NCT06000865|Recruiting
Glaucoma Rehabilitation With Action viDeo Games and Exercise - GRADE
The GRADE Randomized Trial: Glaucoma Rehabilitation With Action viDeo Games and Exercise
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The GRADE Randomized Trial: Glaucoma Rehabilitation With Action viDeo Games and Exercise
Sponsor study identifier
interventional
56
1 country
1
Study Start
September 9, 2023
Actual (reported)Primary Completion
July 30, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 30, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Falls are one of the most serious public health concerns for seniors, with significant medical and economic consequences. This concern is even higher in patients with peripheral field loss due to glaucoma because of the patients' compromised visual input. The investigators' project proposes an innovative, entertaining, easily accessible and enjoyable intervention for improving mobility and postural control function in glaucoma patients with peripheral vision loss, who are more prone to falls and suffer from fear of falling. The new intervention examined in this project can be implemented in current vision and balance rehabilitation programs, and may benefit patients with different types of visual impairment to minimize their risk of falls and improve their quality of life.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 30, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
September 25, 2022
Actual (reported)August 21, 2023
Actual (reported)September 9, 2023
Actual (reported)July 30, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
December 30, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Gait Measure - Time Up and Go test combining Narrow path walking test
Time Up and Go test combining Narrow path walking test: All participants need to stand up from a 46 cm height chair, walk on the path at their usual pace until the strip of a non-reflective tape, cross over the tape, turn 180°, walk to the starting position and finally sit down. Then repeat the same procedure within a narrower width. Participants need to use the dominant leg to step onto the standing position on one force plate while the non-dominant leg stands on the other force plate. The test will repeat for 10 times. Participants' gait parameters including hip flexion/extension (degree), knee Min/Max (degree), ankle flexion/extension (degree), walking speed (mm/s), step width (mm), and step length(mm) will be measured and analyzed for each condition.
Change from baseline at week 5 and change from baseline at week 10.
Static Balance Measure
Change from baseline at week 5 and change from baseline at week 10.
Perturbed Balance Measure
Change from baseline at week 5 and change from baseline at week 10.
Useful field of view (UFOV)
Change from baseline at week 5 and change from baseline at week 10.
Reaction time (RT)
Change from baseline at week 5 and change from baseline at week 10.
Cognitive Reflection Test
Change from baseline at week 5 and change from baseline at week 10.
AVG using a Nintendo Switch gaming station will be administered in 20 sessions over 10 weeks (45 minutes per session, 2 sessions per week). Participants will be in standing position with game controllers or sensors attached to the body while playing games involving muscle stretching and strengthening exercises.
Participants in the PT will receive 45-minutes conventional physical training.
20 sessions of AVG over 10 weeks (45 minutes per session, 2 sessions per week)
20 sessions of physical training over 10 weeks (45 minutes per session, 2 sessions per week)
The Hong Kong Polytechnic University
Hong Kong, Hong Kong, 000000, Hong Kong
Yihong P, Thompson B, Winser S, Lau I, Suen V, Cheung M, Cheong AMY. Glaucoma rehabilitation with action video games and exercise: study protocol of an active-controlled trial (GRADE). BMJ Open. 2025 Sep 17;15(9):e105971. doi: 10.1136/bmjopen-2025-105971.
Allen Cheong, PhD
The Hong Kong Polytechnic University
First Submitted
September 25, 2022
First Posted
August 21, 2023
Study Start
September 9, 2023
Actual (reported)Primary Completion
July 30, 2025
Estimated (date passed)Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to confirm eligibility.
This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 30, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
July 28, 2025
Record last verified: 2025-03
IPD that underlie results in a publication will be available upon reasonable request to the research team.
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Source: ClinicalTrials.gov.
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