Application of Sticky Bone and Bio-Oss Collagen in Alveolar Ridge Preservation

NCT05902689 | Completed DMC

• 1 other identifier: 2023-0369
• Study Type: interventional
• Target: 42
• Locations: 1 country
• Sites: 1

Brief Summary

In this experiment, after non-traumatic tooth extraction, the blank group underwent natural healing, and the Bio-Oss Collagen underwent alveolar ridge preservation using Bio-Oss Collagen and the Sticky Bone group using Sticky Bone, to verify the application of Bio-Oss Collagen and Sticky Bone in alveolar ridge preservation

Conditions

Alveolar Bone Resorption

Keywords

alveolar ridge preservation; Bio-OSS Collagen; sticky bone

Outcome Measures

Primary Outcomes (1)

• Changes in horizontal ridge widths

  Changes in horizontal ridge widths at 1, 3, and 5 mm below the ridge crest

  baseline (before the surgery) and six months

Secondary Outcomes (8)

• Changes in the vertical heights of the ridge

  baseline (before the surgery) and six months

• Thicknesses of the keratinized gingiva

  baseline (before the surgery) and six months

• width of the keratinized gingiva

  baseline (before the surgery) and six months

• percentages of newly formed bone

  six months

• The percentage of residual materials

  six months postoperative

Study Arms (3)

blank group

NO INTERVENTION

After non-traumatic tooth extraction, the control group will undergo natural healing.

Bio-Oss Collagen group

EXPERIMENTAL

After non-traumatic tooth extraction, the Bio-Oss Collagen group will use alveolar ridge preservation with bio-oss collagen

Procedure: alveolar ridge preservation with bio-oss collagen

Sticky Bone group

EXPERIMENTAL

After non-traumatic tooth extraction, the Sticky Bone group will use Sticky Bone for alveolar ridge preservation

Procedure: alveolar ridge preservation with sticky bone

Interventions

alveolar ridge preservation with sticky bone PROCEDURE

Alveolar ridge preservation with sticky bone is a surgical method that reduces or limits the physiological resorption of alveolar bone after tooth extraction by implanting sticky bone in the socket and covering the biological barrier membrane.

Sticky Bone group

alveolar ridge preservation with bio-oss collagen PROCEDURE

Alveolar ridge preservation with bio-oss collagen is a surgical method that reduces or limits the physiological resorption of alveolar bone after tooth extraction by implanting bio-oss collagen in the socket and covering the biological barrier membrane.

Bio-Oss Collagen group

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• The presence of one adjacent tooth at the extraction site
• Adequate oral hygiene (plaque index \<20%;bleeding on probing \<25% )
• Need for tooth extraction due to endodontic，periapical or periodontal disease.
• Presence of ≥ 2 mm of keratinized tissue
• the extraction sockets have no more than 50% of buccal alveolar bone loss(Integrity of alveolar bone walls)

You may not qualify if:

• Pregnancy or lactation
• Smoking more than 10 cigarettes per day
• with no evidence of acute infection such as severe swelling, suppuration at the extraction site
• Uncontrolled periodontal disease
• Existence of bone metabolic disease
• history of malignancy, radiotherapy, or chemotherapy in the past 5 years
• Administration of bisphosphonates
• long-term use of NSAIDs
• Alcohol or drug abuse
• Infectious disease, such as hepatitis or human immunodeficiency virus (HIV) and/or acquired immunodeficiency syndrome (AIDS)
• Uncontrolled severe diabetes.( hemoglobin A1c \>6.7%)

Sponsors & Collaborators

• Second Affiliated Hospital, School of Medicine, Zhejiang University: lead

Study Sites (1)

2nd Affiliated Hospital, School of Medicine, Zhejiang University, China

Hangzhou, Zhejiang, China

Location

Study Officials

• Li Li Zhou, doctor

  2nd Affiliated Hospital, School of Medicine, Zhejiang University, China

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: The control group underwent natural healing, and the experimental group underwent alveolar ridge preservation using Bio-Oss Collagen and Sticky Bone, respectively.

Study Record Dates

• First Submitted: June 1, 2023
• First Posted: June 15, 2023
• Study Start: June 15, 2023
• Primary Completion: August 15, 2025
• Study Completion: September 15, 2025
• Last Updated: April 13, 2026

Record last verified: 2025-03

Locations

CN (1)