Obsessions and Suicidality in Youth With Bipolar 1 Disorder

NCT05878808 | Completed

• 1 other identifier: MS-545- 2021
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Obsessive-compulsive disorder (OCD) is a common co-morbidity with bipolar I disorder, a comorbidity that is known to increase suicide risk. This study aimed to assess the presence of OCD in youth diagnosed with bipolar I disorder \& to evaluate the association between OCD and suicide in the same cohort. Eighty subjects diagnosed with bipolar I disorder were enrolled in this study, subjects were divided according to the presence or absence of OCD to Group A: Bipolar disorder patients with OCD (n = 26), Group B: Bipolar disorder patients without OCD (n = 54). The following scales were applied: Dimensional Yale-Brown obsessive compulsive scale (DYBOCS)- Beck scale for Suicidal ideations (BSSI) - Hamilton depression rating scale (HDRS) and Young mania rating scale (YMRS). The results revealed that DYBOCS score of group A was 30.23±0.43, \& of group B was 18.50±1.88 with a significant difference (p\<0.01). There was a significantpositive correlation between BSSI and age, age of onset and YMRS in Group A (p\<0.01). The study demonstrated that OCD is a common comorbidity in youth with bipolar I disorder and may be associated with a greater risk of suicide than in youth with bipolar I disorder without co-morbid OCD. Furthermore, co-morbidity of OCD with bipolar I disorder in youth may be associated with younger age of onset and more severe symptoms profile.

Conditions

Obsessions; Suicide; Bipolar I Disorder; Obsessive-Compulsive Disorder

Keywords

BSSI; DYBOCS; Bipolar disorder

Outcome Measures

Primary Outcomes (1)

• Association of OCD with bipolar I disorder

  1 year

Study Arms (2)

Cases with ocd

Diagnostic Test: Psychometric assessment

Cases without ocd

Diagnostic Test: Psychometric assessment

Interventions

Psychometric assessment DIAGNOSTIC_TEST

Eighty subjects diagnosed with bipolar I disorder were enrolled in this study, subjects were divided according to the presence or absence of OCD to Group A: Bipolar disorder patients with OCD (n = 26), Group B: Bipolar disorder patients without OCD (n = 54). The following scales were applied: Dimensional Yale-Brown obsessive compulsive scale (DYBOCS)- Beck scale for Suicidal ideations (BSSI) - Hamilton depression rating scale (HDRS) and Young mania rating scale (YMRS).

Cases with ocd; Cases without ocd

Eligibility Criteria

• Age: 15 Years - 24 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Eighty subjects diagnosed with bipolar I disorder were enrolled in this study, subjects were divided according to the presence or absence of OCD to Group A: Bipolar disorder patients with OCD (n = 26), Group B: Bipolar disorder patients without OCD (n = 54).

You may qualify if:

• \- Can read and write, agreed to sign the consent, diagnosed with bipolar I disorder

You may not qualify if:

• refused to sign the consent, active manic phase, recent substance use

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Cairo University

Cairo, Egypt

Location

MeSH Terms

Conditions

Obsessive Behavior; Suicide; Obsessive-Compulsive Disorder; Bipolar Disorder

Condition Hierarchy (Ancestors)

Behavioral Symptoms; Behavior; Self-Injurious Behavior; Anxiety Disorders; Mental Disorders; Bipolar and Related Disorders; Mood Disorders

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assist professor

Study Record Dates

• First Submitted: May 18, 2023
• First Posted: May 26, 2023
• Study Start: February 1, 2022
• Primary Completion: September 15, 2022
• Study Completion: January 5, 2023
• Last Updated: May 26, 2023

Record last verified: 2023-05

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)