Impact of Emotional Reactivity on Dysfunctional Decision-Making in NSSI Adolescents

NCT05981612 | Recruiting

• 1 other identifier: BAM_lab_NSSI_04
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Nonsuicidal self-injury (NSSI) is defined as direct, intentional physical injury without suicidal intention. Studies revealed that dysfunctional interpersonal relationships and reward-related decision-making may play crucial roles in this maladaptive behavior, especially in adolescents. These interpersonal decision contexts are characterized by constant updating of expectations of rewards and the actual received rewards as well as the associated emotional reactions. These processes have recently been computationally formalized as prediction errors (PE), specifically reward PEs, valence PEs, and arousal PEs (Heffner et al., 2021; Nat Hum Behav). In the current study, the investigators aim to investigate whether these PEs make discernible contributions to social decisions in the context of unfair experiences among adolescents with NSSI and matched healthy control adolescents (HC). Specifically the investigators hypothesized that: 1) reward and emotional PEs show significant predictions of punishment decisions in both groups, 2) however, compared to HC adolescents, the NSSI group will exhibit selective dysfunctions in emotional but not reward PEs leading to punish a norm proposer who provided unfair offers.

Conditions

Nonsuicidal Self Injury; Prediction Errors

Outcome Measures

Primary Outcomes (4)

• Reward prediction errors (PEs)

  Reward PEs will be calculated by the differences between the experienced (when be offered) reward and predicted (before the offer) reward.

  About 20 minutes

• Valence prediction errors (PEs)

  Valence PEs will be calculated by the differences between the experienced emotional valence and predicted emotional valence.

  About 20 minutes

• Arousal prediction errors (PEs)

  Arousal PEs will be calculated by the differences between the experienced emotional arousal and predicted emotional arousal.

  About 20 minutes

• The prediction of PEs of punishment decisions

  All PEs and groups (NSSI, HC) will be used in a regression model to examined whether there is any alteration in the NSSI group when PEs are predicted to punishment (reject) decisions.

  About 20 minutes

Study Arms (2)

NSSI

HC

Eligibility Criteria

• Age: 15 Years - 18 Years
• Sex: all
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Treatment-seeking NSSI individuals will be recruited from local hospitals and HC from the community.

You may qualify if:

• years
• right-handed
• normal or corrected normal visual acuity
• meet the proposed DSM-5 frequency criteria (e.g., ≥5 days of NSSI behaviors in the past year)

You may not qualify if:

• diagnosis of borderline personality disorder, major depressive disorder, other
• psychiatric disorders, etc.
• high suicidal risk
• recent use of medications that can affect neural activity
• have received or are receiving Dialectical Behavior Therapy (DBT) other treatment for emotional problems within the past 6 months
• have a contraindication to MRI scanning (e.g., metal implants, claustrophobia or other conditions that make them inappropriate for MRI scanning)

Sponsors & Collaborators

• University of Electronic Science and Technology of China: lead

Study Sites (1)

Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China

Chengdu, Sichuan, China

RECRUITING

MeSH Terms

Conditions

Self-Injurious Behavior

Condition Hierarchy (Ancestors)

Behavioral Symptoms; Behavior

Central Study Contacts

Benjamin Becker

CONTACT

+86.028-61830867; ben_becker@gmx.de

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: July 20, 2023
• First Posted: August 8, 2023
• Study Start: December 6, 2023
• Primary Completion (Estimated): July 1, 2026
• Study Completion (Estimated): July 1, 2027
• Last Updated: April 11, 2024

Record last verified: 2024-04

Locations

CN (1)