Evolution of Pulsed Oxygen Saturation During Interval Training Compared to Continuous Training in COPD Patients

NCT05825638 | Completed

• 1 other identifier: 2022-A02087-36
• Study Type: observational
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

A problem often observed during exercise training is oxygen desaturation exclusively during exercise in some patients. In the case of exercise-induced desaturation, it may be suggested to train these patients in interval training to limit exercise-induced desaturation. Interval training consists of alternating active phases of short duration (often 30 seconds to 1 minute) followed by a short active or passive recovery phase of equivalent duration to the previous phase. Investigators therefore hypothesise that interval training on a cycloergometer or treadmill can limit exercise-induced desaturation in COPD patients. The aim of the study is to observe the evolution of pulsed oxygen saturation between a continuous training session and a interval training session.

Conditions

COPD; Exercise; Desaturation of Blood; Pulmonary Rehabilitation

Keywords

COPD; Pulmonary rehabilitation; Interval training

Outcome Measures

Primary Outcomes (1)

• Difference in oxygen pulsed saturation

  Difference in minimum saturation during both exercise, the measurement will be performed with a pulse oximeter (Spirodoc, MIR)

  One week

Secondary Outcomes (7)

• Difference in oxygen pulsed saturation

  One week

• Difference in peripheral muscle oxygenation

  One week

• Difference in respiratory rate

  One week

• Difference in tidal volume

  One week

• Difference in inspiratory capacity

  One week

Study Arms (2)

Continuous training session

Other: Continuous training session

Interval Training session

Other: Interval training session

Interventions

Interval training session OTHER

Interval training consists of a 5-minute warm-up, a 5-minute cool-down and 20 minutes of alternating 60 seconds of high-intensity work (100% of the maximum power recorded in the incremental test that was carried out when the patient was admitted to the pulmonary rehabilitation department) and 60 seconds of unloaded pedalling or rest.

Interval Training session

Continuous training session OTHER

Continuous training consists of a 5 minute warm up, 5 minute cool down and 20 minutes of moderate intensity work. The workload is set at 60% of the patient's maximum power

Continuous training session

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with COPD who meet the inclusion criteria will be offered to participate in this study during a pulmonary rehabilitation programme which will take place in the pneumology rehabilitation department of the Le Havre Hospital. If the patient wishes to participate in the study, he/she will be given an information note containing a declaration of non-opposition which he/she will have to complete and sign.

You may qualify if:

• a diagnosis of COPD
• participating in a pulmonary rehabilitation programme
• with an exercise-induced desaturation less than 90%
• no oxygen supplementation

You may not qualify if:

• Under 18 years of age
• Pregnant woman
• Person not affiliated to a health insurance regime or not benefiting from a social security regime
• Patient under curatorship, guardianship or safeguard of justice
• Patient speaking a language other than French
• Patient with severe hypoxaemia (SpO2 ≤ 80%) during exercise
• Patient having had a moderate or severe exacerbation (hospitalisation for respiratory reasons) in the previous 4 weeks
• Patients with orthopaedic, rheumatic, vascular or neurological pathology limiting their ability to make an effort
• Breastfeeding women

Sponsors & Collaborators

• Medrinal Clement: collaborator
• Combret Yann: collaborator
• Machefert Margaux: collaborator
• Groupe Hospitalier du Havre: lead

Study Sites (1)

Groupe Hospitalier du Havre

Le Havre, Normandy, 76290, France

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive; Motor Activity

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Behavior

Study Officials

• Guillaume Prieur, PT, PhD

  Groupe Hospitalier du Havre

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: January 10, 2023
• First Posted: April 24, 2023
• Study Start: January 10, 2023
• Primary Completion: September 30, 2025
• Study Completion: October 10, 2025
• Last Updated: January 21, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will share
• Shared Documents: SAP, CSR
• Time Frame: after publication
• Access Criteria: the request shall be sent to Guillaume Prieur (gprieur.kine@gmail.com)

Locations

FR (1)