Cardiac Troponin Fragmentation After Heavy Physical Exercise The MaraCat2 Study

NCT06000930 | Enrolling By Invitation

• 1 other identifier: 13.06.2023/207
• Study Type: observational
• Target: 170
• Locations: 1 country
• Sites: 1

Brief Summary

Cardiac troponins are highly sensitive and specific biomarkers of cardiac injury and are in a key role in the diagnosis of acute myocardial infarction (MI). Minor troponin elevations are common after prolonged strenuous exercise without clinical symptoms of MI or myocardial injury. Importantly, currently used high-sensitivity troponin T (cTnT) test detects also smaller troponin fragments which may cause troponin elevation after exercise and lead to false diagnosis of MI. In the present study protocol, we compare the characteristics troponin release after marathon race and Type 1 MI with the improved version of our novel troponin fragmentation test (SuperTropo test) and the commercial cTnT test. A total of 65 recreational runners participating in the 2023 Paavo Nurmi Marathon in Turku are recruited. All participants give a blood sample during the post-race visit (within 30 min after finishing the marathon). A control group of 90 patients with acute Type 1 MI are recruited among patients admitted to Heart Centre of Turku University Hospital. Commercial cTnT and long troponin component of cTnT analyzed witha novel immunoassay are dtermined in all subjects to assess cTnT fragmentation. TYhe main aims of the study are: To assess how often cTnT is elevated after marathon running and which factors affect the cTnT rise? Is the fragmentation of troponin more common after marathon race compared with Type 1 MI and can the novel Supertropo test separate execise-induced troponin rise from those caused by MI ?

Conditions

Myocardial Infarction; Myocardial Injury

Keywords

exercise; troponin; myocardial infarction; myocardial injury

Outcome Measures

Primary Outcomes (1)

• Magnitude of Troponin fragmentation in the post-race and post-MI (<24h) blood samples

  Ratio of long troponin component to total troponin T in the post-race and post-MI (\<24h) blood sample

  < 1 hour after marathon race and < 24 hours after myocardial infarction

Study Arms (2)

marathon runners

Marathon runners

Diagnostic Test: Troponin fragmentation

myocardial infarction

Patients with Type 1 myocardial infarction

Diagnostic Test: Troponin fragmentation

Interventions

Troponin fragmentation DIAGNOSTIC_TEST

laboratory test from blood sample

marathon runners; myocardial infarction

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Marathon runners and patients with acute myocardial infarction as a control group

You may qualify if:

• participating marathon race or treated for Type 1 myocardial infarction and giving informed consent

Sponsors & Collaborators

• University of Turku: lead
• Turku University Hospital: collaborator

Study Sites (1)

University of Turku

Turku, 20300, Finland

Location

Related Publications (1)

• Airaksinen KEJ, Paana T, Vasankari T, Salonen S, Tuominen T, Linko-Parvinen A, Pallari HM, Hellman T, Teppo K, Heinonen OJ, Jaakkola S, Wittfooth S. Composition of cardiac troponin release differs after marathon running and myocardial infarction. Open Heart. 2024 Nov 17;11(2):e002954. doi: 10.1136/openhrt-2024-002954.

  PMID: 39551608 DERIVED

MeSH Terms

Conditions

Myocardial Infarction; Motor Activity

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis; Behavior

Study Officials

• Juhani K Airaksinen, Md, PhD

  Turku University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: August 13, 2023
• First Posted: August 21, 2023
• Study Start: August 19, 2023
• Primary Completion: September 1, 2024
• Study Completion: September 1, 2024
• Last Updated: May 8, 2024

Record last verified: 2024-05

Locations

FI (1)