The Effect of IEQ on Cognition and Health

NCT05972187 | Completed DMC

• 1 other identifier: NL81104.068.22
• Study Type: interventional
• Target: 22
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this study is to learn about the effect of heat and humidity on cognition and health. The main question\[s\] it aims to answer are: type of study: interventional participant population: 20-40years, both gender, healthy Participants will be exposed for 4 different sessions of 8 hours at a time, to 32˚ C or 25˚ C in combination with relative humidity of 30 %RH or 70 %RH.

Conditions

Environmental Exposure; Temperature Change, Body; Condition; Healthy

Keywords

Temperature; Humidity; Thermoregulation; Cognition; Health

Outcome Measures

Primary Outcomes (1)

• Cognition

  Using a tablet based cognitive test battery

  1 month

Secondary Outcomes (5)

• Heart Rate (bpm)

  1 month

• Blood pressure (mmHg)

  1 month

• Metabolic Rate (ml O2//min/kg)

  1 month

• Skin Temperature (C)

  1 month

• Body Core Temperature (C)

  1 month

Other Outcomes (2)

• Room Temperature (C)

  1 month

• Humidity (%)

  1 month

Study Arms (1)

Temperature and Humidity

EXPERIMENTAL

32C or 25C and 30%RH or 70%RH

Other: Temperature and Humidity

Interventions

Temperature and Humidity OTHER

Temperature and Humidity of room changed

Temperature and Humidity

Eligibility Criteria

• Age: 20 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• BMI between 18.5-26 kg/m2
• Age between 20-40 years
• Proficient with the English language in both verbal and written form
• Healthy; no illness or disease or prescribed medication within the last 3 months
• Steady dietary and sleeping habits
• Regularly physically active (i.e., regularly active but less than 3 times a week for less than 2 hours per session at moderate intensity)
• Non-smoker or person who quit smoking more than five years ago
• Reside in the Netherlands (or surrounding countries) for at least 6 months

You may not qualify if:

• Subjects with cardiac problems and cardiovascular diseases, such as angina pectoris, cardiac infarction, and arrhythmias
• Subjects with any medical condition requiring treatment and/or medication (except oral contraceptives) that might interfere with the investigated parameters E.g., Extreme chronotype, colour blindness, epilepsy
• Subjects with a disorder or disease (Parkinson, Attention Deficit Hyperactivity Disorder (ADHD), Alzheimer, diabetes, cardiovascular disorder, respiratory impairments (for example asthma), hypertension, obesity, or any other condition that can impair the lung function), or Raynaud's phenomenon
• Subjects with abnormal diet and sleeping patters and/or abnormal body weight (weight gain or loss \>3kg in the past month)
• Subjects who recently participated in other interventional biomedical study within 1 month prior to screening visit
• Subjects, who do not want to be informed about unexpected medical findings, or do not wish that their treating physician will be informed, cannot participate in this study
• Subjects with previous covid infection in the past 3 months or any subject with persistent long covid symptoms that may have caused ongoing loss of or altered sense of smell
• Subjects who had severely altered sleep patterns in the past year
• Subjects employed with night shift work within the past year
• Subjects who consume more than two standard drinks of alcohol per day
• Subjects who consume more than two standard drinks of coffee per day
• Subjects who are pregnant

Sponsors & Collaborators

• Maastricht University Medical Center: lead

Study Sites (1)

Maastricht University

Maastricht, Netherlands

Location

MeSH Terms

Conditions

Body Temperature Changes; Disease

Interventions

Temperature; Humidity

Condition Hierarchy (Ancestors)

Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Pathologic Processes

Intervention Hierarchy (Ancestors)

Thermodynamics; Physical Phenomena; Weather; Atmosphere; Environment; Ecological and Environmental Phenomena; Biological Phenomena; Meteorological Concepts; Environment, Controlled; Environment and Public Health

Study Officials

• Guy Plasqui, PHD

  Maastricht University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 24, 2023
• First Posted: August 2, 2023
• Study Start: June 18, 2023
• Primary Completion: May 7, 2024
• Study Completion: May 7, 2024
• Last Updated: March 24, 2025

Record last verified: 2023-09

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ANALYTIC CODE
• Time Frame: Ongoing, depends on the request.
• Access Criteria: Official request made stating the purpose of use for the data. Only individuals that consent to their data to be used in further analysis will be shared.

Locations

NL (1)