Evaluation of Oxidative Stress and Inflammation Markers in Temporomandibular Disorders

NCT05985733 | Completed

• 1 other identifier: PYO.DIS.1904.17.018
• Study Type: observational
• Target: 44
• Locations: 1 country
• Sites: 1

Brief Summary

Background: The occurrence of many diseases has been associated with oxidative stress and disruption of antioxidant mechanisms. Temporomandibular Joint(TMJ) Disorders are also thought to develop with the onset of the destructive process in the tissues as a result of this balance being disrupted. Purpose: This study was designed to compare salivary and serum oxidative stress and inflammation markers of individuals with Temporomandibular Disorders (TMD) and healthy subjects. Study design, setting, and sample: A prospective cross-sectional study was conducted. 27 TMD patients diagnosed with disc displacement (DD) according to RDC/TMD and 17 healthy subjects were enrolled in the study. Prior to any treatment, serum and saliva samples were taken from the patients and centrifuged, and stored at -80°C until analyzed. All samples were examined for IL-6, MDA and 8-OHdG concentrations. Predictor variable: Diagnosis of disc displacement (RDC/TMD) Main outcome variables: Levels of 8-OHdG, IL-6 and MDA Covariates: Age and gender

Conditions

Temporomandibular Disorder; Oxidative Stress; Inflammation

Outcome Measures

Primary Outcomes (1)

• relationship between serum and salivary 8-OHdG, IL-6 and MDA levels

  relationship between serum and salivary 8-OHdG, IL-6 and MDA levels and Temporomandibular Disorders were evaluated

  through study completion, an average of 1 year

Study Arms (2)

Study group

patients who applied to our clinic with complaint of pain in TMJ region subjects who had RDC/TMD type II disorder

Other: Biochemical analysis

Control group

age and sex matched healthy volunteers

Other: Biochemical analysis

Interventions

Biochemical analysis OTHER

Oxidative stress and inflammation markers were analyzed in serum and saliva of TMD and healthy subjects.

Control group; Study group

Eligibility Criteria

• Age: 14 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

TMD subjects who had RDC/TMD type II disorder (TMJ disc displacement (DD) with reduction, TMJ-DD without reduction with limited opening, TMJ-DD without reduction without limited opening) and, age and sex matched volunteers were included as the control group

You may qualify if:

• TMD subjects who had RDC/TMD type II disorder (TMJ disc displacement (DD) with reduction
• TMJ-DD without reduction with limited opening
• TMJ-DD without reduction without limited opening)

You may not qualify if:

• other local or systemic diseases,
• pain of dental origin,
• pregnancy or lactation,
• story of the use of anti-inflammatory drugs, analgesics, muscle relaxants, vitamin C or vitamin E,
• smoking,
• individuals who had already been under treatment for TMD

Sponsors & Collaborators

• Bahçeşehir University: lead

Study Sites (1)

Bahcesehir University

Istanbul, Beşiktaş, 34357, Turkey (Türkiye)

Location

Biospecimen

Retention: SAMPLES WITH DNA

saliva serum

MeSH Terms

Conditions

Temporomandibular Joint Disorders; Inflammation

Condition Hierarchy (Ancestors)

Craniomandibular Disorders; Mandibular Diseases; Jaw Diseases; Musculoskeletal Diseases; Joint Diseases; Muscular Diseases; Stomatognathic Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Dilara Kazan

  Bahçeşehir University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: July 26, 2023
• First Posted: August 14, 2023
• Study Start: June 19, 2020
• Primary Completion: March 28, 2023
• Study Completion: April 19, 2023
• Last Updated: August 14, 2023

Record last verified: 2023-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)