacettepe Universite Hastaneleri ( Site 2500)
Altindağ, Ankara, 06230, Turkey (Türkiye)
Ege Universitesi Hastanesi-Cardilogy Department ( Site 2502)
Bornova, İzmir, 35100, Turkey (Türkiye)
I.E.U. Medical Point Hastanesi ( Site 2521)
Cordaleo, İzmir, 35575, Turkey (Türkiye)
Erciyes Universitesi Tıp Fakultesi Hastaneleri-endocrine ( Site 2522)
Melikgazi, Kayseri, 38280, Turkey (Türkiye)
Adana Sehir Egitim ve Arastirma Hastanesi ( Site 2511)
Adana, 01370, Turkey (Türkiye)
SBÜ GÜLHANE EĞİTİM VE ARAŞTIRMA HASTANESİ ( Site 2524)
Ankara, 06010, Turkey (Türkiye)
Ankara Bilkent Şehir Hastanesi-cardiology ( Site 2501)
Ankara, 06800, Turkey (Türkiye)
Antalya Egitim ve Arastırma Hastanesi-Cardiology ( Site 2518)
Antalya, 07100, Turkey (Türkiye)
Çanakkale Onsekiz Mart Üniversitesi ( Site 2509)
Çanakkale, 17000, Turkey (Türkiye)
Trakya University ( Site 2523)
Edirne, 22030, Turkey (Türkiye)
Eskisehir Osmangazi University-Cardiology ( Site 2510)
Eskişehir, 26480, Turkey (Türkiye)
Istanbul University Cerrahpasa Medical School Internal Diseases Institute ( Site 2528)
Istanbul, 34098, Turkey (Türkiye)
Marmara Universitesi Pendik Egitim Arastirma Hastanesi ( Site 2520)
Istanbul, 34899, Turkey (Türkiye)
Kocaeli Üniversitesi-Cardiology ( Site 2516)
Kocaeli, 41380, Turkey (Türkiye)
NECMETTIN ERBAKAN MERAM MEDICAL FAC.-cardiology ( Site 2513)
Konya, 42080, Turkey (Türkiye)
İnönü Üniversitesi Turgut Özal Tıp Merkezi ( Site 2525)
Malatya, 44280, Turkey (Türkiye)
Ondokuz Mayis Universitesi Saglik Uygulama ve Arastirma Merkezi ( Site 2527)
Samsun, 55200, Turkey (Türkiye)
West Walk Surgery ( Site 2602)
Bristol, Bristol, City of, BS37 4AX, United Kingdom
Velocity Clinical Research Romford ( Site 2615)
Bristol, Bristol, City of, BS8 2RA, United Kingdom
Royal Devon & Exeter Hospital-Patient Recruitment Centre: Exeter ( Site 2605)
Exeter, Devon, EX2 5DW, United Kingdom
Walsall Manor Hospital ( Site 2600)
Walsall, Devon, WS2 9PS, United Kingdom
Barts Health NHS Trust-William Harvey Clinical Research Centre ( Site 2603)
London, England, EC1M 6BQ, United Kingdom
NIHR Commercial Recruitment Delivery Centre: Newcastle ( Site 2606)
Newcastle upon Tyne, England, NE1 4LP, United Kingdom
Golden Jubilee National Hospital ( Site 2613)
Clydebank, Glasgow City, G81 4DY, United Kingdom
Velocity Clinical Research Romford ( Site 2618)
Romford, London, City of, RM1 3PJ, United Kingdom
Lakeside Surgery ( Site 2601)
Corby, Northamptonshire, NN17 2UR, United Kingdom
Velocity Clinical Research, Leicester ( Site 2614)
Leicester, LE1 6NB, United Kingdom
Manchester Royal Infirmary ( Site 2612)
Manchester, M13 9WL, United Kingdom
Northern General Hospital ( Site 2611)
Sheffield, S5 7AU, United Kingdom
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Medical Director
Merck Sharp & Dohme LLC
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
- Masking Details
- The blinded period is double-blinded. The extension period is open-label.
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 17, 2023
First Posted
August 24, 2023
Study Start
October 9, 2023
Primary Completion (Estimated)
November 29, 2029
Study Completion (Estimated)
November 29, 2031
Last Updated
April 23, 2026
Record last verified: 2026-04
Data Sharing
- IPD Sharing
- Will share
https://trialstransparency.msdclinicaltrials.com/pdf/ProcedureAccessClinicalTrialData.pdf