BCAAs, Muscle Protein Synthesis and Glucose Uptake

NCT06218264 | Completed

• 1 other identifier: NL82984.028.23
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

The present study aims to quantify the insulin sensitivity and the skeletal muscle protein synthetic response to consuming a test drink containing all amino acids or all amino acids except for BCAAs.

Conditions

Healthy

Outcome Measures

Primary Outcomes (1)

• Postprandial muscle protein synthesis

  Muscle protein synthesis rate (FSR) prior to and following ingestion of an amino acid drink

  4 hours

Secondary Outcomes (3)

• Forearm muscle glucose uptake

  7.5 hours

• Whole-body insulin sensitivity

  Four hours following ingestion of an amino acid drink

• Forearm amino acid kinetics

  Prior to and for 4 hours following amino acid intake

Study Arms (2)

FullAA

ACTIVE COMPARATOR

Amino acid drink containing all amino acids

Dietary Supplement: Ingestion of an amino acid supplement

NoBCAA

ACTIVE COMPARATOR

Amino acid drink containing all amino acids except for BCAAs.

Dietary Supplement: Ingestion of an amino acid supplement

Interventions

Ingestion of an amino acid supplement DIETARY_SUPPLEMENT

Oral intake of a supplement containing amino acids

FullAA; NoBCAA

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Aged from 18-35 years
• \< Body mass index \< 30 kg·m2
• Recreationally active (performing non-competitive physical exercise at least one time per week for minimally 30 minutes)

You may not qualify if:

• Smoking
• Diabetes (Type 1, Type 2, or genetic form of diabetes)
• Any diagnosed cardiovascular (heart) disease or high blood pressure (≥140 mmHg systolic and/or ≥90 mmHg diastolic)
• Chronic use of any prescribed or over the counter pharmaceuticals (excluding oral contraceptives and contraceptive devices)
• Known allergy to lidocaine
• Regular use of dietary protein and/or amino acid supplements (\>3 times per week)
• Currently involved in a structured progressive resistance training programme (\>3 times per week)
• A personal or family history of thrombosis (clots), epilepsy, seizures, or schizophrenia.
• Any previous motor disorders or disorders in muscle and/or lipid metabolism
• Presence of an ulcer in the stomach or gut and/or strong history of indigestion
• Known severe kidney problems
• Pregnant or breastfeeding
• Unable to give consent

Sponsors & Collaborators

• Wageningen University: lead

Study Sites (1)

Wageningen University and Research

Wageningen, Gelderland, 6708 WD, Netherlands

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: January 11, 2024
• First Posted: January 23, 2024
• Study Start: January 10, 2024
• Primary Completion: February 13, 2026
• Study Completion: February 13, 2026
• Last Updated: February 20, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

NL (1)