Portal Vein Occlusion is a Valuable Predictor for Postoperative Nausea and Vomiting

NCT05894408 | Completed

• 1 other identifier: SHDC22020204
• Study Type: observational
• Target: 380
• Locations: 1 country
• Sites: 1

Brief Summary

Postoperative nausea and vomiting (PONV) is one of the most common and distressing postoperative complications. PONV risk assessment is recommanded to determine the number of medications or strategies for prophylaxis. Many well-known risk factors have been determined. However, no study has explored liver surgery-specific risk factors. This study aims to identify whether there was an association between portal vein occlusion and PONV among patients after liver surgery. Patients diagnosed with liver cancer and undergoing hepatectomy will be prospectively consecutively recruited. All enrolled patients receive PONV assessments within the first 24 postoperative hours. Logistic regression models will be used to investigate the effects of portal vein occlusion and the other variables on the occurrence of PONV in both univariate and multivariate analyses

Conditions

Postoperative Nausea and Vomiting

Outcome Measures

Primary Outcomes (1)

• Postoperative nausea and vomiting

  PONV will be evaluated on a four-grade scale from 0 (no nausea and no vomiting), 1 (having nausea but no vomiting), 2 (having vomiting without stomach contents ) to 3 (having vomiting with stomach contents).

  up to 24 hours

Study Arms (2)

patients with portal vein occlusion

Other: this is no intervention

patients without portal vein occlusion

Other: this is no intervention

Interventions

this is no intervention OTHER

this is no intervention

patients with portal vein occlusion; patients without portal vein occlusion

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who are diagnosed with liver cancer and underwent hepatectomy are eligible.

You may qualify if:

• older than 18 years, planned admissions and elective surgery, and staying at least 24 hours in the surgical unit

You may not qualify if:

• patients with cognitive impairment and patients who have nausea and vomiting related to other existing diseases, such as gastroesophageal reflux disease.

Sponsors & Collaborators

• Shanghai Zhongshan Hospital: lead

Study Sites (1)

Fudan University Fudan University

Shanghai, Shanghai Municipality, 200032, China

Location

Related Publications (1)

• Chen X, Zhao WJ, Yu J, Zhou H, Shi Y, Gao J, Zhang Y. Duration of hepatic portal occlusion is a valuable predictor for postoperative nausea and vomiting in patients underwent liver resection for liver cancer. BMC Cancer. 2025 Jul 16;25(1):1177. doi: 10.1186/s12885-025-14592-0.

  PMID: 40670918 DERIVED

MeSH Terms

Conditions

Postoperative Nausea and Vomiting

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Nausea; Signs and Symptoms, Digestive; Signs and Symptoms; Vomiting

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 30, 2023
• First Posted: June 8, 2023
• Study Start: June 15, 2023
• Primary Completion: August 1, 2023
• Study Completion: August 1, 2023
• Last Updated: April 8, 2024

Record last verified: 2024-04

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)