NCT05949073

Brief Summary

The purpose of this study is to examine the relationship between placing specific retraction cord for different periods of time and the post-operative gingival margin level in humans. Determining the amount of immediate reversible and delayed irreversible gingival recession (vertical gingival retraction) that might happen after placing a retraction cord around a natural tooth in healthy humans. It also aims to investigate the impact of mechanical and chemo-mechanical gingival retraction on periodontal health.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
60

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Jul 2023

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 14, 2023

Completed
1 month until next milestone

First Posted

Study publicly available on registry

July 17, 2023

Completed
8 days until next milestone

Study Start

First participant enrolled

July 25, 2023

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2023

Completed
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2024

Completed
Last Updated

September 6, 2023

Status Verified

September 1, 2023

Enrollment Period

4 months

First QC Date

June 14, 2023

Last Update Submit

September 4, 2023

Conditions

Keywords

retraction cordsgingival recessionperiodontal healthgingival retraction

Outcome Measures

Primary Outcomes (1)

  • The amount of irreversible gingival recession that might happen after gingival retraction.

    The amount of reversible and irreversible gingival recession (vertical gingival retraction) that might occur in healthy humans after placing retraction cords around prepared teeth for different periods of time. This will be measured after recording multiple digital intraoral scans pre-operative, 1 week, and 4 weeks post-operative using Medit i-700 then they will be superimposed using Medit Design tool (previously known as Medit compare) to track the vertical location of the gingival margin.

    4 weeks

Secondary Outcomes (2)

  • The impact of retraction cords on periodontal health.

    4 weeks

  • The level of patient's discomfort.

    Immediately after the intervention

Study Arms (4)

Non impregnated gingival retraction cord - less than 10 minutes

ACTIVE COMPARATOR

Non impregnated gingival retraction cord will be placed around the prepared tooth and left for less than 10 minutes.

Procedure: Non-impregnated retraction cords/ less than 10 minutes

Non impregnated gingival retraction cord - more than 10 minutes

ACTIVE COMPARATOR

Non impregnated gingival retraction cord will be placed around the prepared tooth and left for more than 10 minutes.

Procedure: Non-impregnated retraction cords/ more than 10 minutes

impregnated gingival retraction cord - less than 10 minutes

ACTIVE COMPARATOR

Impregnated gingival retraction cord will be placed around the prepared tooth and left for less than 10 minutes.

Drug: impregnated gingival retraction cord - less than 10 minutes

impregnated gingival retraction cord - more than 10 minutes

ACTIVE COMPARATOR

Impregnated gingival retraction cord will be placed around the prepared tooth and left for more than 10 minutes.

Drug: impregnated gingival retraction cord - more than 10 minutes

Interventions

lower first molar will be prepared for full coverage restoration, plain retraction cord will be placed in the sulcus just before impression recording (less than 10 minutes).

Non impregnated gingival retraction cord - less than 10 minutes

the preparation of the lower first molar for full coverage restoration will be initiated - occlusal reduction, contact points breaking, and preparation with the roughest bur- then a plain retraction cord will be placed and kept in the sulcus until finishing the preparation and impression recording which will take more than 10 minutes.

Non impregnated gingival retraction cord - more than 10 minutes

lower first molar will be prepared for full coverage restoration, Aluminum chloride-impregnated retraction cord will be placed in the sulcus just before impression recording (less than 10 minutes).

Also known as: Aluminum chloride-impregnated retraction cords.
impregnated gingival retraction cord - less than 10 minutes

the preparation of the lower first molar for full coverage restoration will be initiated - occlusal reduction, contact points breaking, and preparation with the roughest bur- then an Aluminum chloride-impregnated retraction cord will be placed and kept in the sulcus until finishing the preparation and impression recording which will take more than 10 minutes.

Also known as: Aluminum chloride-impregnated retraction cord
impregnated gingival retraction cord - more than 10 minutes

Eligibility Criteria

Age18 Years - 50 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Age of 18-50 years
  • Systemically healthy no history of medical disease
  • Volunteers should have a lower first molar indicated for full coverage restoration, of healthy periodontium with an antagonist tooth and proximal contacts.
  • Gingival index score 0,1
  • Plaque index score 0,1
  • Probing depth ≤3 mm
  • No bleeding on probing.

You may not qualify if:

  • Gingival and periodontal disease
  • Pregnancy and lactation
  • History of systemic diseases such as hypertension, diabetes mellitus, HIV, bone metabolic disorders, radiation therapy, and cancer.
  • History of prolonged use of steroids/immunosuppressive agents/aspirin/anticoagulant/other medications.
  • Heavy Smoking.
  • Deleterious habits.
  • Teeth with high scalloped margins, keratinized tissue less than 2 mm, fibrotic gingival tissue, gingival recession, pocket formation deeper than 3mm.
  • Teeth with thick flat gingival phenotype.
  • Teeth with Sub-gingival caries or restoration at the buccal surface.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

the University of Jordan

Amman, Jordan

RECRUITING

Related Publications (5)

  • Al Hamad KQ, Azar WZ, Alwaeli HA, Said KN. A clinical study on the effects of cordless and conventional retraction techniques on the gingival and periodontal health. J Clin Periodontol. 2008 Dec;35(12):1053-8. doi: 10.1111/j.1600-051X.2008.01335.x.

    PMID: 19040582BACKGROUND
  • Ruel J, Schuessler PJ, Malament K, Mori D. Effect of retraction procedures on the periodontium in humans. J Prosthet Dent. 1980 Nov;44(5):508-15. doi: 10.1016/0022-3913(80)90069-4.

    PMID: 7003108BACKGROUND
  • Sarmento HR, Leite FR, Dantas RV, Ogliari FA, Demarco FF, Faot F. A double-blind randomised clinical trial of two techniques for gingival displacement. J Oral Rehabil. 2014 Apr;41(4):306-13. doi: 10.1111/joor.12142. Epub 2014 Jan 22.

    PMID: 24446590BACKGROUND
  • Feng J, Aboyoussef H, Weiner S, Singh S, Jandinski J. The effect of gingival retraction procedures on periodontal indices and crevicular fluid cytokine levels: a pilot study. J Prosthodont. 2006 Mar-Apr;15(2):108-12. doi: 10.1111/j.1532-849X.2006.00083.x.

    PMID: 16650011BACKGROUND
  • Einarsdottir ER, Lang NP, Aspelund T, Pjetursson BE. A multicenter randomized, controlled clinical trial comparing the use of displacement cords, an aluminum chloride paste, and a combination of paste and cords for tissue displacement. J Prosthet Dent. 2018 Jan;119(1):82-88. doi: 10.1016/j.prosdent.2017.03.010. Epub 2017 May 5.

    PMID: 28478985BACKGROUND

MeSH Terms

Conditions

Gingival Recession

Condition Hierarchy (Ancestors)

Gingival DiseasesPeriodontal DiseasesMouth DiseasesStomatognathic DiseasesPeriodontal Atrophy

Study Officials

  • Ahmad Mahmoud, Phd

    University of Jordan

    STUDY DIRECTOR

Central Study Contacts

Majdoleen Fouad, Msc

CONTACT

Mohammad Al-Rabab'ah, Phd

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Postgraduate Student.

Study Record Dates

First Submitted

June 14, 2023

First Posted

July 17, 2023

Study Start

July 25, 2023

Primary Completion

December 1, 2023

Study Completion

May 1, 2024

Last Updated

September 6, 2023

Record last verified: 2023-09

Data Sharing

IPD Sharing
Will not share

Locations