Time Course of a Misperception of Verticality and Its Characteristics in Post-stroke Participants

NCT05978596 | Unknown

• 1 other identifier: CvdW
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 2

Brief Summary

Little is known about the time course of verticality perception after stroke. This study aims to assess:

• The time course of verticality perception (Subjective Visual, Haptic and Postural Vertical; resp., SVV, SHV, SPV);
• The longitudinal interaction of the recovery of spatial disorders (e.g., different types of neglect, lateropulsion) with verticality perception;
• The longitudinal interaction of motor function and outcomes (such as paresis, sitting balance and standing balance) and verticality perception. The participants will be repetitively assessed during the subacute phase post-stroke, to evaluate the time course of:
• The SVV, SHV and SPV;
• Spatial disorders (visuospatial and personal neglect, lateropulsion)
• Motor function (lower limb strength, sitting and standing balance, functionality in ADL, trunk performance)

Conditions

Stroke

Keywords

Perception of verticality; Spatial neglect; Lateropulsion; Postural control; Subjective Visual Vertical; Subjective Haptic Vertical; Subjective Postural Vertical

Outcome Measures

Primary Outcomes (27)

• Change in Subjective Visual Vertical constant error

  Reflects the difference between the perceived visual vertical and the gravitational vector, with the direction (ipsi- vs contralesional) considered.

  Change from 3 to 5 weeks

• Change in Subjective Visual Vertical constant error

  Reflects the difference between the perceived visual vertical and the gravitational vector, with the direction (ipsi- vs contralesional) considered.

  Change from 5 to 8 weeks

• Change in Subjective Visual Vertical constant error

  Reflects the difference between the perceived visual vertical and the gravitational vector, with the direction (ipsi- vs contralesional) considered.

  Change from 8 to 12

• Change in Subjective Hapic Vertical constant error

  Reflects the difference between the perceived haptic vertical and the gravitational vector, with the direction (ipsi- vs contralesional) considered.

  Change from 3 to 5 weeks

• Change in Subjective Hapic Vertical constant error

  Reflects the difference between the perceived haptic vertical and the gravitational vector, with the direction (ipsi- vs contralesional) considered.

  Change from 5 to 8 weeks

• Change in Subjective Hapic Vertical constant error

  Reflects the difference between the perceived haptic vertical and the gravitational vector, with the direction (ipsi- vs contralesional) considered.

  Change from 8 to 12 weeks

• Change in Subjective Postural Vertical constant error

  Reflects the difference between the perceived postural vertical and the gravitational vector, with the direction (ipsi- vs contralesional) considered.

  Change from 3 to 5 weeks

• Change in Subjective Postural Vertical constant error

  Reflects the difference between the perceived postural vertical and the gravitational vector, with the direction (ipsi- vs contralesional) considered.

  Change from 5 to 8 weeks

• Change in Subjective Postural Vertical constant error

  Reflects the difference between the perceived postural vertical and the gravitational vector, with the direction (ipsi- vs contralesional) considered.

  Change from 8 to 12 weeks

• Change in Subjective Visual Vertical unsigned error

  Reflects the difference between the perceived visual vertical and the gravitational vector, irrespective of the direction.

  Change from 3 to 5 weeks

• Change in Subjective Visual Vertical unsigned error

  Reflects the difference between the perceived visual vertical and the gravitational vector, irrespective of the direction.

  Change from 5 to 8 weeks

• Change in Subjective Visual Vertical unsigned error

  Reflects the difference between the perceived visual vertical and the gravitational vector, irrespective of the direction.

  Change from 8 to 12 weeks

• Change in Subjective Haptic Vertical unsigned error

  Reflects the difference between the perceived haptic vertical and the gravitational vector, irrespective of the direction.

  Change from 3 to 5 weeks

• Change in Subjective Haptic Vertical unsigned error

  Reflects the difference between the perceived haptic vertical and the gravitational vector, irrespective of the direction.

  Change from 5 to 8 weeks

• Change in Subjective Haptic Vertical unsigned error

  Reflects the difference between the perceived haptic vertical and the gravitational vector, irrespective of the direction.

  Change from 8 to 12 weeks

• Change in Subjective Postural Vertical unsigned error

  Reflects the difference between the perceived postural vertical and the gravitational vector, irrespective of the direction.

  Change from 3 to 5 weeks

• Change in Subjective Postural Vertical unsigned error

  Reflects the difference between the perceived postural vertical and the gravitational vector, irrespective of the direction.

  Change from 5 to 8 weeks

• Change in Subjective Postural Vertical unsigned error

  Reflects the difference between the perceived postural vertical and the gravitational vector, irrespective of the direction.

  Change from 8 to 12 weeks

• Change in Subjective Visual Vertical variability

  Reflects the intra-individual variability (standard deviation of the trials)

  Change from 3 to 5 weeks

• Change in Subjective Visual Vertical variability

  Reflects the intra-individual variability (standard deviation of the trials)

  Change from 5 to 8 weeks

• Change in Subjective Visual Vertical variability

  Reflects the intra-individual variability (standard deviation of the trials)

  Change from 8 to 12 weeks

• Change in Subjective Haptic Vertical variability

  Reflects the intra-individual variability (standard deviation of the trials)

  Change from 3 to 5 weeks

• Change in Subjective Haptic Vertical variability

  Reflects the intra-individual variability (standard deviation of the trials)

  Change from 5 to 8 weeks

• Change in Subjective Haptic Vertical variability

  Reflects the intra-individual variability (standard deviation of the trials)

  Change from 8 to 12 weeks

• Change in Subjective Postural Vertical variability

  Reflects the intra-individual variability (standard deviation of the trials)

  Change from 3 to 5 weeks

• Change in Subjective Postural Vertical variability

  Reflects the intra-individual variability (standard deviation of the trials)

  Change from 5 to 8 weeks

• Change in Subjective Postural Vertical variability

  Reflects the intra-individual variability (standard deviation of the trials)

  Change from 8 to 12 weeks

Secondary Outcomes (12)

• Trunk Control Test - item quiet siting for 30 seconds

  3, 5, 8, 12 weeks post-stroke

• Berg Balance Scale - item quiet standing for 2 minutes

  3, 5, 8, 12 weeks post-stroke

• Motricity index - lower limbs

  3, 5, 8, 12 weeks post-stroke

• Line Bisection Test

  3, 5, 8, 12 weeks post-stroke

• Visuospatial Search Time Test

  3, 5, 8, 12 weeks post-stroke

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Participants will be recruited from rehabiliation hospital RevArte (Edegem) and AZ Monica (Antwerp).

You may qualify if:

• First-ever, MRI- or CT-confirmed, ischemic or hemorrhagic supratentorial stroke;
• Able to give written informed consent.

You may not qualify if:

• Bilateral lesions;
• Vestibular dysfunction, symptomatic orthostatic hypotension or other pre-existing neurological conditions that could interfere with the assessments;
• Inability to understand and follow basic verbal instructions;
• Hemianopsia or other visual field deficits (glasses or corrective lenses are allowed)

Sponsors & Collaborators

• Universiteit Antwerpen: lead

Study Sites (2)

AZ Monica

Antwerp, 2018, Belgium

RECRUITING

RevArte

Edegem, 2650, Belgium

RECRUITING

Related Publications (5)

• van der Waal C, Embrechts E, Loureiro-Chaves R, Gebruers N, Truijen S, Saeys W. Lateropulsion with active pushing in stroke patients: its link with lesion location and the perception of verticality. A systematic review. Top Stroke Rehabil. 2023 Apr;30(3):281-297. doi: 10.1080/10749357.2022.2026563. Epub 2022 Feb 1.

  PMID: 35102816 BACKGROUND

• Embrechts E, van der Waal C, Anseeuw D, van Buijnderen J, Leroij A, Lafosse C, Nijboer TC, Truijen S, Saeys W. Association between spatial neglect and impaired verticality perception after stroke: A systematic review. Ann Phys Rehabil Med. 2023 Apr;66(3):101700. doi: 10.1016/j.rehab.2022.101700. Epub 2022 Dec 1.

  PMID: 35963568 BACKGROUND

• Perennou DA, Mazibrada G, Chauvineau V, Greenwood R, Rothwell J, Gresty MA, Bronstein AM. Lateropulsion, pushing and verticality perception in hemisphere stroke: a causal relationship? Brain. 2008 Sep;131(Pt 9):2401-13. doi: 10.1093/brain/awn170. Epub 2008 Aug 4.

  PMID: 18678565 BACKGROUND

• Bonan IV, Leman MC, Legargasson JF, Guichard JP, Yelnik AP. Evolution of subjective visual vertical perturbation after stroke. Neurorehabil Neural Repair. 2006 Dec;20(4):484-91. doi: 10.1177/1545968306289295.

  PMID: 17082504 BACKGROUND

• van der Waal C, Saeys W, Truijen S, Embrechts E. Clinical Assessment of Subjective Visual and Haptic Vertical Norms in Healthy Adults. Arch Clin Neuropsychol. 2024 Nov 22;39(8):1408-1417. doi: 10.1093/arclin/acae049.

  PMID: 38940374 DERIVED

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Wim Saeys, Prof. Dr.

  Universiteit Antwerpen

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Charlotte van der Waal, MSc

CONTACT

+3232659724; charlotte.vanderwaal@uantwerpen.be

Wim Saeys, Prof. Dr.

CONTACT

wim.saeys@uantwerpen.be

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor Dr. Wim Saeys

Study Record Dates

• First Submitted: June 20, 2023
• First Posted: August 7, 2023
• Study Start: October 1, 2021
• Primary Completion: December 1, 2024
• Study Completion: December 1, 2024
• Last Updated: August 7, 2023

Record last verified: 2023-08

Locations

BE (2)