Does Muscle Mass At Intensive Care Unit Admission Determine Mortality: the Memo Study

NCT05834894 | Active Not Recruiting

• 1 other identifier: 2022-01773
• Study Type: observational
• Target: 4,000
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective monocentric study aims to investigate whether a low muscle mass at ICU admission and its loss over the ICU stay predicts mortality, and in what proportion we can counteract it by nutritional support.

Conditions

Lean Body Mass

Keywords

Muscle mass; Skeletal muscle area; Third lumbar; Tomography; Intensive care unit

Outcome Measures

Primary Outcomes (1)

• 30-day mortality

  Association between skeletal muscle index (SMI) at the L3 vertebra level (psoas + abdominal wall muscles + paraspinal muscles), measured from 48 hours before to 96 hours after ICU admission, with 30-day mortality.

  30-day mortality between January 1st 2010 and December 31st 2022.

Secondary Outcomes (5)

• Association of baseline body composition at ICU admission with other outcomes

  30-day

• Association of baseline SMI at the L3 vertebra level vs. other locations to predict outcomes

  Day 1 to day 30

• Association of body composition changes with outcomes

  Day 30

• Association of body composition changes with nutritional support

  Day 30

• Association of muscle loss with medico-economical parameters

  Day 30

Interventions

exposure(s) of interest : intensive care unit OTHER

Low muscle mass is highly prevalent at hospital admission, and muscle mass generally decreases during hospital stay, especially in critically-ill patients. We would like to mesure muscle mas in critically ill patients and determine the association between outcomes.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults ≥ 18 yrs, hospitalized in the ICU of the HUG between January 1st 2010 and December 31st 2022

You may qualify if:

• Associations of baseline body composition with clinical outcomes:
• Adults ≥ 18 yrs, hospitalized in the ICU of the HUG between January 1st 2010 and December 31st 2022 and Abdominal, or thoraco-abdominal CT scan measured 48 hours before to 96 hours after ICU admission in the HUG
• Associations of body composition changes with clinical outcomes, nutritional support or medico-economic paratemers:
• Identical as for the associations of baseline body composition with clinical outcomes and At least one additional CT performed during the hospital stay

You may not qualify if:

• Associations of baseline body composition with clinical outcomes:
• CT scans of low quality or CT scans performed outside of the HUG or Presence of a documented refusal
• Associations of body composition changes with clinical outcomes, nutritional support or medico-economic paratemers:
• Additionnally: oral nutrition, because we cannot assess the quantity and composition of oral intakes retrospectively

Sponsors & Collaborators

• University Hospital, Geneva: lead
• VBertoniMaluf: collaborator

Study Sites (1)

Laurence Genton

Geneva, Canton of Geneva, 1211, Switzerland

Location

Related Publications (1)

• Genton L, Bertoni Maluf VA, Herrmann FR, Prado CM, de Watteville A, Dupertuis YM, Collet TH, Platon A, Heidegger CP. Obesity is associated with lower 30-day mortality in critically ill patients: A retrospective study of over 5400 patients. Clin Nutr ESPEN. 2025 Oct;69:37-44. doi: 10.1016/j.clnesp.2025.06.046. Epub 2025 Jun 30.

  PMID: 40602605 DERIVED

Study Officials

• Laurence Genton, MD

  University Hospital, Geneva

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof.

Study Record Dates

• First Submitted: April 17, 2023
• First Posted: April 28, 2023
• Study Start: January 1, 2010
• Primary Completion: May 31, 2025
• Study Completion: October 31, 2025
• Last Updated: December 6, 2024

Record last verified: 2024-12

Locations

CH (1)