Characteristics of Hoffa Adipose Tissue and Intramuscular Adipose Tissue in the Quadriceps Muscle

NCT05955976 | Unknown

• 1 other identifier: 23Rhumato02
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Over the last few years, it has been suggested that Knee Ostheoarthritis (KOA) incidence and progression could potentially be related to skeletal muscle characteristics. In particular, weakness of the quadriceps muscle would be a key determinant of KOA. However the mechanisms underpinning the influence of skeletal muscle in the pathophysiology of ostheoarthritis (OA) are poorly understood. Crosstalk between skeletal muscle and structures around and in the joint is of interest. In physical deconditioning and aging, it has been reported that skeletal muscle can be replaced by adipose tissue. Several factors involved in the development of OA but also of adipose tissue may be involved in these muscular changes. Of interest, in patients with KOA, quadriceps weakness is an ubiquitous clinical finding. Infiltration of adipose tissue in skeletal muscle has been shown to affect muscle strength and mobility and be linked to cartilage volume loss and the occurrence/progression of KOA. The main objective of this study is to compare the characteristics of the Hoffa tissus and the intamuscular fat (IMF) tissus in the quadriceps muscle in patients with gonarthrosis requiring total knee prosthesis. This is a single-centre study based on a collection of surgical waste and is categorized as Research Not Involving Human subjects.

Conditions

Osteo Arthritis Knee

Outcome Measures

Primary Outcomes (3)

• Comparison between Hoffa tissue and intramuscular fat tissue (quadriceps): adipose tissue size differences

  size mesured in mm

  4 months

• Comparison between Hoffa tissue and intramuscular fat tissue (quadriceps): lipid levels

  level mesured in %

  4 months

• Comparison between Hoffa tissue and intramuscular fat tissue (quadriceps):fibrotic tissue

  rate mesured in %

  4 months

Study Arms (1)

Patients suffering of knee ostheoarthritis undergoing a surgery for a total knee prosthesis.

Other: BIOPSY

Interventions

BIOPSY OTHER

biopsy

Patients suffering of knee ostheoarthritis undergoing a surgery for a total knee prosthesis.

Eligibility Criteria

• Age: 40 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients aged between 40 and 85 years that have a scheduled surgery for a total knee prosthesis and have a confirmed diagnosis of knee ostheoarthritis.

You may qualify if:

• Adult patient, aged between 40 and 85 years
• Patient having a confirmed diagnosis of knee ostheoarthritis
• Patient undergoing a surgery for a total knee prosthesis for knee ostheoarthritis

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Nice: lead

Study Sites (1)

Nice University Hospital

Nice, 06000, France

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Hoffa tissue (1 cm x 1 cm) and intramuscular fat tissue (1 cm x 1 cm)

MeSH Terms

Interventions

Biopsy

Intervention Hierarchy (Ancestors)

Cytodiagnosis; Cytological Techniques; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Specimen Handling; Diagnostic Techniques, Surgical; Surgical Procedures, Operative; Investigative Techniques

Central Study Contacts

Christian ROUX, PUPH

CONTACT

0492035491; roux.c2@chu-nice.fr

Jean-François GONCALVEZ, PUPH

CONTACT

0492035963; gonzalez.jf@chu-nice.fr

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 13, 2023
• First Posted: July 21, 2023
• Study Start: July 20, 2023
• Primary Completion: September 20, 2023
• Study Completion: March 20, 2024
• Last Updated: July 25, 2023

Record last verified: 2023-07

Locations

FR (1)