Comparison of CT Scan Between Patients With Axial Spondyloarthritis and Control Subjects

NCT05779969 | Completed

• 1 other identifier: CHRD 2222
• Study Type: observational
• Target: 377
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to define structural damage to the manubriosternal joint (MST) in axial spondyloarthritis (axSpA) by comparing its CT scan aspects between a population of patients with radiographic (axSpA) and a control population free of chronic inflammatory rheumatism.

Conditions

Axial Spondyloarthritis

Keywords

Manubriosternal joint,; Axial spondyloarthritis,; Chest CT scan

Outcome Measures

Primary Outcomes (1)

• To define the structural damage of the manubriosternal joint (MST) in axSpA by comparing its Chest CT scan aspects between a population of patients with radiographic axSpA and a control population free of chronic inflammatory rheumatism

  Assessment of the various aspects of the manubriosternal joint on the CT scan. These different elements of analysis are grouped in an evaluation grid. Assessment of the various aspects of the manubriosternal joint on the CT scan. These different elements of analysis are grouped in an evaluation grid. The prevalence of each unit anomaly (e.g. "erosions") will be compared between the radiographic axSpA population and the control population.

  At the end of the study, an average of 1 month

Secondary Outcomes (4)

• Determination of the prevalence of structural damage to the manubriosternal joint (MST) in radiographic axSpA by comparing this population with the control population

  At the end of the study, an average of 1 month

• Determination of the prevalence of structural damage to the manubriosternal joint (MST) in non-radiographic axSpA by comparing this population with the control population

  At the end of the study, an average of 1 month

• Determination of the prevalence of structural damage to the manubriosternal joint (MST) between radiographic axSpA and non- radiographic axSpA

  At the end of the study, an average of 1 month

• Search for a significant association between a phenotypic feature of axSpA and the existence of structural damage to the manubriosternal joint (MST)

  At the end of the study, an average of 1 month

Study Arms (2)

Chest CT scan Patient

Identification of structural damage to the manubriosternal joint (MST) in a population of patients with radiographic axSpA

Other: Chest CT scan

Chest CT scan Control

Identification of structural damage to the manubriosternal joint (MST) in a control population free of chronic inflammatory rheumatism on chest CT.

Other: Chest CT scan

Interventions

Chest CT scan OTHER

Comparison of structural damage to the manubriosternal joint (MST) between a population of patients with radiographic axSpA and a control population free of chronic inflammatory rheumatism on chest CT.

Chest CT scan Control; Chest CT scan Patient

Eligibility Criteria

• Age: 18 Years - 69 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients having a Chest CT scan (as part of a conventional hospitalization or Day hospitalization) between 01/01/2015 and 30/10/2022 for a population of patients with radiographic axSpA and a control population free of chronic inflammatory rheumatism

You may qualify if:

• axSpA population:
• Adults aged 18 to 69 years,
• Diagnosis of axSpA according to the ASAS 2009 criteria,
• Hospitalized in the Rheumatology Department of the NOVO Hospital (Pontoise site) from 01/01/2015 to 30/10/2022 and had a Chest CT scan with images available in the hospital's computer system,
• Informed of the study and did not object.
• Control population:
• Adults aged 18 to 69 years,
• Day hospitalization in the pneumology department of the NOVO Hospital (Pontoise site) from 01/01/2015 to 30/10/2022 and having had a lung scan on this occasion,
• Informed of the study and did not object.

You may not qualify if:

• axSpA population:
• Peripheral spondyloarthritis,
• Unavailability of chest CT scan images in the hospital computer system,
• Unknown result of pelvic X-ray.
• Control population:
• Lung cancer or suspected lung cancer
• Any of the following conditions: spondyloarthritis, rheumatoid arthritis, psoriatic arthritis, SAPHO syndrome, chest wall bone disease, tumour bone disease, severe scoliosis, malformative syndrome
• History of thoracic trauma or thoracic surgery,
• Unavailability of chest CT scan images in the hospital computer system.

Sponsors & Collaborators

• Hôpital NOVO: lead

Study Sites (1)

Rheumatology department - NOVO Hospital - Pontoise site

Pontoise, 95390, France

Location

Related Publications (7)

• Taurog JD, Chhabra A, Colbert RA. Ankylosing Spondylitis and Axial Spondyloarthritis. N Engl J Med. 2016 Jun 30;374(26):2563-74. doi: 10.1056/NEJMra1406182. No abstract available.

  PMID: 27355535 BACKGROUND

• van der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum. 1984 Apr;27(4):361-8. doi: 10.1002/art.1780270401.

  PMID: 6231933 BACKGROUND

• Rudwaleit M, van der Heijde D, Landewe R, Listing J, Akkoc N, Brandt J, Braun J, Chou CT, Collantes-Estevez E, Dougados M, Huang F, Gu J, Khan MA, Kirazli Y, Maksymowych WP, Mielants H, Sorensen IJ, Ozgocmen S, Roussou E, Valle-Onate R, Weber U, Wei J, Sieper J. The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection. Ann Rheum Dis. 2009 Jun;68(6):777-83. doi: 10.1136/ard.2009.108233. Epub 2009 Mar 17.

  PMID: 19297344 BACKGROUND

• Elhai M, Paternotte S, Burki V, Durnez A, Fabreguet I, Koumakis E, Meyer M, Payet J, Roure F, Dougados M, Gossec L. Clinical characteristics of anterior chest wall pain in spondyloarthritis: an analysis of 275 patients. Joint Bone Spine. 2012 Oct;79(5):476-81. doi: 10.1016/j.jbspin.2011.10.003. Epub 2011 Nov 25.

  PMID: 22119315 BACKGROUND

• Wendling D, Prati C, Demattei C, Loeuille D, Richette P, Dougados M. Anterior chest wall pain in recent inflammatory back pain suggestive of spondyloarthritis. data from the DESIR cohort. J Rheumatol. 2013 Jul;40(7):1148-52. doi: 10.3899/jrheum.121460. Epub 2013 May 15.

  PMID: 23678156 BACKGROUND

• Weber U, Lambert RG, Rufibach K, Maksymowych WP, Hodler J, Zejden A, Duewell S, Kissling RO, Filipow PL, Jurik AG. Anterior chest wall inflammation by whole-body magnetic resonance imaging in patients with spondyloarthritis: lack of association between clinical and imaging findings in a cross-sectional study. Arthritis Res Ther. 2012 Jan 6;14(1):R3. doi: 10.1186/ar3551.

  PMID: 22226453 BACKGROUND

• Cameron HU, Fornasier VL. The manubriosternal joint--ananatomicoradiological survey. Thorax. 1974 Jul;29(4):472-4. doi: 10.1136/thx.29.4.472.

  PMID: 4854943 BACKGROUND

MeSH Terms

Conditions

Axial Spondyloarthritis

Condition Hierarchy (Ancestors)

Spondylarthropathies; Spondylarthritis; Spondylitis; Spinal Diseases; Bone Diseases; Musculoskeletal Diseases; Ankylosis; Joint Diseases; Arthritis

Study Officials

• Dr Edouart Pertuiset

  Hospital NOVO - Pontoise site

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 7, 2023
• First Posted: March 22, 2023
• Study Start: February 9, 2023
• Primary Completion: December 13, 2024
• Study Completion: December 13, 2024
• Last Updated: December 31, 2024

Record last verified: 2024-12

Locations

FR (1)