Steroid Injection for Sickle Cell Arthropathy Pain Therapy

NCT05983055 | Completed

• 1 other identifier: SalemAn2018 SCD arthro injectn
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Sickle cell disease (SCD) is associated with arthropathy. Arthropathy may require periarticular corticosteroid injection therapy. This observational study examines efficacy, and safety of steroid injections in SCD patients. Data collection includes patient's gender, age, race, smoking history, alcohol intake, analgesic use, pain score, sleep quality, limb joint injections, post-injection analgesia, and post-injection complication. Pain is measured using numeric pain scale. Sleep quality is measured using Likert scale.

Conditions

Sickle Cell Disease; Sickle Cell Abnormality

Keywords

Sickle cell

Outcome Measures

Primary Outcomes (1)

• Numeric pain score, objective measurement using validated Numeric Pain Rating scale

  Pain score, using the Numeric Pain Rating scale of 0 to 10, low scores indicate less pain, high scores indicate worse pain

  12 weeks

Secondary Outcomes (1)

• Sleep quality score, objective measurement using validated Likert sleep scale

  12 weeks

Interventions

Dexamethasone 20mg DRUG

Periarticular dexamethasone injection

Also known as: Dexamethasone injection

Eligibility Criteria

• Age: 20 Years - 99 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

A cohort of consecutive adult patients who underwent pain management at a pain clinic

You may qualify if:

• adult chronic pain patients
• sickle cell disease arthropathy
• periarticular steroid injection therapy
• regular sleep diary
• regular pain diary
• informed consent for therapy and diary review

You may not qualify if:

• pediatric patients
• patient without sickle cell disease arthropathy
• patient without periarticular steroid injection
• irregular sleep diary
• irregular pain diary

Sponsors & Collaborators

• Salem Anaesthesia Pain Clinic: lead

Study Sites (1)

Salem Anaesthesia Pain Clinic

Surrey, British Columbia, V3S 7J1, Canada

Location

MeSH Terms

Conditions

Anemia, Sickle Cell

Interventions

Dexamethasone; Calcium Dobesilate

Condition Hierarchy (Ancestors)

Anemia, Hemolytic, Congenital; Anemia, Hemolytic; Anemia; Hematologic Diseases; Hemic and Lymphatic Diseases; Hemoglobinopathies; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Intervention Hierarchy (Ancestors)

Pregnadienetriols; Pregnadienes; Pregnanes; Steroids; Fused-Ring Compounds; Polycyclic Compounds; Steroids, Fluorinated; Benzenesulfonates; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons; Organic Chemicals; Arylsulfonates; Arylsulfonic Acids; Sulfonic Acids; Sulfur Acids; Sulfur Compounds

Study Officials

• Olumuyiwa Bamgbade, MD,FRCPC

  Salem Anaesthesia Pain Clinic

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 1, 2023
• First Posted: August 9, 2023
• Study Start: January 30, 2018
• Primary Completion: March 31, 2024
• Study Completion: March 31, 2024
• Last Updated: January 27, 2025

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)