New Biomarkers in Axial Sypondyloarthropathy; SII and SIRI
In Patients With Axial Spondyloarthropathy; Evaluation of the Relationship Between the Systemic Immune Inflammation Index and the Systemic Inflammatory Response Index With Disease Activity and Function
1 other identifier
observational
155
1 country
1
Brief Summary
investigators aimed to evaluate the relationship between Systemic Immune Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) and disease activity in patients with axial spondyloarthropathy (SpA).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Jun 2023
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 10, 2023
CompletedFirst Posted
Study publicly available on registry
June 22, 2023
CompletedStudy Start
First participant enrolled
June 22, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 10, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
August 10, 2023
CompletedAugust 23, 2023
August 1, 2023
18 days
June 10, 2023
August 21, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Comparison of SIRI and SII between Patient and Healthy Control
SIRI= neutrophil count\*monocyte count/lymphocyte count and SII= neutrophil count\*platelet count/lymphocyte count.
Baseline
Secondary Outcomes (1)
Correlation analysis of SIRI and SII with scales and laboratory findings
Baseline
Study Arms (2)
group 1
healthy controls
group 2
axial spondyloarthropathy
Interventions
Complete blood count and erythrocyte sedimentation rate and C-reactive protein values of the participants were analyzed by laboratory test.
Eligibility Criteria
Group 1:healthy controls working in our hospital, Group 2: SpA patients diagnosed according to the 2009 Assessment of Spondyloarthritis International Society classification criteria
You may qualify if:
- SpA patients diagnosed according to the 2009 Assessment of Spondyloarthritis International Society classification criteria
- healthy controls working in our hospital,
You may not qualify if:
- infections, coronary artery disease, kidney and liver dysfunction, cancer diagnosis, surgery in the last three months, diabetes mellitus diagnosis, hypertension and pregnant women
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Istanbul Training and Resarch Hospital
Istanbul, Turkey (Türkiye)
Related Publications (1)
Wu J, Yan L, Chai K. Systemic immune-inflammation index is associated with disease activity in patients with ankylosing spondylitis. J Clin Lab Anal. 2021 Sep;35(9):e23964. doi: 10.1002/jcla.23964. Epub 2021 Aug 21.
PMID: 34418163BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Burak Tayyip DEDE, MD
İstanbul Training and Research Hospital
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER GOV
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Physical Medicine and Rehabilitation
Study Record Dates
First Submitted
June 10, 2023
First Posted
June 22, 2023
Study Start
June 22, 2023
Primary Completion
July 10, 2023
Study Completion
August 10, 2023
Last Updated
August 23, 2023
Record last verified: 2023-08
Data Sharing
- IPD Sharing
- Will not share