NCT06001866

Brief Summary

Children with developmental language disorder (DLD; also referred to as specific language impairment) experience a significant deficit in language ability that is longstanding and harmful to the children's academic, social, and eventual economic wellbeing. Word learning is one of the principal weaknesses in these children. This project focuses on the word learning abilities of four- and five-year-old children with DLD. The goal of the project is to build on the investigators' previous work to determine whether, as has been found thus far, special benefits accrue when these children must frequently recall newly introduced words during the course of learning. The focus of the current study is verb-learning. The goal of the study is to increase children's absolute levels of verb learning while maintaining the advantage that repeated retrieval holds over comparison methods of learning.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
31

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Mar 2023

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2023

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

August 3, 2023

Completed
18 days until next milestone

First Posted

Study publicly available on registry

August 21, 2023

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 25, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 25, 2024

Completed
1.6 years until next milestone

Results Posted

Study results publicly available

August 13, 2025

Completed
Last Updated

August 13, 2025

Status Verified

July 1, 2025

Enrollment Period

11 months

First QC Date

August 3, 2023

Results QC Date

July 5, 2025

Last Update Submit

July 25, 2025

Conditions

Keywords

word learningword retrievalpreschool-aged children

Outcome Measures

Primary Outcomes (7)

  • Verb Recall Accuracy (Number of Verbs Correctly Recalled) in Repeated Spaced Retrieval (RSR) and Repeated Study (RS) Conditions at 5 Mins. for Learned Items

    Five minutes after second learning session, child is asked to recall and say the word associated with each novel action learned under each of the two conditions: a condition in which spaced retrieval trials occurred and one in which there were no retrieval trials. For Learned items, each of the four verbs was tested with videos of two of the agent-object pairs the child had seen during the learning period, for a total of 8 recall items. Children were prompted to retrieve/produce the novel verbs in the sentence structure used during learning.

    5 minutes after end of Day 2 (second day) learning period.

  • Verb Recall Accuracy (Number of Verbs Correctly Recalled) in Repeated Spaced Retrieval (RSR) and Repeated Study (RS) Conditions at 5 Mins. for Generalized Items

    Five minutes after second learning session, child is asked to recall and say the word associated with each novel action learned under one of two conditions: a condition in which spaced retrieval trials occurred and one in which there were no retrieval trials. For Generalized items each of the four verbs was tested with videos of two agent-object pairs that were new (that the child had not seen during the learning period), for a total of 8 recall items. Children were prompted to retrieve/produce the novel verbs in the sentence structure used during learning.

    5 minutes after end of Day 2 (second day) learning period.

  • Verb Recall Accuracy (Number of Verbs Correctly Recalled) in Repeated Spaced Retrieval (RSR) and Repeated Study (RS) Conditions at 1 Week for Learned Items.

    One week after second learning session, child is asked to recall and say the word associated with each novel action learned under one of two conditions: a condition in which spaced retrieval trials occurred and one in which there were no retrieval trials. For Learned items, each of the four verbs was tested with videos of two of the agent-object pairs the child had seen during the learning period, for a total of 8 recall items. Children were prompted to retrieve/produce the novel verbs in the sentence structure used during learning.

    1 week after Day 2 (second day) learning period.

  • Verb Recall Accuracy (Number of Verbs Correctly Recalled) in Repeated Spaced Retrieval (RSR) and Repeated Study (RS) Conditions at 1 Week for Generalized Items

    One week after second learning session, child is asked to recall and say the word associated with each novel action learned under one of two conditions: a condition in which spaced retrieval trials occurred and one in which there were no retrieval trials. For Generalized items, each of the four verbs was tested with videos of two agent-object pairs that were new (that the child had not seen during the learning period), for a total of 8 recall items. Children were prompted to retrieve/produce the novel verbs in the sentence structure used during learning.

    1 week after Day 2 (second day) learning period.

  • Accuracy of Verb Recall (Number of Verbs Correctly Recalled) in a New Structure in Repeated Spaced Retrieval (RSR) and Repeated Study (RS) Conditions

    Child is asked to describe the video of a novel action using the novel verb in a frame different from the one learned (i.e.,"X likes to VERB the Y") in repeated spaced retrieval and repeated study conditions. Each verb is tested with four items: three items made use of videos of agent-object pairs the child had seen during the learning period and one item used an agent-object pair that was new. There were eight items total per condition.

    1 week after Day 2 (second day) learning period.

  • Verb Recognition (Number of Words Accurately Identified) in Repeated Spaced Retrieval (RSR) and Repeated Study (RS) Conditions for Learned Items.

    One week after the learning session, child is asked to indicate (by pointing) which of 2 video options is referred to upon hearing a sentence using a novel word learned in either the repeated spaced retrieval or repeated study condition. Each verb is tested with two items which used videos of agent-object pairs that the child had seen during the learning period, for a total of eight items.

    1 week after Day 2 (second day) learning period.

  • Verb Recognition (Number of Words Accurately Identified) in Repeated Spaced Retrieval (RSR) and Repeated Study (RS) Conditions for Generalized Items.

    One week after the learning session, child is asked to indicate (by pointing) which of 2 video options is referred to upon hearing a sentence using a novel word learned in either the repeated spaced retrieval or repeated study condition. Each verb is tested with two items which used videos of agent-object pairs that were new (that the child had not seen during the learning period), for a total of eight items.

    1 week after Day 2 (second day) learning period.

Secondary Outcomes (2)

  • Peabody Picture Vocabulary Test, Fifth Edition

    Test completed at start of study

  • Maternal Education in Years

    information collected at start of study

Study Arms (2)

Children with Developmental Language Disorder

EXPERIMENTAL

These children have a significant delay in language development in the absence of hearing impairment, cognitive delay, autism, or neurological injury/disease.

Behavioral: Retrieval-based verb learning: Repeated Spaced Retrieval conditionBehavioral: Retrieval-based verb learning: Repeated Study condition

Children with typical language development

EXPERIMENTAL

Children whose language development is as expected for their age.

Behavioral: Retrieval-based verb learning: Repeated Spaced Retrieval conditionBehavioral: Retrieval-based verb learning: Repeated Study condition

Interventions

A set of novel verbs are practiced on 2 consecutive days (the same verbs are used each day). Half of the novel verbs are learned in the repeated spaced retrieval condition and half are learned in the repeated study condition, with the two conditions interleaved on each day. The repeated spaced retrieval condition consists of study and retrieval trials. At the start of the sessions, retrieval trials immediately follow study trials. Thereafter, retrieval trials are spaced for each verb, occurring after 3 other words have intervened between the retrieval trial and the last study trial for that verb.

Children with Developmental Language DisorderChildren with typical language development

A set of novel verbs are practiced on 2 consecutive days (the same verbs are used each day). Half of the novel verbs are learned in the repeated spaced retrieval condition and half are learned in the repeated study condition, with the two conditions interleaved on each day. The repeated study condition consists of study trials only (with no retrieval practice).

Children with Developmental Language DisorderChildren with typical language development

Eligibility Criteria

Age48 Months - 71 Months
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • a significant deficit in language ability (language test score below cutoff for best sensitivity/specificity) or documented age-appropriate language ability.
  • normal hearing no evidence of neurological damage or disease scores on tests of nonverbal intelligence above the intellectual disability range not within Autistic range on Autism screening test native English speaker (can be bilingual)

You may not qualify if:

  • failed hearing screening known neurological damage or disease scores on tests of nonverbal intelligence below the intellectual disability range (standard score less than 75) autism spectrum disorder non-native English speaker

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Purdue University

West Lafayette, Indiana, 47907, United States

Location

MeSH Terms

Conditions

Language Development DisordersSpecific Language Disorder

Condition Hierarchy (Ancestors)

Language DisordersCommunication DisordersNeurobehavioral ManifestationsNeurologic ManifestationsNervous System DiseasesSigns and SymptomsPathological Conditions, Signs and SymptomsLearning DisabilitiesNeurodevelopmental DisordersMental Disorders

Results Point of Contact

Title
Dr. Patricia Deevy, Research Associate
Organization
Purdue University

Study Officials

  • Laurence B. Leonard, PhD

    Purdue Universtiy

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
FACTORIAL
Model Details: Within-participant design in which each child learns words under two conditions.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor of Speech, Language, & Hearing Sciences

Study Record Dates

First Submitted

August 3, 2023

First Posted

August 21, 2023

Study Start

March 1, 2023

Primary Completion

January 25, 2024

Study Completion

January 25, 2024

Last Updated

August 13, 2025

Results First Posted

August 13, 2025

Record last verified: 2025-07

Data Sharing

IPD Sharing
Will share

Data that contribute to our final published results will be made available at www.clinicaltrials.gov.

Shared Documents
STUDY PROTOCOL, SAP, ICF
Time Frame
Data will become available after the results are published or within 12 months from the primary completion date (i.e., the date of final data collection for the primary outcome measure).
Access Criteria
De-identified data will be made publicly available at www.clinicaltrials.gov

Locations