Context Sensitivity in Emotion Regulation in Post-Traumatic Stress Disorder

NCT06007612 | Unknown

• 1 other identifier: Sheppes02
• Study Type: interventional
• Target: 96
• Locations: 1 country
• Sites: 1

Brief Summary

This study will examine context sensitivity, composed of two sequential elements: (a) accurate classification of changing affective contextual demands, followed by (b) flexible selection of regulatory strategies that matches changing contextual demands, among complex PTSD vs. Healthy controls.

Conditions

Complex Post-Traumatic Stress Disorder

Keywords

EMOTION REGULATION

Outcome Measures

Primary Outcomes (3)

• Difference in accurate intensity classification measured during Block A of the experiment

  comparing the accuracy in intensity classification of 80 words stimuli between the PTSD group and the control group.

  During the experimental task (1 hour)

• regulatory selection flexibility (distraction choice in high intensity minus distraction choice in low intensity) as assessed by regulatory selection paradigm

  group comparison of the association between accuracy in intensity classification (as measured in Block A) and regulatory selection flexibility (measured by the flexibility score which is calculated by subtracting the proportion of distraction selection in the low intensity stimuli (which reflects maladaptive behavior) from the proportion of distraction selection in the high intensity pictures (which reflects adaptive behavior) measured in Block B.

  During the experimental task (1 hour)

• regulatory selection flexibility (measured by distraction choice in high intensity minus distraction choice in low intensity) following provided intensity as assessed by regulatory selection paradigm

  group comparison of the association between provided intensity classification (i.e., whether stimuli is of high or low intensity) and regulatory selection flexibility (measured by the flexibility score which is calculated by subtracting the proportion of distraction selection in the low intensity stimuli (which reflects maladaptive behavior) from the proportion of distraction selection in the high intensity pictures (which reflects adaptive behavior) measured in Block C

  During the experimental task (1 hour)

Study Arms (1)

Behavioral: Context Sensitivity in Emotion Regulation

EXPERIMENTAL

Behavioral: Context Sensitivity in Emotion Regulation

Interventions

Context Sensitivity in Emotion Regulation BEHAVIORAL

Context Sensitivity of affective intensities and its association to Emotion Regulation Flexibility Selection

Behavioral: Context Sensitivity in Emotion Regulation

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Native Hebrew speakers
• age between 18 - 65
• normal or corrected to normal vision
• computer and internet access
• Group 1: Diagnosis of PTSD according to the DSM-5
• Group 2: GAD and PHQ scores (score\<10), no diagnosis of PTSD according to the DSM-5

You may not qualify if:

• Psychosis
• substance dependence or abuse other than nicotine
• Neurological condition

Sponsors & Collaborators

• Gal Sheppes: lead

Study Sites (1)

Tel Aviv University

Tel Aviv, 6997801, Israel

RECRUITING

MeSH Terms

Conditions

Emotional Regulation

Condition Hierarchy (Ancestors)

Self-Control; Social Behavior; Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator of Emotion Regulation Lab

Model Details: 2 groups enrolled in a one-time behavioral paradigm

Study Record Dates

• First Submitted: August 17, 2023
• First Posted: August 23, 2023
• Study Start: April 13, 2023
• Primary Completion: November 30, 2023
• Study Completion: November 30, 2023
• Last Updated: August 28, 2023

Record last verified: 2023-08

Locations

IL (1)