Prognostic Markers of Acute Heart Failure With Chronic Kidney Disease

NCT06006819 | Recruiting

• 1 other identifier: CHGH(983)111A-61
• Study Type: observational
• Target: 155
• Locations: 1 country
• Sites: 1

Brief Summary

Acute heart failure (AHF) is defined as new or worsening of symptoms and signs of heart failure and is the most frequent cause of unplanned hospital admission in elderly patients. N-terminal pro-brain natriuretic peptide (NT-pro-BNP) is one of the most developed prognostic markers for AHR patients and. NT-pro-BNP has limitations in terms of diagnostic or predictive accuracy in patients with chronic kidney disease (CKD). Plasma proteomics have the potential to examine underlying pathophysiological and prognostic roles, so we compared the plasma proteomic signature to predict outcomes of patients with or without CKD hospitalized for AHF.

Conditions

Chronic Kidney Diseases; Acute Heart Failure; Biomarker

Outcome Measures

Primary Outcomes (1)

• major adverse cardiovascular events

  mortality, acute myocardial infarction, acute stroke, and heart failure hospitalization

  1 year

Secondary Outcomes (1)

• major adverse kidney events

  1 year

Eligibility Criteria

• Age: 20 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Study participants were recruited from patients admitted to Cheng Hsin General Hospital with the major diagnosis of acute heart failure. After written informed consent was obtained (in compliance with the Helsinki Declaration), patients with age more than 20 were included. Exclusion criteria were initial serum NT-proBNP level \<300ng/ml, the presence of amputation, being pregnant, and receiving regular dialysis.

You may qualify if:

• hospitalized for acute heart failure

You may not qualify if:

• initial serum NT-proBNP level \<300ng/ml, pregnancy, amputated, and end-stage renal disease under regular dialysis

Sponsors & Collaborators

• Cheng-Hsin General Hospital: lead

Study Sites (1)

Cheng Hsin General Hospital

Taipei, Baitou District, 112, Taiwan

RECRUITING

MeSH Terms

Conditions

Renal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Shang Feng Yang, MD

  Cheng-Hsin General Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Shang Feng Yang, MD

CONTACT

+886-22826-4400; samyang1223@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Physician

Study Record Dates

• First Submitted: August 17, 2023
• First Posted: August 23, 2023
• Study Start: January 1, 2023
• Primary Completion: December 23, 2025
• Study Completion: December 23, 2025
• Last Updated: August 23, 2024

Record last verified: 2024-08

Locations

TW (1)