Oxygen Dissociation Curve in Patients Undergoing Orthotopic Liver Transplantation

NCT05822570 | Completed

• 1 other identifier: O2DO2 in LTX
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Hemoglobin (Hb) is the molecule responsible for the transport of oxygen (O2) to the tissues in mammals. The p50 and the Hill coefficient (HC) best describe the ODC. The interaction between Hb and O2 can be influenced by many agents and conditions like temperature, pH, pCO2 and 2,3-diphosphoglycerate (2,3-DPG). During liver transplantation numerous profound physiological changes occur, linked to the different stages of the surgical procedure. Previous studies in humans and animals undergoing liver transplantation have shown that while the ODC seems preserved during preparation and the anhepatic phase, a left shift of the ODC occurs after reperfusion . This left shift of the ODC could imply a decreased release of oxygen to the tissues, probably worsening hemodynamic instability. With this pilot study the investigator aim to measure ODCs at baseline and at different stages during orthotopic liver transplantation in patients in order to get deeper understanding of oxygen delivery and supply during liver transplantation surgery.

Conditions

Liver Transplantation

Keywords

Liver Transplantation; Oxygen dissociation curve

Outcome Measures

Primary Outcomes (1)

• Oxygen Dissocation Curve

  Oxgen delivery curve characteristics based on p50 values, Hill-coefficient and 2,3 DPG

  24 hours

Interventions

Assessment of Oxygen Dissociation Curve (ODC) DIAGNOSTIC_TEST

ODC will be assessed at 5 timepoints: T0 after installation of arterial catheter, T1 before clamping of the liver, T2 5-10 min before reperfusion of the liver graft, T3 45 min after reperfusion, T4 1 h after T3 or at end of surgery

Eligibility Criteria

• Age: 18 Years - 99 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients scheduled for orthotopic liver transplantation

You may qualify if:

• Patien scheduled for LTX
• Age 18 years to 99 years
• Signed informed content form.

You may not qualify if:

• Known hemoglobinopathy
• Need for more than 3 packed erythrocytes before assessment at T4.
• preoperative predicted need for more than 3 based on study team
• MELD score \< 10
• stay at high attitude (\>3000 m) for more days over the last 4 weeks

Sponsors & Collaborators

• Medical University Innsbruck: lead

Study Sites (1)

Medical University Innsbruck

Innsbruck, Tyrol, 6020, Austria

Location

Biospecimen

Retention: SAMPLES WITH DNA

Blood

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 6, 2023
• First Posted: April 20, 2023
• Study Start: May 1, 2023
• Primary Completion: September 30, 2024
• Study Completion: October 31, 2024
• Last Updated: March 26, 2025

Record last verified: 2024-11

Locations

AU (1)