NCT06000670

Brief Summary

clinical efficacy of autologous stromal vascular fraction SVF,for inflammatory and degenerative conditions of the knees

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
300

participants targeted

Target at P75+ for not_applicable knee-osteoarthritis

Timeline
23mo left

Started Dec 2026

Typical duration for not_applicable knee-osteoarthritis

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 2, 2023

Completed
19 days until next milestone

First Posted

Study publicly available on registry

August 21, 2023

Completed
3.4 years until next milestone

Study Start

First participant enrolled

December 30, 2026

Expected
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 30, 2027

11 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2028

Last Updated

August 26, 2025

Status Verified

August 1, 2025

Enrollment Period

1 year

First QC Date

August 2, 2023

Last Update Submit

August 20, 2025

Conditions

Knee Osteoarthritis

Keywords

knee osteoarthritisknee chondromalacia

Outcome Measures

Primary Outcomes (1)

  • change in pain level

    visual analog scale 0-10 ( 10 being worst)

    2 years

Secondary Outcomes (1)

  • percentage cartilage thickness change

    2 years

Study Arms (1)

knee osteoarhritis

EXPERIMENTAL

patients with grade 2 and above chondromlacia as well as all grades of osteoarhtritis

Procedure: stromal vascular fraction injection in the osteoarthritic knee

Interventions

stromal vascular fraction injection in the osteoarthritic kneePROCEDURE

stromal vascular fraction harvested from mid abdominal wall under sedation and seperated from fat using mechanical centrifugation .injection of 5 cc of the SVF in the affected knee.

knee osteoarhritis

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • knee osteoarthritis any grade
  • knee chondromalacia grade 2 and above

You may not qualify if:

  • active HIV
  • pregnant women
  • Mental disease
  • severe cardio vascular disease
  • severe coagulation disorders
  • infected tissues
  • patients on other experimental studies within 3 months

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Links

MeSH Terms

Conditions

Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

OsteoarthritisArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic Diseases

Study Officials

  • DHA DHA

    dubai health autority

    STUDY DIRECTOR

Central Study Contacts

Amer Mansour, MD

CONTACT

+971502983375dramermansour@gmail.com

mazen sawaf, MD

CONTACT

+971504545266drmax@novomed.com

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Masking Details
investigator is blinded to clinical and radiological assessments .
Purpose
OTHER
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER GOV
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
consultant orthopedic surgeon

Study Record Dates

First Submitted

August 2, 2023

First Posted

August 21, 2023

Study Start (Estimated)

December 30, 2026

Primary Completion (Estimated)

December 30, 2027

Study Completion (Estimated)

December 1, 2028

Last Updated

August 26, 2025

Record last verified: 2025-08

Data Sharing

IPD Sharing
Will not share