Novel Equations for Estimating Lean Body Mass in Patients With Chronic Kidney Disease

NCT04074278 | Completed

• 1 other identifier: LBM eqations
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

Simplified methods to estimate lean body mass (LBM), an important nutritional measure representing muscle mass and somatic protein, are lacking in non-dialyzed patients with chronic kidney disease (CKD). Objective: We developed and tested a reliable equations for estimation of LBM in daily clinical practice.

Conditions

Lean Body Mass; Chronic Kidney Diseases

Keywords

mid-arm muscle circumference; handgrip strength; dual-energy x-ray absorptiometry

Outcome Measures

Primary Outcomes (1)

• LBM_DEXA

  lean body mass measured by dual-energy x-ray absorptiometry (DEXA)

  between March 1st, 2014 and December 1st, 2015

Study Arms (2)

development groups

The development groups included 150 patients derived from outpatients in Peking University First Hospital, between March 1st, 2014 and November 26th 2014.

validation groups

The validation groups included 150 patients derived from outpatients in Peking University First Hospital, between November 27th 2014 and December 1st, 2015.

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The development and validation groups both included 150 non-dialyzed patients with CKD stage 3-5.

You may qualify if:

• non-dialyzed patients with CKD stage 3-5
• clinical stable
• a willingness to be examined with all measurements being taken simultaneously.

You may not qualify if:

• systemic infections, acute cardiovascular events, operations, trauma, active hepatitis or tumor
• severe edema within one month prior to the study
• chronic infections, connective tissue disease, hyper- or hypothyroidism, amputations or pregnancy,
• taking immunosuppressive agents and anti-inflammatory medication chronically

Sponsors & Collaborators

• Peking University First Hospital: lead

Study Sites (1)

Renal Division and Institute of Nephrology, Peking University First Hospital

Beijing, Beijing Municipality, 100034, China

Location

MeSH Terms

Conditions

Renal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Professor of Institute of Nephrology, Division of Renal

Study Record Dates

• First Submitted: August 28, 2019
• First Posted: August 30, 2019
• Study Start: March 1, 2013
• Primary Completion: December 1, 2015
• Study Completion: December 1, 2015
• Last Updated: September 10, 2019

Record last verified: 2019-09

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)