The Links Between Executive and Linguistic Processes and Their Lesional Determinants From a Verbal Fluency Task

NCT05875103 | Recruiting

• 1 other identifier: PI2022_843_0150
• Study Type: interventional
• Target: 302
• Locations: 1 country
• Sites: 1

Brief Summary

Verbal fluency test require to produce as much words as possible in one or two minutes. This test is highly sensitive to main brain diseases and are therefore widely used in clinical routine for diagnostic purpose. The verbal fluency task requires several cognitive processes including executive and linguistic processes for which it is difficult to extract the origin of the deficit. For this reason, fluency tests are variably interpreted in terms of executive or language. The implementation of an experimental protocol exploring each of these processes separately and studying the links between the verbal fluency task and each of these processes should allow a better understanding of the origin of the verbal fluency deficit after brain injury and improve the identification of key brain structures. Indeed, the lesion determinants of this task remain to be clarified despite remarkable advances due to the evolution of imaging techniques (voxel-based lesion-symptom mapping (VLSM); voxel-based morphometry (VBM)). Furthermore, while the direct assessment of linguistic process, semantic memory, and processing speed is well defined, the examination of the executive component (i.e., strategic search process) remains unsettled and will be undertaken in this study. This work will take advantage of data from previous multicenter work, validated methodologies for both analysis and interpretation of cognitive performance as well as anatomic-clinical correlations at the voxel level and will be performed in cognitive neurodegenerative and cerebrovascular disease.

Conditions

Cognitive Neurodegenerative; Stroke; Verbal Fluency Disorders

Keywords

stroke; cognitive neurodegenerative; Verbal Fluency Disorders

Outcome Measures

Primary Outcomes (1)

• Corelation between Linguistic test performance score and verbal fluency score

  Linguistic processes are assessed by performance score on the following tests: * BNT 34 and semantic naming adapted from the BECS-GRECO * vocabulary test * repetition tests * articulatory speed * semantic matching task adapted from the PPT and from the BECS-GRECO * semantic categorization and attributes adapted from the BECS-GRECO * phonologic and semantic research tasks adapted from the color TMT

  1 hour

Study Arms (1)

Cognitive cortical neurodegenerative diseases and stroke PATIENTS

EXPERIMENTAL

Diagnostic Test: linguistic processes

Interventions

linguistic processes DIAGNOSTIC_TEST

Linguistic processes are assessed by performance score on the following tests: * naming tests : BNT 34 (Colombo \& Assal, 1992) and semantic naming adapted from the BECS-GRECO (Merck et al., 2011) * vocabulary test (Mill Hill - Deltour, 1993), * repetition tests (Gremots - Bézy et al., 2016), * articulatory speed (Majerus, 2014 ; Roussel et al., 2012) * semantic matching task adapted from the PPT (Howard \& Patterson, 1992) and from the BECS-GRECO (Merck et al., 2011), * semantic categorization and attributes adapted from the BECS-GRECO (Merck et al., 2011), * phonologic and semantic research tasks adapted from the color TMT (D'helia et al., 1996)

Cognitive cortical neurodegenerative diseases and stroke PATIENTS

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• For Cognitive cortical neurodegenerative diseases PATIENTS
• informed consentPatients between 40 and 85 years old,
• French native language,
• Social Security affiliation,
• Can read, write and count (up to 36) and knows the alphabet
• Assessed in Amiens University Memory Clinic for:
• Mild severity impairment (MMSE\> 19) or major severity impairment related to:
• AD according to Albert criteria and McKhann criteria
• DCL according to McKeith criteria
• FTLD according to Rascovsky criteria
• CBD according to Armstrong's criteria
• PSP according to Höglinger criteria
• For Stroke PATIENTS
• informed consent
• Patients between 40 and 85 years old,

You may not qualify if:

• Mental retardation or guardianship
• Other current or past brain condition affecting cognition, including:
• Severe head trauma
• Epilepsy prior to stroke still requiring previous treatment
• Parkinson disease, multiple sclerosis
• Brain tumor or brain radiation therapy
• Current or past schizophrenia or psychosis
• Active or past psychiatric impairments requiring a stay\> 2 days in a specialized environment
• Contra indication to MRI
• Comorbidity with life expectancy \<1 year
• Comorbidity affecting cognition in particular:
• Alcohol (\> 3 glasses / day) or history of alcohol withdrawal syndrome
• Opiate or cocaine addiction or opiate withdrawal syndrome
• Renal failure (dialysis or creatinine clearance \<30)
• Hepatic failure (spontaneous INR\> 1.5 or PT \<60%)

Sponsors & Collaborators

• Centre Hospitalier Universitaire, Amiens: lead

Study Sites (1)

CHU Amiens

Amiens, 80054, France

RECRUITING

MeSH Terms

Conditions

Stroke; Speech Disorders

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Language Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Martine ROUSSEL, PhD

CONTACT

0322668240; roussel.martine@chu-amiens.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 16, 2023
• First Posted: May 25, 2023
• Study Start: May 16, 2023
• Primary Completion (Estimated): November 1, 2029
• Study Completion (Estimated): November 1, 2029
• Last Updated: May 25, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)