NCT05928013

Brief Summary

A single centre validation/method comparison study of the experimental NERVE device for the measurement of vibration perception threshold against the established 'Neurothesiometer' device, evaluating agreement and reliability. It will also include collecting feedback from patients, carers and clinicians on the usability of the device

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
328

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Apr 2023

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 19, 2023

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

May 25, 2023

Completed
1 month until next milestone

First Posted

Study publicly available on registry

July 3, 2023

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 7, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 7, 2024

Completed
Last Updated

February 21, 2025

Status Verified

February 1, 2025

Enrollment Period

1.1 years

First QC Date

May 25, 2023

Last Update Submit

February 19, 2025

Conditions

Outcome Measures

Primary Outcomes (4)

  • Vibration Perception Threshold (volts) as measured by Health Care Professionals

    Measured using Neurothesiometer and NERVE device

    Baseline

  • Vibration Perception Threshold (volts) as measured by Health Care Professionals

    Measured using Neurothesiometer and NERVE device

    Follow up within baseline visit

  • Vibration Perception Threshold (volts) as measured by person with diabetes

    Measured using NERVE device

    Baseline

  • Vibration Perception Threshold (volts) as measured by person with diabetes

    Measured using NERVE device

    Follow up within baseline visit

Study Arms (1)

Person With Diabetes

EXPERIMENTAL

A health care professional will conduct the vibration perception threshold testing using both the Neurothesiometer and NERVE diagnostic testing on the person with diabetes. The person with diabetes will conduct the vibration perception threshold testing using the NERVE device. There is an option for a carer/buddy to conduct the vibration perception threshold testing with the NERVE device on the person with diabetes.

Diagnostic Test: NeurothesiometerDiagnostic Test: NERVE

Interventions

NeurothesiometerDIAGNOSTIC_TEST

The 'gold standard' device for Vibration Perception Threshold testing

Person With Diabetes
NERVEDIAGNOSTIC_TEST

The experimental device for Vibration Perception Threshold testing developed by the project team

Person With Diabetes

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Formally Diagnosed With Diabetes

You may not qualify if:

  • \. Un- willing or un-able to provide free informed consent (no time limit)
  • \. Un-willing or un-able to comply with all protocol requirements including study assessments;
  • \. Bilateral foot ulcers

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Royal Bournemouth Hospital

Bournemouth, Dorset, BH7 7DW, United Kingdom

Location

MeSH Terms

Conditions

Diabetic Foot

Condition Hierarchy (Ancestors)

Diabetic AngiopathiesVascular DiseasesCardiovascular DiseasesFoot UlcerLeg UlcerSkin UlcerSkin DiseasesSkin and Connective Tissue DiseasesDiabetes ComplicationsDiabetes MellitusEndocrine System DiseasesDiabetic Neuropathies

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
SCREENING
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER GOV
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 25, 2023

First Posted

July 3, 2023

Study Start

April 19, 2023

Primary Completion

May 7, 2024

Study Completion

May 7, 2024

Last Updated

February 21, 2025

Record last verified: 2025-02

Locations