A Study of the Intervention Effect of a Hybrid Exercise Program on Frail Elderly

NCT05832853 | Completed

• 1 other identifier: CCEE2018
• Study Type: interventional
• Target: 181
• Locations: 1 country
• Sites: 1

Brief Summary

The declining physical condition of frail elderly is becoming an ugent problem. Although the exercise intensity of Wu Qin Xi appears to be low, it is highly effective in the older individuals. Inspired by the characteristics and functions of Wu Qin Xi, we designed a brand new exercise intervention training program among frail older people, which incorporates Wu Qin Xi, strength exercises and endurance exercises to improve physical fitness, and even reverse the condition of frailty. Furthermore, to improve utility in clinical practice, we innovatively employed machine learning simulations to infer the condition of older adults and predict their level of frailty after the intervention.

Conditions

Frail Elderly Syndrome

Keywords

frailty; exercise intervention

Outcome Measures

Primary Outcomes (4)

• Assessing the endurance of frail older adults using the six-minute walk test

  Assessment of endurance in frail older adults before and after intervention using the six-minute walk test

  Month 6

• Assessing the speed of frail older adults using the ten-meter maximum walk speed

  Assessment of speed in frail older adults before and after intervention using ten-meter maximum walk speed.

  Month 6

• Using handgrip strength tests to assess strength in frail older adults.

  Using handgrip strength tests to assess strength in frail older adults before and after intervention

  Month 6

• Assessment of balance in frail older adults using Time Up and Go Test.

  Assessment of balance in frail older adults before and after intervention using Time Up and Go Test.

  Month 6

Study Arms (3)

Wu Qin Xi exercise

EXPERIMENTAL

The training schedule for Wu Qin Xi consisted of two phases: the first phase lasted for eight weeks, while the second phase lasted for 16 weeks. In the first phase, Wu Qin Xi group was given twice repetitions of the intervention. The second phase consisted of three repetitions of the Wu Qin Xi group.

Behavioral: Wu Qin Xi exercise

Wu Qin Xi, resistance training and endurance training

EXPERIMENTAL

The trial was divided into three cycles, each lasting eight weeks. Participants performed a hybrid program of Wu Qin Xi exercise, resistance training and endurance training of varying duration and intensity in each cycle. Each session lasted one hour, three times a week for 24 weeks.

Behavioral: Wu Qin Xi, resistance training and endurance training

Resistance training and endurance training

EXPERIMENTAL

The trial was divided into three cycles, each lasting eight weeks. Participants performed a hybrid program of resistance training and endurance training of varying duration and intensity in each cycle. Each session lasted one hour, three times a week for 24 weeks.

Behavioral: Resistance training and endurance training

Interventions

Wu Qin Xi exercise BEHAVIORAL

The training schedule for Wu Qin Xi consisted of two phases: the first phase lasted for eight weeks, while the second phase lasted for 16 weeks. In the first phase, Wu Qin Xi group was given twice repetitions of the intervention. The second phase consisted of three repetitions of the Wu Qin Xi group. Participants warmed up for 20 min prior to the intervention and cooled down for 10 min at the end.

Wu Qin Xi exercise

Wu Qin Xi, resistance training and endurance training BEHAVIORAL

During the first 8 weeks, the training consists of learning and consolidating the movements of the Wu Qin Xi. In the second 16 weeks, participants perform a full set of movement exercises. Each resistance training session contained two lower-body exercises (seated calf raises and hip abduction) and three upper-body exercises (lateral pull downs, biceps curls, and triceps push downs) and two sets for each exercise. Endurance training is performed by continuous walking on an undisturbed indoor track for 15 min. Participants warmed up for 20 min prior to the intervention and cooled down for 10 min at the end.

Wu Qin Xi, resistance training and endurance training

Resistance training and endurance training BEHAVIORAL

Each resistance training session contained two lower-body exercises (seated calf raises and hip abduction) and three upper-body exercises (lateral pull downs, biceps curls, and triceps push downs) and three sets for each exercise. Endurance training is performed by continuous walking on an undisturbed indoor track for 30 min. Participants warmed up for 20 min prior to the intervention and cooled down for 10 min at the end.

Resistance training and endurance training

Eligibility Criteria

• Age: 60 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• a Fried frailty phenotype score of 3-5 points;
• could walk for at least 6 min without support;
• had not been able to walk in the past year other training.

You may not qualify if:

• people who have a past mental illness or serious psychological issues which make it difficult to obey orders;
• people who have had neurological disorders within the last six months;
• people who must regularly participate in other training programs during the study period;
• people who struggle to walk normally due to significant muscle and skeletal injuries and continuous joint discomfort.

Sponsors & Collaborators

• Guang Yang, Prof. Dr.: lead

Study Sites (1)

Chinese Center of Exercise Epidemiology

Changchun, Jilin, 130024, China

Location

Related Publications (1)

• Wei M, He S, Meng D, Yang G, Wang Z. Hybrid Exercise Program Enhances Physical Fitness and Reverses Frailty in Older Adults: Insights and Predictions from Machine Learning. J Nutr Health Aging. 2023;27(10):894-902. doi: 10.1007/s12603-023-1991-0.

  PMID: 37960913 DERIVED

MeSH Terms

Conditions

Frailty

Interventions

Resistance Training; Endurance Training

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Prof.Dr.

Study Record Dates

• First Submitted: April 16, 2023
• First Posted: April 27, 2023
• Study Start: May 20, 2018
• Primary Completion: December 30, 2018
• Study Completion: January 30, 2019
• Last Updated: April 27, 2023

Record last verified: 2023-04

Locations

CN (1)