Effection of Total Knee Arthroplasty on Knee Joint

NCT05965765 | Completed

• 1 other identifier: E-41901325-200-57879
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to evaluate the joint position sense of individuals diagnosed with knee osteoarthritis and who have undergone unilateral total knee arthroplasty surgery, and to examine the effect of joint position sense on parameters related to balance, physical performance, reaction time, kinesiophobia, pain and stiffness. Answered the question of the relationship between knee joint position sense, balance, physical performance, reaction time, kinesiophobia levels, pain, stiffness and function in individuals who have undergone knee arthroplasty. Answered the question of the relationship between knee joint position sense, balance, physical performance, reaction time, kinesiophobia levels, pain, stiffness and function in individuals diagnosed with knee OA who have not undergone surgery. Answered the question of whether there is a difference between the knee joint position sense values, balance, physical performance, reaction time, kinesiophobia levels, pain, stiffness and function of individuals who have undergone Knee Arthroplasty, individuals diagnosed with Knee OA and healthy individuals.

Conditions

Total Knee Arthroplasty

Keywords

Arthroplasty; Equilibrium; Knee; Knee joint; Knee prosthesis; Recovery of function; Osteoarthritis; Osteoarthritis-knee; Proprioception; Reaction time

Outcome Measures

Primary Outcomes (6)

• Knee Position Sense

  Knee joint position sense will be evaluated with the mobile application. As the target angle, 15˚, 45˚ and 60˚ knee flexion positions will be determined. For the initial target angle of 15˚ knee flexion, the physiotherapist will passively bring the individual's knee to 15˚ knee flexion and remain in this position for 5 seconds. The individual will be asked to feel and remember this angle, and when he thinks he has come to this angle during the test, he will be asked to say "here" by keeping his knee fixed at that angle. The "estimated target angle" that the person perceives as the "target angle" will be recorded with the phone application. For a target angle, the average of the 3 measurements will be recorded. The deviation angle between the taught target angle and the estimated target angle made by the individual will be calculated.

  baseline

• Balance

  Berg Balance scale, which has Turkish validity and reliability, will be used in the evaluation of balance. Scale; It consists of 14 parameters that evaluate sitting, standing and standing. These parameters are scored between 0 (unable) and 4 (doing safely). The maximum score is 56. As the score decreases, it will be interpreted as the risk of falling increases and the balance is poor.

  baseline

• Reaction Time

  Nelson Foot Reaction Test will be used to evaluate the reaction rate. Individuals will be asked to remove their shoes and sit on the stool. The dominant side will be positioned so that the toe is 2.5 cm away from the wall and the heel is 5 cm away from the wall. The observer will hold the 30 cm long wooden ruler on the wall and at the level of the dominant toe of the individual to be evaluated, count backwards from three, one by one and say zero, and leave the ruler. The individual will be asked to hold the falling ruler with the toe and the value on the tip of the foot at the moment he catches the ruler will be recorded in centimeters. The test will be repeated 5 times, and the average of the 3 values other than the lowest and highest values will be recorded in centimeters. The average value obtained will be put into the formula "Reaction Time= √2 x Distance (cm)/980 cm/s2" and the reaction time will be calculated and recorded in seconds.

  baseline

• Physical Performance

  Timed Up \& Go Test (TIGT): This test is frequently used in the evaluation of functional status in individuals with OA and its original name is "Timed Up \& Go Test" (TUG). During this test, individuals will be asked to get up from a chair with fixed arms while sitting with their feet in contact with the floor, walk 3 meters, return from the marked place at the end of 3 meters, walk back to the chair and sit on the chair. The duration will be started as soon as the hips of the individuals are out of contact with the chair and stopped when their hips come into contact with the chair after they return, and will be recorded in seconds with a stopwatch.

  baseline

• Kinesiophobia

  Tampa Kinesiophobia Scale will be used in the evaluation of kinesiophobia. The Tampa Kinesiophobia Scale is a 17-question checklist. It is scored between 1 and 4 points on a Likert scale (1 answer I strongly disagree, 4 answer I strongly agree), 4,8,12,16. The calculation of the questions is done by inverting. The score is determined in the range of 17-68 points, and as the score increases, the fear of movement also increases.

  baseline

• Evaluation of Pain, Function, and Stiffness

  WOMAC index in order to determine the severity of the clinical findings in the cases and the effects of the current clinical picture on the daily living activities of the patients; osteoarthritis index will be evaluated. WOMAC consists of 3 parts and 24 questions. There are 5 questions in the pain section, 2 questions in the stiffness section, and 17 questions in the physical function section. The total WOMAC value will be obtained by scoring the answers given by the patients as none/mild/moderate/severe/extreme, respectively, between 0 and 4 points. Then, the scores of each section will be collected within itself and the score for that section will be found. High WOMAC values indicate an increase in pain and stiffness and deterioration in physical function. As a result of the study examining the acceptability, reliability, validity and sensitivity of the Turkish version of the WOMAC OA index, it was shown that the Turkish version of the WOMAC index had good content validity.

  baseline

Study Arms (3)

Total Knee Arthroplasty

EXPERIMENTAL

Individuals who have previously undergone Unilateral total knee arthroplasty

Diagnostic Test: Total knee arthroplasty

Osteoarthritis without surgery

EXPERIMENTAL

According to Kellgren-Lawrence, individuals diagnosed with osteoarthritis between II and IV

Diagnostic Test: osteoarthritis without surgery

Control Group

ACTIVE COMPARATOR

healthy individuals who have not had any knee problems in the last 6 months

Diagnostic Test: control group

Interventions

Total knee arthroplasty DIAGNOSTIC_TEST

who got total knee arthroplasty because of osteoarthritis

Total Knee Arthroplasty

osteoarthritis without surgery DIAGNOSTIC_TEST

who has osteoarthritis and didn't get any surgery

Osteoarthritis without surgery

control group DIAGNOSTIC_TEST

healthy people

Control Group

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• FOR THE GROUP WITH KNEE ARTROPLASTY SURGERY:
• Be over the age of 40
• Having previously undergone unilateral total knee arthroplasty and at least 3 months have passed since
• Volunteer
• FOR GROUP WITH KNEE OSTEOARTHRITIS:
• Be over the age of 40
• Being diagnosed with OA clinically and radiologically (Kellgren-Lawrence II-IV)
• Not having been exposed to any surgical intervention for the knee Not having received intra-articular injection of the knee in the last 3 months.
• Volunteer
• FOR THE GROUP OF HEALTHY VOLUNTEERS:
• Be over the age of 40 Not having knee OA or any knee disease No complaints of knee pain in the last 6 months
• Volunteer

You may not qualify if:

• For all groups:
• Previous knee surgery (People who have undergone replantation surgery)
• Individuals who have had lower extremity surgery
• Pregnancy or lactation Those with lower extremity fractures
• Those with sensory defects
• Those diagnosed with malignancy Those with incompletely healed fractures
• Those with circulatory disorders Those who have infection in the areas around the knee joint
• Those with metal implants
• Cancer patients known to be life-threatening
• People with severe hearing loss or visual impairment
• People with communication problems Those with uncontrollably high blood pressure People with vestibular problems such as vertigo and balance problems
• Patients who want to leave the study
• Patients who cannot continue to work due to developing additional disease

Sponsors & Collaborators

• KTO Karatay University: lead

Study Sites (1)

KTO Karatay University

Konya, Turkey (Türkiye)

Location

Related Publications (1)

• Yurttas AN, Araci A, Akkoyun Sert O, Ismayilov T. Investigation of knee joint position sensation balance reaction time and function in individuals with knee osteoarthritis and unilateral total knee arthroplasty. J Back Musculoskelet Rehabil. 2025 Oct 27:10538127251387392. doi: 10.1177/10538127251387392. Online ahead of print.

  PMID: 41143951 DERIVED

MeSH Terms

Conditions

Osteoarthritis; Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Study Officials

• Ayşe Nihal YURTTAŞ, master

  KTO Karatay University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Asistant,Physiotherapist

Study Record Dates

• First Submitted: July 20, 2023
• First Posted: July 28, 2023
• Study Start: May 4, 2023
• Primary Completion: July 20, 2023
• Study Completion: July 30, 2023
• Last Updated: February 11, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)