Developing and Optimizing Transcranial Magnetic Stimulation for Motor Rehabilitation

NCT05861284 | Withdrawn

• 1 other identifier: IRB_2303032088
• Study Type: interventional
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aims to evaluate three different transcranial magnetic stimulation protocols and their impact on motor system neurophysiology and skill learning.

Conditions

Motor Cortex; Motor Skills

Keywords

TMS; Motor system; Healthy

Outcome Measures

Primary Outcomes (3)

• Effect of TMS on motor evoked potentials

  Amplitude of the motor evoked potentials in millivolts.

  Up to 1 second after TMS

• Skill learning accuracy

  Skill learning accuracy as the total number of correct responses.

  Up to 12 minutes

• Skill learning speed

  Skill learning speed in seconds.

  Up to 12 minutes

Study Arms (3)

Single-pulse TMS over the primary motor cortex

EXPERIMENTAL

We will administer single-pulse TMS to the primary motor cortex while measuring motor responses and just before a skill-learning task.

Device: Transcranial Magnetic Stimulation (TMS)

Paired-pulse TMS over the primary motor cortex

EXPERIMENTAL

We will administer paired-pulse TMS to the primary motor cortex while measuring motor responses and just before a skill-learning task.

Device: Transcranial Magnetic Stimulation (TMS)

Sham TMS over the primary motor cortex

SHAM COMPARATOR

We will administer sham TMS to the primary motor cortex while measuring motor responses and before a skill-learning task.

Device: Transcranial Magnetic Stimulation (TMS)

Interventions

Transcranial Magnetic Stimulation (TMS) DEVICE

Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method that can induce long-term changes in connections between neuronal networks.

Paired-pulse TMS over the primary motor cortex; Sham TMS over the primary motor cortex; Single-pulse TMS over the primary motor cortex

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• years old
• Able to read, understand, and sign the informed consent in English
• Right-handed

You may not qualify if:

• A sensory or physical impairment
• History of epilepsy or seizures in the family
• Non-removable metal or electronics (e.g., a cochlear implant, cardiac pacemaker, or implanted electronic devices) in your head or body
• A head injury with loss of consciousness
• Diagnosis of psychiatric or neurological disorder
• Skin defects or active infections on the scalp or hands
• Pregnancy or breastfeeding

Sponsors & Collaborators

• Elisa Kallioniemi: lead

MeSH Terms

Interventions

Transcranial Magnetic Stimulation

Intervention Hierarchy (Ancestors)

Magnetic Field Therapy; Therapeutics

Study Officials

• Elisa Kallioniemi, Ph.D.

  New Jersey Institute of Technology

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: April 27, 2023
• First Posted: May 16, 2023
• Study Start (Estimated): July 1, 2026
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: April 13, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: Data will be shared only upon request after the study has ended (within 6 months).
• Access Criteria: To receive access, the study investigators must be contacted via an institutional e-mail.