Spoken Discourse Biomarker of PD Cognitive Impairment

NCT05909163 | Completed

• 1 other identifier: STU00209602
• Study Type: observational
• Target: 140
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to identify unique profiles of speech and language changes that distinguish individuals with Parkinson's disease from adults without Parkinson's disease and individuals with Parkinson's disease with cognitive (e.g., memory, thinking skills) impairment from those without cognitive impairment.

Conditions

Parkinson Disease

Outcome Measures

Primary Outcomes (1)

• Discourse Composite Variable

  Weighted variable comprised of discourse features extracted from spoken discourse samples across productivity, lexical retrieval, verbal fluency, syntax complexity, grammatical accuracy, narrative coherence, correct information units, and main event accuracy. Raw data from each measure are multiplied by a specified weight and summed to generate a single composite discourse score.

  baseline

Secondary Outcomes (13)

• Words per minute

  baseline

• Correct information units (CIUs)

  baseline

• % CIUs

  baseline

• CIUs/min

  baseline

• % Main Events

  baseline

Other Outcomes (2)

• Discourse Global Coherence

  baseline

• Discourse Local Coherence

  baseline

Study Arms (2)

Pakinson's disease without cognitive impairment

* Age 50-90 years * Diagnosis of idiopathic Parkinson's disease (UK Brain Bank criteria) made by a movement disorders specialist * Under the care of a movement disorders specialist for a minimum of 1-year duration * Native monolingual English speaker * Hoehn \& Yahr score between 1.5 and 4 * Grade 10 education, or higher * Sufficient vision and hearing (aided or unaided) for all experiment tasks * Montreal Cognitive Assessment (or MoCA-converted MMSE score) greater than or equal to 25 * No subjective complaints of cognitive difficulty or word finding issues

Pakinson's disease with cognitive impairment

* Age 50-90 years * Diagnosis of idiopathic Parkinson's disease (UK Brain Bank criteria) made by a movement disorders specialist * Under the care of a movement disorders specialist for a minimum of 1-year duration * Native monolingual English speaker * Hoehn \& Yahr score between 1.5 and 4 * Grade 10 education, or higher * Sufficient vision and hearing (aided or unaided) for all experiment tasks * Montreal Cognitive Assessment (or MoCA-converted MMSE score) greater than or equal to 17 * Subjective complaints of cognitive difficulty or word finding issues, without significant impact on activities of daily living

Eligibility Criteria

• Age: 50 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Only individuals with PD will be newly recruited and enrolled as part of the study. Healthy adult data will be extracted from extant databases (publicly available) from NIH-funded studies.

You may qualify if:

• Only individuals with PD will be newly recruited and enrolled as part of the study. Healthy adult data will be extracted from extant databases (publicly available) from NIH-funded studies.
• Age 50-90 years
• Diagnosis of idiopathic Parkinson's disease (UK Brain Bank criteria) made by a movement disorders specialist
• Under the care of a movement disorders specialist for a minimum of 1-year duration
• Native monolingual English speaker
• Hoehn \& Yahr score between 1.5 and 4
• Grade 10 education, or higher
• Sufficient vision and hearing (aided or unaided) for all experiment tasks
• Montreal Cognitive Assessment (or MoCA-converted MMSE score) greater than or equal to 25
• No subjective complaints of cognitive difficulty or word finding issues
• Age 50-90 years
• Diagnosis of idiopathic Parkinson's disease (UK Brain Bank criteria) made by a movement disorders specialist
• Under the care of a movement disorders specialist for a minimum of 1-year duration
• Native monolingual English speaker
• Hoehn \& Yahr score between 1.5 and 4

You may not qualify if:

• History of unmanaged or untreated depression or major psychiatric illness
• History of deep brain stimulation surgery (DBS)
• Diagnosis of Dementia with Lewy Bodies

Sponsors & Collaborators

• Northwestern University: lead

Study Sites (1)

Northwestern University

Evanston, Illinois, 60201, United States

Location

Related Publications (10)

• Nicholas LE, Brookshire RH. A system for quantifying the informativeness and efficiency of the connected speech of adults with aphasia. J Speech Hear Res. 1993 Apr;36(2):338-50. doi: 10.1044/jshr.3602.338.

  PMID: 8487525 BACKGROUND

• Brookshire RH, Nicholas LE. Speech sample size and test-retest stability of connected speech measures for adults with aphasia. J Speech Hear Res. 1994 Apr;37(2):399-407. doi: 10.1044/jshr.3702.399.

  PMID: 8028321 BACKGROUND

• Capilouto G, Wright HH, Wagovich SA. CIU and main event analyses of the structured discourse of older and younger adults. J Commun Disord. 2005 Nov-Dec;38(6):431-44. doi: 10.1016/j.jcomdis.2005.03.005. Epub 2005 Apr 26.

  PMID: 16199238 BACKGROUND

• Roberts A, Post D. Information Content and Efficiency in the Spoken Discourse of Individuals With Parkinson's Disease. J Speech Lang Hear Res. 2018 Sep 19;61(9):2259-2274. doi: 10.1044/2018_JSLHR-L-17-0338.

  PMID: 30208482 BACKGROUND

• Thompson CK, Cho S, Hsu CJ, Wieneke C, Rademaker A, Weitner BB, Mesulam MM, Weintraub S. Dissociations Between Fluency And Agrammatism In Primary Progressive Aphasia. Aphasiology. 2012;26(1):20-43. doi: 10.1080/02687038.2011.584691.

  PMID: 22199417 BACKGROUND

• Thompson, C. K., Shapiro, L. P., Li, L., & Schendel, L. (1995). Analysis of verbs and verb-argument structure: A method for quantification of aphasic language production. Clinical Aphasiology, 23, 121-140.

  BACKGROUND

• Harris Wright, H., Koutsoftas, A., Fergadiotis, G., & Capilouto, G. (2010). Coherence in Stories Told by Adults With Aphasia.

  BACKGROUND

• Wright HH, Capilouto GJ. Considering a multi-level approach to understanding maintenance of global coherence in adults with aphasia. Aphasiology. 2012 Jan 1;26(5):656-672. doi: 10.1080/02687038.2012.676855. Epub 2012 May 10.

  PMID: 22962509 BACKGROUND

• Glosser G, Deser T. Patterns of discourse production among neurological patients with fluent language disorders. Brain Lang. 1991 Jan;40(1):67-88. doi: 10.1016/0093-934x(91)90117-j.

  PMID: 2009448 BACKGROUND

• Van Leer E, Turkstra L. The effect of elicitation task on discourse coherence and cohesion in adolescents with brain injury. J Commun Disord. 1999 Sep-Oct;32(5):327-48; quiz 348-9. doi: 10.1016/s0021-9924(99)00008-8.

  PMID: 10498013 BACKGROUND

Related Links

• SALT Subordination index

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: October 21, 2021
• First Posted: June 18, 2023
• Study Start: March 5, 2019
• Primary Completion: February 15, 2023
• Study Completion: February 15, 2023
• Last Updated: June 18, 2023

Record last verified: 2023-06

Locations

US (1)