Effect of Low-load Resistance Training vs. High-intensity Interval Training on Local Muscle Endurance

NCT05945641 | Recruiting

• 1 other identifier: H23-01009
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Local muscle endurance (LME) is the ability of a muscle(s) to resist fatigue and is needed for daily activities of life such as climbing stairs, lifting/moving objects, and in sport contexts like rock climbing, mixed martial arts, cross-fit, kayaking and canoeing. Therefore, the investigators want learn how to improve LME and understand what in human bodies changes during exercise training to cause these changes. The investigators know that lifting weights improves muscle strength which is believed to improve LME. Specifically lifting less heavy weights (LLRET) for more repetitions leads to greater gains in LME opposed to heavier weights for fewer repetitions. Therefore, lifting less heavy weights likely causes greater changes in our muscles than lifting heavier weights that cause improvements in LME. Aerobic exercise preformed at high intensities in an interval format (HIIT) may also help improve LME by increasing our muscle's ability to produce energy during exercise. Therefore, the investigators want to see which of LLRET or HIIT leads to greater improvements in LME.

Conditions

Hypertrophy; Muscle Strength; High-Intensity Interval Training; Resistance Training

Keywords

Muscle Strength; Local Muscle Endurance; Muscle Hypertrophy; Mitochondrial Content; Mitochondrial Function; Muscle Capillarization; High-Intensity Interval Training; Sprint Interval Training; Low Load Resistance Training; Resistance Training; Interval Training; Knee Extension; Muscle Endurance

Outcome Measures

Primary Outcomes (4)

• Change in repetitions completed for 30% pre-training 1- Repetition maximum (Single leg Knee extension)

  The number of single leg knee extension repetitions that one can complete at 30% of their pre-training 1-RM

  Change from baseline to 6 weeks

• Change in Repetitions completed for 30% pre-training 1- Repetition maximum (Single leg Knee extension)

  The number of single leg knee extension repetitions that one can complete at 30% of their pre-training 1-RM

  Change from baseline to 12 weeks

• Change in CFPE index (Capillary to fiber ratio normalized to fiber perimeter)

  Mean number of capillaries touching each muscle fibre (normalized to the fibre perimeter). Assessed using imaging of muscle samples gathered via muscle biopsies.

  Change from baseline to 12 weeks

• Change in Maximal Citrate synthase (CS) Activity

  Indicator of Mitochondrial content and function in skeletal muscle.

  Change from baseline to 12 weeks

Secondary Outcomes (17)

• Change in Single leg Knee extension 1- Repetition maximum (weight lifted)

  Change from baseline to 6 weeks

• Change in Single leg Knee extension 1- Repetition maximum (weight lifted)

  Change from baseline to 12 weeks

• Change in Single leg Knee extension Isometric Maximum Voluntary Contraction

  Change from baseline to 6 weeks

• Change in Single leg Knee extension Isometric Maximum Voluntary Contraction

  Change from baseline to 12 weeks

• Change in Single leg Knee Flexion Isometric Maximum Voluntary Contraction

  Change from baseline to 6 weeks

Study Arms (2)

Low Load Resistance Training

EXPERIMENTAL

LLRET - 12 weeks (2-3 times/week) 3 sets of Knee extension exercise (single leg) done at 30%1- RM. Performed to failure with 3 minutes of rest between sets, weight lifted will be adjusted throughout the study to keep repetitions completed in a 20-30 repetition range.

Behavioral: Low Load Resistance training

Sprint/High Intensity Interval Training

EXPERIMENTAL

SIT/HIIT- 12 weeks (2-3 times/week), mix of SIT and HIIT (8-15 sets/session). SIT -30 second Super Maximal "Wingate style intervals" performed on a Kicking ergometer (single leg) with 4 minutes rest provided between sets (number of interval ranges from 4-5), load determined from DEXA leg lean mass and will not be altered throughout training. HIIT - 1-minute Submaximal efforts (90% single leg kicking ergometer VO2Peak Wattage) performed on a kicking ergometer (single leg) with 1 minute rest provided between sets (number of interval ranges from 8-10), if all sets completed wattage will be increased by 5watts for the next training session.

Behavioral: Sprint/High Intensity Interval Training

Interventions

Low Load Resistance training BEHAVIORAL

Performing single leg knee extension exercise with using equivalent to \~30%1-RM to failure,

Also known as: LLRET

Low Load Resistance Training

Sprint/High Intensity Interval Training BEHAVIORAL

Performing repeated submaximal/maximal 30second-60 seconds (1-3 minute rest between) aerobic intervals on a Kicking ergometer (modified bike that allows cycling to be performed with one leg using a kicking motion).

Also known as: SIT/HIIT

Sprint/High Intensity Interval Training

Eligibility Criteria

• Age: 19 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Able to understand and communicate in English
• years of age
• All "No" answers on the CSEP Get Active questionnaire or doctors' approval to participate
• Untrained participants: no structured resistance and/or endurance training over the past 12-months (i.e., \>2 hours per week of structured/periodized training)

You may not qualify if:

• BMI lower than 18 or greater than 30
• Current use of cigarettes or other nicotine devices
• Any major uncontrolled cardiovascular, muscular, metabolic, and/or neurological disorders
• Any medical condition impacting the ability to participate in maximal exercise
• Type one or type two diabetes
• Diagnosis of cancer or undergoing cancer treatment in the past 12 months
• Taking blood-thinning medication or the presence of a bleeding disorder
• Drug therapy with any drugs that alter skeletal muscle metabolism (i.e., Metformin, Benzodiazepines)

Sponsors & Collaborators

• University of British Columbia: lead

Study Sites (1)

Univeristy if British Columbia

Vancouver, British Columbia, V6T 1Z3, Canada

RECRUITING

MeSH Terms

Conditions

Hypertrophy

Interventions

High-Intensity Interval Training

Condition Hierarchy (Ancestors)

Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Central Study Contacts

Lucas A Wiens, BSc

CONTACT

7788377665; wiensl55@student.ubc.ca

Cameron J Mitchell, PhD

CONTACT

604 827 2072; cameron.mitchell@ubc.ca

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Masking Details: Since the interventions are exercise interventions it is not possible to blind either the participants or Investigator to which condition each participants leg receives. However, the legs will be randomly assigned to their conditions (neither the participant nor the Investigator will determine this.)
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Within subject Design: Each participant will have one leg randomly assigned to each training condition. Training for each leg will occur over the same 12 week training period.

Study Record Dates

• First Submitted: June 9, 2023
• First Posted: July 14, 2023
• Study Start: September 27, 2023
• Primary Completion: April 1, 2025
• Study Completion: May 1, 2025
• Last Updated: March 30, 2025

Record last verified: 2024-05

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR
• Time Frame: Data will be made available after publication/completion of the project. Data will remain available for at least 10 years following the completion of this project.
• Access Criteria: Data will only be released to researchers who have valid association with an institution or private laboratory.

Locations

CA (1)