Articulatory Adaptation Following Oral Cancer Treatment

NCT05876247 | Unknown

• 1 other identifier: METc 2021/711
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 2

Brief Summary

The goal of this longitudinal study is to learn more about the articulatory consequences of surgical oral cancer treatment. The main aims are to study the coordination and development of speech articulation of patients who will undergo surgical treatment for oral cancer longitudinally and whether individual differences in the reliance on auditory or tactile information can predict the success of speech compensatory strategies. Participants will perform multiple speech tasks while motion tracking sensors track the articulatory gestures.

Conditions

Oral Cavity Squamous Cell Carcinoma; Speech Disorders

Keywords

Articulation

Outcome Measures

Primary Outcomes (2)

• Articulatory gestures

  Articulatory movements in three dimensions of the tongue, lips and jaw as measured by the NDI Vox Electromagnetic Articulograph. Measures include: articulator speed (mm/s), total displacement (mm), coordinates (x,y,z) during specific gestures.

  2022-2025

• Acoustic outcomes

  Speech acoustics will be measured in Praat and include the first and second formants of vowels (in Hz), global movement size in terms of acoustic working space (Hz-squared), and the centre of gravity of sibilants (in Hz)

  2022-2025

Study Arms (2)

Individuals treated for oral cancer

Dutch native speakers (18+) who will undergo surgical treatment for a T1 or T2 tumour on the tongue.

Other: Electromagnetic Articulography

Control speakers

Dutch native speakers (18+) without self-reported speech problems.

Other: Electromagnetic Articulography

Interventions

Electromagnetic Articulography OTHER

Motion tracking sensors will track articulatory movements of the tongue, jaw and lips

Control speakers; Individuals treated for oral cancer

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults with and without oral cancer who speak Dutch as their native language

You may qualify if:

• Diagnosed with T1 or T2 tumor in the oral cavity
• At least 18 years old and able to provide informed consent
• Native speaker of Dutch
• Has nog been treated for oral cancer before

You may not qualify if:

• a. Recurrence of disease (for patients)
• b. Treated for oral cancer (for healthy controls) 2. Speech problems (e.g., stuttering) 3. Problems with sight or hearing that impede reading or understanding instructions. When glasses or a hearing aid resolve these problems, then participants are not excluded.
• \. Neurological or psychological disorders (e.g., stroke) 5. Non-removable metal in, on or around the head (piercings, braces, pacemaker, electrodes) 6. Self-reported signs of depression

Sponsors & Collaborators

• University Medical Center Groningen: lead

Study Sites (2)

Faculty of Arts, University of Groningen

Groningen, 9712 EK, Netherlands

RECRUITING

University Medical Centre Groningen

Groningen, 9713 GZ, Netherlands

RECRUITING

MeSH Terms

Conditions

Squamous Cell Carcinoma of Head and Neck; Speech Disorders

Condition Hierarchy (Ancestors)

Carcinoma, Squamous Cell; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Head and Neck Neoplasms; Neoplasms by Site; Language Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Max Witjes, PhD

  University of Groningen

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Thomas Tienkamp, MA

CONTACT

+31 50 36 37051; t.b.tienkamp@umcg.nl

Max Witjes, PhD

CONTACT

+31 (0)50 361 3841; m.j.h.witjes@umcg.nl

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 16, 2023
• First Posted: May 25, 2023
• Study Start: November 10, 2022
• Primary Completion: August 1, 2024
• Study Completion: August 1, 2025
• Last Updated: May 30, 2023

Record last verified: 2023-05

Locations

NL (2)