Effect of Blood Flow Restriction Training to Muscle Strength, Dynamic Stability, and ACL Injury Prevention

NCT05951036 | Completed DMC

• 1 other identifier: 1575/UN14.2.2.VII.14/LT/2023
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this randomized clinical trial study is to compare low-load blood flow restriction (LL-BFRt), sham LL-BFRt, and high-load eccentric training (HL-Et) in healthy level 1 sportsman. The main questions it aims to answer are:

• In LL-BFRt, participants will be asked to do LL eccentric training (including double leg squats, split squats, deadlifts, and monster walks) with a 30% of repetition maximum (RM) and 70% of arterial occlusion pressure (AOP).
• In sham LL-BFRt, participants will be asked to do LL eccentric training with a 30% of repetition maximum (RM) and 10% of arterial occlusion pressure (AOP).
• In HL-Et, participants will be asked to do LL eccentric training with a 70% of repetition maximum (RM). Researchers will compare LL-BFRt, sham LL-BFRt, and HL-Et to see if muscle strength, dynamic stability, and ACL injury prevention improve after the interventions and follow-up.

Conditions

Healthy Subjects; Sports Level 1

Keywords

blood flow restriction training; sham blood flow restriction training; BFR; Eccentric training

Outcome Measures

Primary Outcomes (3)

• Muscle strength

  Investigators will measure the quadriceps muscle isometric strength using dynamometer (units: Newton or kilogram).

  8 weeks

• Dynamic stability I

  Investigators will measure the dynamic stability I using Y-balance test (units: centimeter).

  8 weeks

• Dynamic stability II

  Investigators will measure the dynamic stability II using single leg hop test (units: centimeter).

  8 weeks

Study Arms (3)

LL-BFRt

EXPERIMENTAL

30% of repetition maximum and 70% of arterial occlusion pressure

Procedure: Low-load Blood Flow Restriction training

Sham LL-BFRt

SHAM COMPARATOR

30% of repetition maximum and 10% of arterial occlusion pressure

Procedure: Sham Low-load Blood Flow Restriction training

HL-Et

ACTIVE COMPARATOR

70% of repetition maximum

Procedure: High-load Eccentric training

Interventions

Low-load Blood Flow Restriction training PROCEDURE

Physical therapist will apply the BFR cuffs with 70% of arterial occlusion pressure on the both legs of participants. Then, participants will be asked to perform eccentric trainings (including, double leg squats, split squats, deadlifts, and monster walks) with 30% of repetition maximum.

LL-BFRt

Sham Low-load Blood Flow Restriction training PROCEDURE

Physical therapist will apply the BFR cuffs with 10% of arterial occlusion pressure on the both legs of participants. Then, participants will be asked to perform eccentric trainings (including, double leg squats, split squats, deadlifts, and monster walks) with 30% of repetition maximum.

Sham LL-BFRt

High-load Eccentric training PROCEDURE

Physical therapist will ask participants to perform eccentric trainings (including, double leg squats, split squats, deadlifts, and monster walks) with 70% of repetition maximum.

HL-Et

Eligibility Criteria

• Age: 15 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Being 15-35 years old
• Perform sports level 1 (soccer, basket ball, futsal, combat martial art) at least twice per week.
• Never had an history of ACL injury
• Never had an history of sprain or strain grade III
• Agree to participate until the end of this study period and sign the inform consent

You may not qualify if:

• Having hypertension, blood circulation disease, anemia, obesity, diabetes, kidney failure, vena thromboembolic, cancer, and tumor.
• Disabilities or disabled people.

Sponsors & Collaborators

• Udayana University: lead

Study Sites (1)

Physical therapy laboratory, College of Medicine, Universitas Udayana and ROM Physiotherapy Private Clinic Denpasar

Denpasar, Bali, 80232, Indonesia

Location

Related Publications (1)

• Adhitya IPGS, Aryana IGNW, Kurniawati I, Thanaya SAP, Utama MBR. Effect of Low-Load Blood Flow Restriction Training and High-Load Resistance Training on Quadriceps Strength, Dynamic Stability, and Functional Performance. Clin J Sport Med. 2025 Feb 11. doi: 10.1097/JSM.0000000000001330. Online ahead of print.

  PMID: 39932234 DERIVED

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: July 2, 2023
• First Posted: July 18, 2023
• Study Start: July 17, 2023
• Primary Completion: November 30, 2023
• Study Completion: November 30, 2024
• Last Updated: June 29, 2025

Record last verified: 2025-06

Locations

ID (1)