NCT05864612

Brief Summary

A randomized trial to compare patient-completion success of REDCap and Electronic Health Record (EHR)-based anxiety \& depression instrument delivery methods. Study hypothesis is that the screening completion proportion will vary across the 4 modalities tested.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
880

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Sep 2023

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 9, 2023

Completed
9 days until next milestone

First Posted

Study publicly available on registry

May 18, 2023

Completed
4 months until next milestone

Study Start

First participant enrolled

September 20, 2023

Completed
12 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 3, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 3, 2024

Completed
1.2 years until next milestone

Results Posted

Study results publicly available

October 30, 2025

Completed
Last Updated

October 30, 2025

Status Verified

September 1, 2024

Enrollment Period

12 months

First QC Date

May 9, 2023

Results QC Date

July 9, 2025

Last Update Submit

October 15, 2025

Conditions

Keywords

anxietydepressionscreening tools

Outcome Measures

Primary Outcomes (1)

  • Percentage of Subjects Completing Screening Instruments

    Percentage of subjects completing screening instruments by each of the 4 methods prior to clinic visit will be used to compare the effect of the different methods on patient self-completion, and to estimate completion rates by different methods for use in future screening implementation trials.

    Week 1

Secondary Outcomes (4)

  • Research Team Time-sending Instruments

    Baseline Day 0

  • Research Team Time-instrument Data Entry

    Week 1

  • Participant Time From Instrument Delivery to Completion

    Week 1

  • Percent Accuracy of Kit Application Programming Interface (API)

    Week 1

Other Outcomes (4)

  • Clinic Visit Attendance:Visit Completed

    Week 1

  • Clinic Visit Attendance:Visit Canceled

    Week 1

  • Clinic Visit Attendance: No-show

    Week 1

  • +1 more other outcomes

Study Arms (4)

Text Message

ACTIVE COMPARATOR

Subjects in this arm will be asked to complete standard care screening questionnaires on anxiety and depression, delivered by Twilio text message.

Behavioral: Screening Questionnaires

Customized Email Prompt

ACTIVE COMPARATOR

Subjects in this arm will be asked to complete standard care screening questionnaires on anxiety and depression, delivered by an email with a REDCap email survey link.

Behavioral: Screening Questionnaires

Generic Electronic Health Record (EHR) portal email

ACTIVE COMPARATOR

Subjects in this arm will be prompted with customized EHR portal message after login to EHR portal.

Behavioral: Screening Questionnaires

EHR Portal with No Message

ACTIVE COMPARATOR

Subjects in this arm will not receive a reminder, but previsit questionnaires associated with a visit will be in their EHR portal.

Behavioral: Screening Questionnaires

Interventions

Standard care screening questionnaires on anxiety and depression

Customized Email PromptEHR Portal with No MessageGeneric Electronic Health Record (EHR) portal emailText Message

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Visit scheduled 7 days in advance at an adult-focused epilepsy clinic at the study site

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Atrium Health Wake Forest Baptist

Winston-Salem, North Carolina, 27157, United States

Location

MeSH Terms

Conditions

EpilepsyAnxiety DisordersDepression

Condition Hierarchy (Ancestors)

Brain DiseasesCentral Nervous System DiseasesNervous System DiseasesMental DisordersBehavioral SymptomsBehavior

Results Point of Contact

Title
Heidi Munger-Clary, MD, MPH, FACNS, FAES
Organization
Wake Forest University Health Sciences

Study Officials

  • Heidi M. Munger Clary, MD, MPH

    Wake Forest University Health Sciences

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Model Details: The four instrument delivery methods to be used in this pragmatic trial represent distinct prompts \& cues for screening instrument completion. Examining these multiple instrument delivery methods will generate outputs that will support flexibility in instrument delivery modalities across multiple sites in future multicenter studies in this area. These 4 distinct delivery methods are used to deliver identical standard care validated anxiety and depression screening instruments.
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 9, 2023

First Posted

May 18, 2023

Study Start

September 20, 2023

Primary Completion

September 3, 2024

Study Completion

September 3, 2024

Last Updated

October 30, 2025

Results First Posted

October 30, 2025

Record last verified: 2024-09

Data Sharing

IPD Sharing
Will share

After the study is completed and results published by primary study team, de-identified, archived data will be stored for potential use if requested by other qualified researchers including those outside of the study.

Shared Documents
STUDY PROTOCOL, ICF
Time Frame
After the study is completed and results published, de-identified, archived data will be available upon request.

Locations