Sex-specific Effect of Restricted Sleep on Brain Health

NCT05920759 | Completed

• 1 other identifier: 2097207
• Study Type: interventional
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to compare the impact of restricted sleep on brain blood health in healthy men and women. The main question\[s\] it aims to answer are:

• Whether morning cerebral blood flow velocity is greater following a night of normal sleep compared to restricted sleep
• Whether the effect of sleep restriction on cerebral blood flow will be greater in males compared to females Participants will complete one 1-hour screening visit and two 2.5-hour study visits. Study visits will be conducted on two separate days.

Conditions

Cerebrovascular Circulation

Outcome Measures

Primary Outcomes (1)

• Cerebral blood flow velocity

  Greater morning cerebral blood flow velocity following a night of normal sleep compared to restricted sleep

  Two days

Study Arms (2)

Normal sleep

PLACEBO COMPARATOR

Participants will sleep for 7-9 hours the night prior to the study visit.

Diagnostic Test: Cerebral blood flow

Restricted sleep

EXPERIMENTAL

Participants will restrict sleep to four hours the night prior to the study visit.

Diagnostic Test: Cerebral blood flow

Interventions

Cerebral blood flow DIAGNOSTIC_TEST

Transcranial Doppler (TCD) is a non-invasive diagnostic tool used to estimate cerebral blood flow velocity (CBFV), cerebral autoregulation, cerebrovascular reactivity (CVR), intracranial pressure, cerebral perfusion pressure as well as other indicators of cerebral hemodynamics and autoregulation.

Normal sleep; Restricted sleep

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy adult men and women, 18-45 years of age, BMI 18-30 kg/m2, non-pregnant, non-breastfeeding, and non-nicotine users

You may not qualify if:

• any medications known to affect sleep, autonomic, metabolic, or cardiovascular health, have a self-reported history of hepatic, renal, pulmonary, cardiovascular, or neurological disease, stroke or neurovascular disease, bleeding/clotting disorders, sleep apnea or other sleep disorders, diabetes, history of alcoholism or substance abuse, major cardiovascular event or surgical procedure within the past three months, or hypertension

Sponsors & Collaborators

• University of Missouri-Columbia: lead

Study Sites (1)

University of Missouri

Columbia, Missouri, 65211, United States

Location

MeSH Terms

Interventions

Cerebrovascular Circulation

Intervention Hierarchy (Ancestors)

Blood Circulation; Cardiovascular Physiological Phenomena; Circulatory and Respiratory Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Interim Chair & Associate Professor

Study Record Dates

• First Submitted: June 16, 2023
• First Posted: June 27, 2023
• Study Start: October 1, 2023
• Primary Completion: July 1, 2025
• Study Completion: September 1, 2025
• Last Updated: November 26, 2025

Record last verified: 2025-11

Locations

US (1)