Enhancing Memory in CPT for PTSD
Enhancing Memory in Cognitive Processing Therapy for Older Adults With PTSD
2 other identifiers
interventional
30
1 country
1
Brief Summary
Several psychotherapies for posttraumatic stress disorder (PTSD) have a strong evidence base for their efficacy, but nonresponse rates are high, particularly among older Veterans. Accumulating evidence indicates that memory deficits and poor learning of therapy contents adversely affect psychotherapy treatment response in PTSD. However, limited research has examined methods for increasing learning of therapy contents in psychotherapy for PTSD. The proposed study aims to examine the feasibility of integrating an intervention to increase learning and memory of psychotherapy content into the provision of a widely used psychotherapy, cognitive processing therapy (CPT), for older adults with PTSD. The ultimate goal of this line of research is to develop novel rehabilitation interventions to increase functioning for individuals with PTSD.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Oct 2024
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 11, 2023
CompletedFirst Posted
Study publicly available on registry
August 21, 2023
CompletedStudy Start
First participant enrolled
October 15, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 30, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
June 30, 2026
October 14, 2025
October 1, 2025
1.7 years
August 11, 2023
October 9, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
PTSD Checklist-5 (PCL-5)
Questionnaire for symptoms of PTSD; the range of the scale is from 0 (no symptoms) to 80 (maximal symptoms).
Through study completion, weeks 12-16 of treatment
Other Outcomes (1)
Client Satisfaction Questionnaire (CSQ)
Through study completion, weeks 12-16 of treatment
Study Arms (2)
Cognitive Processing Therapy (CPT)
ACTIVE COMPARATORStandard CPT as described in the treatment manual
Cognitive Processing Therapy (CPT) + Memory Support
EXPERIMENTALCPT+Memory support will also incorporate frequent and intentional use of strategies to enhance learning and memory of this content.
Interventions
CPT as described in the treatment manual
CPT+Memory support will also incorporate frequent and intentional use of strategies to enhance learning and memory of this content.
Eligibility Criteria
You may qualify if:
- Veterans with DSM-5 diagnoses of PTSD via the Clinician Administered PTSD Scale (CAPS-5)
- Age \>59
You may not qualify if:
- daily benzodiazepine use (due to memory impairing effects)
- bipolar or psychotic disorders
- current suicidal ideation with plan or intent
- current moderate or severe substance use disorder not in remission for \>1 mo.
- severe traumatic brain injury
- a Montreal Cognitive Assessment (MoCA) indicative of dementia
- or other disorders that would severely limit study participation
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA
Philadelphia, Pennsylvania, 19104-4551, United States
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
James C. Scott, PhD
Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
- Masking Details
- Blinded to treatment status during feasibility trial
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- FED
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 11, 2023
First Posted
August 21, 2023
Study Start
October 15, 2024
Primary Completion (Estimated)
June 30, 2026
Study Completion (Estimated)
June 30, 2026
Last Updated
October 14, 2025
Record last verified: 2025-10
Data Sharing
- IPD Sharing
- Will not share