Record Voxel Rate Nonlinear Optical Microscope to Unravel Brain Connectome and Signaling-Establish Reliably Electrophysiological Readouts From Human-induced Pluripotent Stem Cells (hiPSCs)-Derived Cerebral Organoids and Surgically Dissected Human Live Brains
1 other identifier
interventional
500
1 country
1
Brief Summary
The research aims to establish a big database of multiple kinds of brain tissues and prove the relevance of human brain tissue models and hiPSCs-derived organoid models.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started May 2023
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2023
CompletedFirst Submitted
Initial submission to the registry
June 18, 2023
CompletedFirst Posted
Study publicly available on registry
June 27, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 31, 2026
August 21, 2024
May 1, 2024
3.7 years
June 18, 2023
August 19, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Acquire neuronal structual (image frame) results of different brain regions
By interpreting the microscopic images of different brain regions' tissues , an attempt is made to understand the structure of brain disease tissues (via cell morphology, microvessels, etc).
3 years
Acquire electrophysiological readout (voltage amplitude, mV) datas of different brain regions
By interpreting the neuron electric reactive datas, an attempt is made to know the neuronal activity (via detecting voltage amplitude change) between multiple neurons.
3 years
Secondary Outcomes (1)
To conduct imaging for multiple types of human brain tissues and construct the neuron image database
3 years
Study Arms (2)
Multiphoton microscopy
EXPERIMENTALElectrophysiological system
EXPERIMENTALInterventions
Electrophysiological system is used for examining voltage variation in biological samples. And multiphoton microscopy is a common type of nonlinear optical microscope.
Multiphoton microscope acquires high-resolution image based on nonlinear optics and can be used for detect biological specimens.
Eligibility Criteria
You may qualify if:
- \. Patients older than the age of 18 with diagnosis of brain disease (both newly-diagnosed or recurrent) who are suitable and willing to receive resection surgery.
You may not qualify if:
- Patients who cannot give consent to participate in the study.
- The tumor samples failed to give a conclusive pathological diagnosis by standard pathological workflow.
- Patients who only receives biopsy surgery rather than resection surgery.
- Significant post-irradiation effect or radiation necrosis reported in the pathological examination.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of Surgery, National Taiwan University Hospital and College of Medicine, National Taiwan University
Taipei, Taiwan
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 18, 2023
First Posted
June 27, 2023
Study Start
May 1, 2023
Primary Completion (Estimated)
December 31, 2026
Study Completion (Estimated)
December 31, 2026
Last Updated
August 21, 2024
Record last verified: 2024-05