Effect Of Whole Body Vibration Versus Weight Bearing Exercises On Osteoporosis In Breast Cancer Patients After Chemotherapy

NCT05970250 | Completed DMC

• 1 other identifier: Eman Mahrous Abdel-Hamed Ahmed
• Study Type: interventional
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

Chemotherapy can damage bone marrow and therefore impair the production of white blood cells, platelets and red blood cells with the resulting anemia and osteoporosis.

Conditions

Osteoporosis; Breast Cancer

Outcome Measures

Primary Outcomes (1)

• Assessing the change in bone mineral density

  By using DEXA (dual-energy X-ray absorptiometry): Dual-energy X-ray absorptiometry (DEXA) is a clinically proven method of measuring bone mineral density (BMD) in the lumbar spine, proximal femur, forearm, and whole body. It is used primarily in the diagnosis and management of osteoporosis and other disease states characterized by abnormal BMD, as well as to monitor response to therapy for these conditions .

  at baseline and after 2 months of intervention

Study Arms (3)

Whole body vibration group

EXPERIMENTAL

In this group (the first study group) fifteen breast cancer patients after receiving chemotherapy within 3-6 months and complaining from osteoporosis were received the whole body vibration, 20 minutes 3 times per week for 2 months and drug therapy (vitamin D supplements and calcium).

Other: Whole body vibration group; Drug: vitamin D supplements and calcium

Weight bearing exercises group

EXPERIMENTAL

In this group (the second study group) fifteen breast cancer patients after receiving chemotherapy within 3-6 months and complaining from osteoporosis were received aerobic exercise on treadmill as form of weight bearing exercise 20 minutes 3 times per week for 2 months and drug therapy (vitamin D supplements and calcium).

Other: Weight bearing exercises; Drug: vitamin D supplements and calcium

drug therapy group

OTHER

In this group (control group) fifteen breast cancer patients after receiving chemotherapy within 3-6 months and complaining from osteoporosis were received only drug therapy (vitamin D supplements and calcium. Measurements were conducted before starting the treatment as a first record, at end of the second month of treatment as second record and make follow up after 3 months as final record.

Drug: vitamin D supplements and calcium

Interventions

Whole body vibration group OTHER

Whole body vibration apparatus (model Power plate -my5tm, made in United States) with frequency 30 - 40 Hz was used for the whole body vibration program by reciprocating vertical displacements on the left and right side of a fulcrum.

Whole body vibration group

Weight bearing exercises OTHER

Electronic treadmill Kettler- marathon model No 7899-800, made in Germany (as form of weight bearing exercises), which was adjusted to the subject's comfortable walking speed. Generally, during the treadmill training, its speed and inclination are electronically adjusted, and it is also provided with a control panel to display the exercise parameters. It allows for the comfortable running without joint or back pains through a perfect combination between aluminium-pertinax running deck, shock absorbers and overall shock-damping design.

Weight bearing exercises group

vitamin D supplements and calcium DRUG

vitamin D supplements and calcium

Weight bearing exercises group; Whole body vibration group; drug therapy group

Eligibility Criteria

• Age: 35 Years - 55 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Breast cancer patients after receiving chemotherapy within 3-6 months and complaining from osteoporosis.
• Their age ranges from 35-55 years old.
• All patients will have the same medical and nursing care.
• All the patients will receive a good explanation of treatment and measurement device.
• They are neurologically free.

You may not qualify if:

• Patients will be excluded from this study for any of the following causes:
• Uncooperative patients.
• Instability of patient's medical condition.
• Association of another medical problem.
• Patients who have diabetes.
• Patients who have history of medical chronic relevant diseases.
• Patients who have acute or chronic hepatitis.
• Patients who have pacemaker.
• Patients who have genitourinary infections.

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Outpatient clinic faculty of physical therapy cairo university

Dokki, Egypt

Location

MeSH Terms

Conditions

Osteoporosis; Breast Neoplasms

Interventions

Calcium

Condition Hierarchy (Ancestors)

Bone Diseases, Metabolic; Bone Diseases; Musculoskeletal Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases; Neoplasms by Site; Neoplasms; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases

Intervention Hierarchy (Ancestors)

Metals, Alkaline Earth; Elements; Inorganic Chemicals; Metals; Blood Coagulation Factors; Biological Factors

Study Officials

• Eman Elgendy

  Cairo University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: July 24, 2023
• First Posted: August 1, 2023
• Study Start: January 20, 2022
• Primary Completion: April 20, 2022
• Study Completion: July 20, 2022
• Last Updated: August 1, 2023

Record last verified: 2023-07

Locations

EG (1)