Thyroid Profiles in Patients With Acute Illness

NCT05980923 | Withdrawn

• 1 other identifier: DCR2023/1.ThyrAcuteIll
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

Patients admitted to the hospital with acute illness may have a wide spectrum of thyroid function abnormalities. It is largely unknown whether such aberrations are temporary or persist for a long time, and whether they impact prognosis of such patients.

Conditions

Thyroid Dysfunction; Acute Illness

Keywords

Thyroid abnormalities; Acute illness; Prognosis; Middle east

Outcome Measures

Primary Outcomes (1)

• In hospital mortality

  All-cause death rate in patients with abnormal thyroid function compared with death in those with no abnormal thyroid function during the patients hospital stay..

  From time of study entry until the date of death from any cause, assessed up to 2 weeks.

Secondary Outcomes (1)

• 6-month mortality rate

  From date of study entry until the date of death from any cause, assessed up to two weeks.

Study Arms (2)

GROUP 1: Acute illness and abnormal thyroid function

Patients admitted to the hospital with acute illness and found to have thyroid function abnormalities.

Other: Performing blood thyroid test (TSH, FT4, FT3)

GROUP 2: Acute illness and normal thyroid function

Patients admitted to the hospital with acute illness and found to have normal thyroid function.

Other: Performing blood thyroid test (TSH, FT4, FT3)

Interventions

Performing blood thyroid test (TSH, FT4, FT3) OTHER

Blood test as above

GROUP 1: Acute illness and abnormal thyroid function; GROUP 2: Acute illness and normal thyroid function

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

nclusion Criteria: All patients admitted to the hospital with acute illness will have their serum level of thyroid stimulating hormone and free T4 and T3 measured on admission. Clinical and laboratory profiles of patients with abnormal thyroid function (Group 1) will be compared to those with normal thyroid function (Group 2). Serum thyroid test will be repeated at 6 months. Short and long term survival of both groups will be compared as well. Diagnosis on admission is acute illness includes: heart failure, acute coronary syndrome, sepsis, acute stroke, hypotension, acute system-organ failure including renal and hepatic failure.

You may qualify if:

• Hospital admission
• Adults aged 18 years and above
• Willing to sign an informed consent
• Diagnosis on admission is acute illness that includes: heart failure, acute coronary syndrome, sepsis, acute stroke, hypotension, acute system-organ failure including renal and hepatic failure.

You may not qualify if:

• Age less than 18 years.
• Refusal to sign consent.
• Admission for a reason not classified as acute illness.

Sponsors & Collaborators

• Jordan Collaborating Cardiology Group: lead

Study Sites (1)

Istishari Hospital

Amman, 11888, Jordan

Location

MeSH Terms

Conditions

Thyroid Diseases

Interventions

Thyrotropin

Condition Hierarchy (Ancestors)

Endocrine System Diseases

Intervention Hierarchy (Ancestors)

Pituitary Hormones, Anterior; Pituitary Hormones; Peptide Hormones; Hormones; Hormones, Hormone Substitutes, and Hormone Antagonists; Peptides; Amino Acids, Peptides, and Proteins

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 20, 2023
• First Posted: August 8, 2023
• Study Start: October 15, 2023
• Primary Completion: January 15, 2025
• Study Completion: January 30, 2025
• Last Updated: February 25, 2025

Record last verified: 2025-02

Locations

JO (1)