Effects of Resistance Exercise on Blood Glucose in Post-menopausal Women With Type 1 Diabetes

NCT05203640 | Recruiting

• 1 other identifier: Pro00112972
• Study Type: interventional
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

Regular physical activity has substantial health benefits in people with type 1 diabetes. The fear of hypoglycemia, both during and after exercise, is a major barrier to exercise in this population. A major obstacle to providing specific physical activity and exercise advice is that there are still significant gaps in the fundamental understanding of the impact of physical activity and exercise on blood glucose levels in type 1 diabetes. Women with type 1 diabetes have a substantial increase in cardiovascular risk once they have passed menopause. They may lose both bone quality and muscle mass at a faster rate with aging than those without diabetes. Overall, these changes greatly increase the risk of both cardiovascular and frailty related complications. Despite the many potential benefits of resistance exercise for post-menopausal women with type 1 diabetes, there are currently no published studies examining the effects of resistance exercise in this population. Before being able to design a clinical trial of resistance exercise, an examination of the acute effects of resistance exercise on blood glucose levels in post-menopausal women with type 1 diabetes is required. The present study will compare the glycemic effects of a low resistance, high repetition (3 sets of 15 to 20 repetitions) weight lifting program to the effects of a moderate resistance, moderate repetition (3 sets of 8 to 10 repetitions). The investigators hypothesize that the high repetition program will be associated with a bigger decline in blood glucose during exercise, but that the moderate resistance program will be associated with a higher risk of post-exercise hypoglycemia.

Conditions

Type 1 Diabetes

Keywords

resistance exercise

Outcome Measures

Primary Outcomes (1)

• Blood glucose

  Change in blood glucose during and after exercise

  from 0 minutes to 45 minutes, and from 45 minutes to 105 minutes

Secondary Outcomes (9)

• Mean continuous glucose monitoring (CGM) glucose

  0 to 6 hours post exercise, overnight post exercise (midnight to 6 am) and 24 hours post exercise

• coefficient of variation (CV)

  0 to 6 hours post exercise, overnight post exercise (midnight to 6 am) and 24 hours post exercise

• standard deviation (SD)

  0 to 6 hours post exercise, overnight post exercise (midnight to 6 am) and 24 hours post exercise

• frequency of hypoglycemia

  0 to 6 hours post exercise, overnight post exercise (midnight to 6 am) and 24 hours post exercise

• frequency of hyperglycemia

  0 to 6 hours post exercise, overnight post exercise (midnight to 6 am) and 24 hours post exercise

Study Arms (1)

All participants

EXPERIMENTAL

All participants will be in a single arm that undergoes two separate interventions. These interventions will include a high repetition, low resistance protocol, and a moderate repetition, moderate intensity protocol.

Behavioral: High repetition (HI); Behavioral: Moderate repetition (MOD)

Interventions

High repetition (HI) BEHAVIORAL

Participants will perform 15 to 20 repetitions of 7 different exercises at 50% of their one repetition maximum

All participants

Moderate repetition (MOD) BEHAVIORAL

Participants will perform 8 to 10 repetitions of 7 different exercise at 75-80% of their one repetition maximum

All participants

Eligibility Criteria

• Age: 45 Years - 75 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• female
• type 1 diabetes diagnosed for at least 1 year
• at least 12 months since last menstrual period
• physically able and willing to perform resistance exercise
• HbA1c \< 10%
• residing near Edmonton, Alberta / able to attend laboratory based sessions at the University of Alberta

You may not qualify if:

• Individuals with HbA1c \>9.9%
• Frequent and unpredictable hypoglycaemia
• A change in insulin management strategy within two months of the study
• Blood pressure \> 144/95,
• Severe peripheral neuropathy,
• A history of cardiovascular disease
• Musculoskeletal injuries affecting the ability to perform resistance exercise.
• Individuals who are treated with medications (other than insulin) that affect glucose metabolism (e.g. atypical antipsychotics, corticosteroids)
• A body mass index \>30kg/m2,
• Smoking
• Moderate to high alcohol intake (\>2 drinks per day)

Sponsors & Collaborators

• University of Alberta: lead

Study Sites (1)

Alberta Diabetes Institute

Edmonton, Alberta, T6G 2R3, Canada

RECRUITING

MeSH Terms

Conditions

Diabetes Mellitus, Type 1

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Autoimmune Diseases; Immune System Diseases

Central Study Contacts

Jane Yardley, PhD

CONTACT

780-679-1688; jane.yardley@ualberta.ca

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 10, 2022
• First Posted: January 24, 2022
• Study Start: April 1, 2022
• Primary Completion (Estimated): June 30, 2026
• Study Completion (Estimated): September 1, 2026
• Last Updated: July 8, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)