Effects of Training Dose on Computerized Cognitive Training in Patients With Cognitive Impairment

NCT05922319 | Completed

• 1 other identifier: 2023027
• Study Type: observational
• Target: 21,845
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to explore the optimal dose of computerized cognitive training in patients with cognitive impairment. The main questions it aims to answer are:

• Is there an optimal dose of computerized cognitive training for patients with cognitive impairment?
• Is the optimal dose different in patients in different age populations? Participants enrolled in the study took a reported computerized cognitive training program and the training data were analyzed for exploring the optimal dose. The researchers will compare the different dose groups to see if there is an optimal dose for the highest improvement in cognitive abilities. The researchers will additionally compare two age groups (aged younger than 60y or aged 60y and older) to see if the optimal doses in the two groups are different.

Conditions

Cognitive Impairment, Mild; Dementia

Outcome Measures

Primary Outcomes (1)

• Change in cognitive abilities between the adjacent weeks

  Cognitive ability is measured on the final day of training each week. The cognitive ability throughout a week is calculated based on the overall performance of cognitive training. The overall training performance is an averaged performance integrating the performance of all cognitive training tasks targeting different cognitive domains (e.g., thinking, memory, perception, attention, executive function). The performance of a certain training task is standardized according to normative scores from 0 to 100. Change in cognitive abilities is quantified as the disparity of cognitive abilities between the adjacent weeks (the measurement will be executed everyweek repeatedly).

  At the end of each week through the study completion (up to 5 years)

Study Arms (1)

Patients with cognitive impairment taking computerized cognitive training

The exposures and outcomes were measured repeatedly during the training process for each patient. The outcomes were compared to assess the effect of different exposures (computerized cognitive training with different doses). A mixed effects model was built to solve the random effects of patients.

Other: Computerized cognitive training with different training doses

Interventions

Computerized cognitive training with different training doses OTHER

The training dose was defined as training frequency (number of training days per week) and average training duration per training day. The daily dose was divided into 13 categories with an interval of 5 minutes and the training frequency has 7 categories according to the number of training days per week.

Patients with cognitive impairment taking computerized cognitive training

Eligibility Criteria

• Age: 40 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The participants are outpatients who took a reported computerized cognitive training program at home in 2017-2022 in China.

You may qualify if:

• Patients with cognitive impairment.
• Patients who took computerized cognitive training in 2017-2022.
• age ≥ 40 years
• Training duration ≥ 2 weeks

You may not qualify if:

• with moderate to severe dementia, cancer, unstable systemic diseases, or psychiatric diseases

Sponsors & Collaborators

• Xuanwu Hospital, Beijing: lead

Study Sites (1)

Xuanwu Hospital, Capital Medical University

Beijing, 100053, China

Location

MeSH Terms

Conditions

Cognitive Dysfunction; Dementia

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• Yi Tang, M.D., Ph.D.

  Xuanwu Hospital, Beijing

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 2, 2023
• First Posted: June 28, 2023
• Study Start: July 1, 2023
• Primary Completion: August 30, 2023
• Study Completion: August 31, 2023
• Last Updated: May 21, 2024

Record last verified: 2023-06

Locations

CN (1)