Machine Vision Based MDS-UPDRS III Machine Rating
Machine Vision Based Machine Rating of MDS-UPDRS III
1 other identifier
observational
871
1 country
8
Brief Summary
The Movement Disorders Society (MDS) Unified Parkinson's Disease Rating Scale (UPDRS) Part III (MDS-UPDRS III) is the primary assessment method for motor symptoms in Parkinson's disease patients. Currently, movement disorder specialists conduct semi-quantitative scoring, which entails limitations such as subjectivity, weak sensitivity, and a limited number of professional physicians. This study, based on machine vision, establishes gold standard labels according to expert scoring. By using machine learning, we develop a machine rating model and compare the model's performance with gold standard rating and general clinical rating to investigate the accuracy of machine vision-based MDS-UPDRS III machine rating.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Mar 2023
8 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2023
CompletedFirst Submitted
Initial submission to the registry
June 7, 2023
CompletedFirst Posted
Study publicly available on registry
June 18, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2024
CompletedJune 18, 2023
March 1, 2023
1.1 years
June 7, 2023
June 7, 2023
Conditions
Outcome Measures
Primary Outcomes (4)
ACC0 of machine rating vs gold standard rating
The accuracy rate when machine rating equals gold standard rating.
1 day
ACC1 of machine rating vs gold standard rating
The accuracy rate when machine rating equals the range of gold standard rating plus or minus one.
1 day
Weighted kappa of machine rating vs gold standard rating
The weighted kappa when machine rating equals gold standard rating.
1 day
Lin's CCC of machine rating vs gold standard rating
The Lin's Concordance Correlation Coefficient when machine rating equals gold standard rating.
1 day
Secondary Outcomes (2)
Accuracy rate of machine rating vs general clinical rating
1 day
Accuracy rate of machine facilitated rating vs general clinical rating
1 day
Interventions
Patients' performance of MDS-UPDRS III will be recorded.
Eligibility Criteria
In this study, participants are mainly recruited from the Department of Neurology at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, as well as from movement disorder clinics at 7 other centers. Participants are enrolled through outpatient assessment and screening. Two specialists in movement disorders independently diagnosed participants as having "Parkinsonism". In cases where there is a diagnostic disagreement, the Movement Disorder Specialist Group at the Department of Neurology, Ruijin Hospital collectively discusses and makes the decision.
You may qualify if:
- Meeting the diagnostic criteria for Parkinsonism established by the International Movement Disorder Society: having bradykinesia, and meeting at least one of the two criteria for resting tremor or muscle rigidity
- to 80 years old
- Good compliance, voluntarily joining the study, and able to sign an informed consent form or have it signed by a legal representative
You may not qualify if:
- Significant cognitive impairment (MMSE ≤ 23)
- Unable to sign written informed consent or unable to complete the trial due to other reasons
- Other situations in which the researcher deems the participant unsuitable for this study
- Participation in other clinical trials
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Ruijin Hospitallead
- Second Affiliated Hospital of Soochow Universitycollaborator
- Beijing Hospitalcollaborator
- Beijing Tiantan Hospitalcollaborator
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technologycollaborator
- Fujian Medical University Union Hospitalcollaborator
- Guangdong Provincial People's Hospitalcollaborator
- West China Hospitalcollaborator
Study Sites (8)
Center for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University
Beijing, Beijing Municipality, 100050, China
Beijing Hospital, Neurology Department
Beijing, Beijing Municipality, 100730, China
Department of Neurology, Fujian Medical University Union Hospital
Fuzhou, Fujian, 350001, China
Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences
Guangzhou, Guangdong, 510080, China
Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, 430022, China
Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University
Suzhou, Jiangsu, 215004, China
Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, 200025, China
Department of Neurology, West China Hospital, Sichuan University
Chengdu, Sichuan, 610044, China
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 7, 2023
First Posted
June 18, 2023
Study Start
March 1, 2023
Primary Completion
April 1, 2024
Study Completion
April 1, 2024
Last Updated
June 18, 2023
Record last verified: 2023-03
Data Sharing
- IPD Sharing
- Will not share