Timing of Resistance Exercise in Type 1 Diabetes

NCT05884814 | Unknown

• 1 other identifier: RA HM-2023-009
• Study Type: interventional
• Target: 54
• Locations: 1 country
• Sites: 1

Brief Summary

The aims of the current study are

1. 1.to compare the effects of acute morning and afternoon resistance exercise on blood glucose levels in people with type 1 diabetes.
2. 2.to compare the effects of morning and afternoon resistance exercise training on cardiometabolic health outcomes in people with type 1 diabetes

Conditions

Type 1 Diabetes

Keywords

exercise; circadian rhythm; glucose control; muscle; strength

Outcome Measures

Primary Outcomes (2)

• Change in muscle strength

  Sum of one repetition maximum for the 7 resistance exercise

  Change from baseline to 12 weeks

• Change in interstitial glucose time in range

  Interstitial glucose time in range (3.9-10mmol/L) measured via continuous glucose monitoring

  Change from 6 hours before (baseline) to 6 hours after (post-exercise) an exercise training session

Secondary Outcomes (8)

• Change in appendicular skeletal muscle mass

  Change from baseline to 12 weeks

• Change in whole body fat mass

  Change from baseline to 12 weeks

• Change in physical function

  Change from baseline to 12 weeks

• Change in HbA1c

  Change from baseline to 12 weeks

• Change in interstitial glucose average

  Change from 6 hours before (baseline) to 6 hours after (post-exercise) an exercise training session

Study Arms (3)

Control

PLACEBO COMPARATOR

Habitual physical activity

Behavioral: Habitual physical activity levels

Morning exercise

ACTIVE COMPARATOR

Exercise training between 6-10am

Behavioral: Morning exercise

Afternoon exercise

ACTIVE COMPARATOR

Exercise training between 4-8pm

Behavioral: Afternoon exercise

Interventions

Morning exercise BEHAVIORAL

Between 6-10am participants will attend the gym and perform 10 min of warm up exercise, 3 sets of 7 resistance exercises ( leg press, calf press, leg curl, chest press, lateral raise, seated row and plank)

Morning exercise

Afternoon exercise BEHAVIORAL

Between 4-8pm participants will attend the gym and perform 10 min of warm up exercise, 3 sets of 7 resistance exercises ( leg press, calf press, leg curl, chest press, lateral raise, seated row and plank)

Afternoon exercise

Habitual physical activity levels BEHAVIORAL

Participants will be asked to maintain their normal activity levels

Control

Eligibility Criteria

• Age: 21 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Physician confirmed type 1 diabetes for at least 1 year
• Stable insulin therapy for 3 months prior to the study

You may not qualify if:

• BMI of 45 or higher
• BP of 160/100mmHg or higher
• autonomic neuropathy
• severe proliferative retinopathy
• joint or limb injuries preventing weight-bearing activity
• autonomic neuropathy
• severe proliferative retinopathy
• any other medical condition that prevents participants from exercising safely.

Sponsors & Collaborators

• Dasman Diabetes Institute: lead

Study Sites (1)

Dasman Diabetes Institute

Kuwait City, 15462, Kuwait

RECRUITING

MeSH Terms

Conditions

Diabetes Mellitus, Type 1; Motor Activity

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Autoimmune Diseases; Immune System Diseases; Behavior

Central Study Contacts

Ebaa AlOzairi, MBChB

CONTACT

+965 22242999; ebaa.alozairi@dasmaninstitute.rog

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Chief Medical Officer

Model Details: 1:1:1 parallel group design

Study Record Dates

• First Submitted: May 10, 2023
• First Posted: June 1, 2023
• Study Start: July 1, 2023
• Primary Completion: December 31, 2024
• Study Completion: December 31, 2024
• Last Updated: July 28, 2023

Record last verified: 2023-07

Data Sharing

• IPD Sharing: Will not share

Locations

KU (1)