Current Intensity for the Obturator Nerve Block

NCT05872451 | Completed

• 1 other identifier: ONB
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of the present study was to find out the difference in current intensity required for nerve stimulation according to the presence or absence of neuromuscular blockade during the obturator nerve block procedure for TURP.

Conditions

Bladder Tumor

Keywords

Transurethral Resection of Bladder; Obturator Nerve; Nerve Block; Neuromuscular Blockade; Anesthesia, General

Outcome Measures

Primary Outcomes (2)

• Initial current intensity

  The current intensity for the stimulation of the obturator nerve starts at 1.0 mA (using the sequential electrical nerve stimulation mode), and the needle is advanced gradually to the location where the stimulus response occurs at 0.3-0.5 mA. After fixing the needle position in a position where contraction of the adductor longus muscle responds to the minimum current intensity, measure the current intensity.

  About 5 minutes after starting obturator nerve block procedure

• Final current intensity

  After administration of rocuronium (0.6 mg/kg), when the train-of-four count becomes 0, the current intensity for the stimulation of the obturator nerve is increased until the contraction of the adductor longus muscle occurs. The current intensity is measured when the contraction of the adductor longus muscle occurs.

  About 10 minutes after starting obturator nerve block procedure

Secondary Outcomes (1)

• Current intensity after the administration of rocuronium (0.6 mg/kg)

  Between 5 minutes and 10 minutes after starting obturator nerve block procedure

Study Arms (1)

Current intensity

EXPERIMENTAL

1. An I-gel mask is inserted for the mechanical ventilator of the patient who is sedated with propofol. 2. For the ultrasound-guided obturator nerve (ON) block, and needle tip gradually advanced to the anterior branch of the ON. The current intensity for the stimulation of ON starts at 1.0 mA (using the sequential electrical nerve stimulation mode), and the needle is advanced gradually to the location where the contraction of the adductor longus muscle (ALM) occurs at 0.3-0.5 mA. 3. After fixing the needle in that position, measure the current intensity. 4. Then, rocuronium (0.6 mg/kg) is administered under quantitative neuromuscular-blockade monitoring. 5. When the train-of-four count becomes 0, the current intensity is increased until the contraction of the ALM occurs. 6. The current intensity is measured when the contraction of the ALM occurs.

Drug: Rocuronium Bromide; Diagnostic Test: Nerve stimulator

Interventions

Rocuronium Bromide DRUG

After measuring the initial current intensity, quantitative neuromuscular blockade monitoring is applied, and rocuronium (0.6 mg/kg) is administered.

Also known as: Rocuronium

Current intensity

Nerve stimulator DIAGNOSTIC_TEST

Measuring the minimum current intensity for the stimulation of the obturator nerve to show the contraction of the adductor longus muscle.

Also known as: Stimuplex

Current intensity

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients undergoing TURP procedure

You may not qualify if:

• Patients with anatomical or functional anomaly in the upper airways
• Patients with neuromuscular disease
• Patients with hip joint disorders
• BMI of \< 18.5 or \> 30.0 kg/m2

Sponsors & Collaborators

• Chosun University Hospital: lead

Study Sites (1)

Chosun University Hospital

Gwangju, 61453, South Korea

Location

Related Publications (1)

• Koo CH, Ryu JH. Anesthetic considerations for urologic surgeries. Korean J Anesthesiol. 2020 Apr;73(2):92-102. doi: 10.4097/kja.19437. Epub 2019 Dec 17.

  PMID: 31842248 BACKGROUND

MeSH Terms

Conditions

Urinary Bladder Neoplasms

Interventions

Rocuronium

Condition Hierarchy (Ancestors)

Urologic Neoplasms; Urogenital Neoplasms; Neoplasms by Site; Neoplasms; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Urinary Bladder Diseases; Urologic Diseases; Male Urogenital Diseases

Intervention Hierarchy (Ancestors)

Androstanols; Androstanes; Steroids; Fused-Ring Compounds; Polycyclic Compounds

Study Officials

• Ki Tae Jung, M.D., Ph.D.

  Chosun University Hospital

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Patients undergoing TURP procedure under general anesthesia

Study Record Dates

• First Submitted: May 12, 2023
• First Posted: May 24, 2023
• Study Start: July 1, 2023
• Primary Completion: April 15, 2024
• Study Completion: April 15, 2024
• Last Updated: August 22, 2024

Record last verified: 2024-08

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)