MRI Biomarkers and Exercise

NCT02729428 | Completed

• 4 other identifiers: 2015-1611CVR-AAA4385A176000EDUC/KINESIOLOGY/KINESIO
• Study Type: observational
• Target: 71
• Locations: 1 country
• Sites: 1

Brief Summary

The overall goal of observational study is to examine the age-related and habitual exercise training status-related differences in structural and functional changes in the human brain, detected by magnetic resonance (MR) imaging.

Conditions

Cerebrovascular Circulation

Keywords

Aging; White Matter Hyperintensity Volume; Default Mode Network Connectivity; Cognitive Function; Cardiorespiratory Fitness; Magnetic Resonance Imaging

Outcome Measures

Primary Outcomes (1)

• White Matter Hyperintensity Volume

  Utilize an MRI to measure brain volume when participant is at rest

  60 minutes

Secondary Outcomes (2)

• Default Mode Network Connectivity

  60 minutes

• Middle Cerebral Artery Blood Flow Scan

  60 minutes

Study Arms (4)

Exercise trained young adults

Exercise trained young adults between the age of 18-35 years.

Device: MRI

Sedentary young adults

Sedentary young adults between the age of 18-35 years.

Device: MRI

Exercise trained older adults

Exercise trained older adults between the age of 55-75 years.

Device: MRI

Sedentary older adults

Sedentary older adults between the age of 55-75 years.

Device: MRI

Interventions

MRI DEVICE

Participants will undergo an MRI scan

Exercise trained older adults; Exercise trained young adults; Sedentary older adults; Sedentary young adults

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Subjects for this study will include healthy young adults (18-35 years old), sedentary older adults (55-75 years old), and healthy exercise trained older adults (55-75 years old). Both men and women will be eligible to participate in this study.

You may qualify if:

• Between 18-35 or 55-75
• Body mass index \<34 kg/m2
• Physically active (exercise more than 3 times per week for at least 30 min) or sedentary (no formal exercise over 1 hour per week)

You may not qualify if:

• Current smoker
• History or evidence of: hepatic disease, renal disease, hematological disease, peripheral vascular disease, stroke/neurovascular disease, diabetes, hypertension
• Part of a vulnerable population (e.g. pregnant women, prisoner, individuals lacking capacity to consent, etc.)

Sponsors & Collaborators

• University of Wisconsin, Madison: lead
• National Institutes of Health (NIH): collaborator

Study Sites (1)

Gymnasium-Natatorium

Madison, Wisconsin, 53716, United States

Location

Related Publications (30)

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Study Officials

• Jill N Barnes, PhD

  University of Wisconsin, Madison

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 24, 2016
• First Posted: April 6, 2016
• Study Start: April 1, 2016
• Primary Completion: April 1, 2019
• Study Completion: April 1, 2019
• Last Updated: December 9, 2019

Record last verified: 2019-12

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)