Visual Perception Difficulties After Stroke

NCT05981482 | Recruiting

• 1 other identifier: Durham University
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 3

Brief Summary

The goal of this observational study is to learn how well the Oxford Visual Perception Screening (OxVPS) tool can identify stroke survivors with visual perception difficulties. The main aim is to determine the accuracy and utility of the OxVPS compared to the current gold standard assessment in stroke survivors. In other words, how well can the Oxford Visual Perception Screening tool (OxVPS) identify stroke patients with visual perception problems? Participants will completed the OxVPS and the current gold standards visual perception screening tool.

Conditions

Stroke; Visual Perception

Outcome Measures

Primary Outcomes (2)

• Validity of OxVPS

  Convergent and discriminate validity will be assessed. Convergent validity expressed as a correlation between total score on OxVPS and RPAB. Discriminate validity to be expressed as correlation between OxVPS score and scores of cognitive and sensory vision assessments. Both calculated by a non-parametric Spearman correlation and estimate a 95% confidence interval. The analysis can be completed through the cor.test function in the base package of R.

  All testing completed in 2 weeks

• Reliability of OxVPS

  The inter-rater reliability of OxVPS will be evaluated through a Bland-Altman analysis \[26\]: we will calculate the difference in OxVPS scores between raters for each patient. Subsequently, we will plot the difference in scores as a function on the average score to evaluate a bias between the raters (mean difference) that might vary based on severity of a patient's visual perceptual problems. We will report the mean difference, standard deviation, and limits of agreement within where 95% of differences between raters fall. A t-test will indicate if the mean difference is significantly different from 0. Analyses will be performed in R with the functions from blandr package (e.g. blandr.statistics and blandr.draw) or functions from a similar package.

  2 weeks

Study Arms (1)

Stroke survivors

Individuals who have survived a stroke

Diagnostic Test: OxVPS

Interventions

OxVPS DIAGNOSTIC_TEST

Comparing a new screening tool, the Oxford visual perception screening, to the gold standard, Rivermead Perceptual Battery Assessment.

Stroke survivors

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Stroke survivors on stroke rehabilitation units in the North East of England and Oxfordshire.

You may qualify if:

• Patients with a clinical diagnosis of stroke (ischemic stroke and/or intracerebral haemorrhage).
• Within 6 weeks of confirmed stroke.

You may not qualify if:

• Insufficient understanding of English
• Clinical concerns that patient is unable follow simple instructions.
• Clinical concerns that patient is unable to concentrate for 15 minutes.
• No capacity to provide informed consent.

Sponsors & Collaborators

• Durham University: lead
• National Institute for Health Research, United Kingdom: collaborator
• County Durham and Darlington NHS Foundation Trust: collaborator
• University of Oxford: collaborator

Study Sites (3)

Abingdon Community Hospital

Abingdon, OX14 1AG, United Kingdom

RECRUITING

Bishop Auckland Hospital

Bishop Auckland, DL14 6AD, United Kingdom

RECRUITING

Queen Elizabeth Hospital

Gateshead, NE9 6SX, United Kingdom

RECRUITING

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Kathleen Vancleef, PhD

  Durham University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Kate Cowen, PhD

CONTACT

441913343275; kate.cowen@durham.ac.uk

Kathleen Vancleef, PhD

CONTACT

441913340108; kathleen.vancleef@durham.ac.uk

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Postdoc researcher

Study Record Dates

• First Submitted: July 31, 2023
• First Posted: August 8, 2023
• Study Start: June 20, 2023
• Primary Completion: August 31, 2024
• Study Completion: February 28, 2026
• Last Updated: August 6, 2024

Record last verified: 2024-08

Data Sharing

• IPD Sharing: Will not share

Locations

GB (3)