Comparing Montiroing Cardiac Index by Transpulmonary Thermodilution and Transesophageal Echocardiography During Liver Transplantation

NCT06899867 | Recruiting

• 1 other identifier: 24-5431
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Liver transplantation poses challenges due to hemodynamic changes throughout different surgical phases. Monitoring devices are essential for therapeutic adjustments. Transpulmonary thermodilution and transesophageal echocardiography are commonly used, but thermodilution may have limitations depending on the surgery. This study aims to compare cardiac index variations between thermodilution and transesophageal echocardiography during liver transplantation. Patients undergo monitoring with both techniques. Measurements are recorded and reported at multiple time points.

Conditions

Liver Transplantation

Outcome Measures

Primary Outcomes (1)

• Cardiac index variation measured by thermodilution compared with transesophageal echography

  At 4 times of surgery: after starting anesthesia, anhepatic phase, reperfusion and surgical anastomosis of biliary ducts. Data reported : - Cardiac Index before and after end-expiratory test. - Transoesophageal echography measurement of cardiac function

Study Arms (1)

Patients undergoing liver transplantation at Croix-Rousse University Hospital, HCL, Lyon.

* Monitoring transesophageal echography, transpulmonary thermodilution * Measuring cardiac index, preload dependence (end-expiratory test) at 4 steps of surgery * Surgical anastomosis echography * Demographic data, biological data, post operation data

Other: Measure of cardiac index with thermodilution and transesophageal echocardiography; Other: Surgical anastomosis echography

Interventions

Measure of cardiac index with thermodilution and transesophageal echocardiography OTHER

At 4 times of surgery, end-expiratory occlusion (EEO) test and measure of cardiac index before and after test with ETO and thermodilution

Patients undergoing liver transplantation at Croix-Rousse University Hospital, HCL, Lyon.

Surgical anastomosis echography OTHER

Visualisation of surgical anastomosis through transesophageal echocardiography : stenosis, doppler velocity, collar diameter

Patients undergoing liver transplantation at Croix-Rousse University Hospital, HCL, Lyon.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

age \> 18 years old, undergoing liver transplantation at Croix-Rousse hospital, HCL, Lyon

You may qualify if:

• liver transplantation
• adults

You may not qualify if:

• \- Oesophageal varice ligation \< 14 days
• Mediastinal radiotherapy
• Femoral bypass
• Severe lower extremity artery disease

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (1)

Croix Rousse Hsopital

France, Lyon, 69004, France

RECRUITING

MeSH Terms

Interventions

Thermodilution

Intervention Hierarchy (Ancestors)

Indicator Dilution Techniques; Investigative Techniques

Central Study Contacts

Pr Alice Blet

CONTACT

371239; alice.blet@chu-lyon.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 21, 2025
• First Posted: March 28, 2025
• Study Start: November 27, 2023
• Primary Completion: July 1, 2024
• Study Completion: November 1, 2025
• Last Updated: March 28, 2025

Record last verified: 2025-03

Locations

FR (1)