Addressing Tetrachloroethylene Exposure in an Impacted Community

NCT05819996 | Recruiting

• 1 other identifier: 20211507
• Study Type: interventional
• Target: 510
• Locations: 1 country
• Sites: 1

Brief Summary

Groundwater in Martinsville, IN, is contaminated by volatile organic compounds (VOCs), tetrachloroethylene (PCE) and trichloroethylene (TCE). Indoor air in some residential and commercial buildings is also contaminated with PCE and TCE. This study is being conducted to better understand the impact of low-level exposures to these compounds on community members' health. Data collected in this study will be used to help the community identify a course of action.

Conditions

Vapors; Inhalation; Cancer; Volatile Organic Compounds

Keywords

Tetrachloroethylene; Trichloroethylene; PCE; TCE; Community environmental contamination; Chlorinated volatile organic compounds

Outcome Measures

Primary Outcomes (3)

• Change in concerns about environmental chemical contamination in Martinsville.

  This measure is based on the differences between the percentage of "Yes" responses to a close-ended, not scaled question at 3 different time points, administered via repeated surveys to the same sample of respondents. Are participants concerned about environmental chemical contamination in Martinsville? Yes / Somewhat / No / Refuse 1a. Changes in concerns about environmental chemical contamination in Martinsville from Year 1 to Year 3. This is based on the differences in percentage of yes responses to this question in surveys administered in Year 1 (Main survey, baseline) and Year 3 (online survey administered at the beginning of Year 3). 1b. Changes in concerns about environmental chemical contamination in Martinsville from Year 1 to Year 5. This is based on the differences in percentage of yes responses to this question in surveys administered in Year 1 (Main survey, baseline) and Year 5 (Online survey, post intervention).

  For Measure 1a, Time frame is from year 1 to year 3; for Measure 1b, Time frame is from year 1 to year 5.

• Changes in awareness of possible exposure to chemicals from soil or groundwater in Martinsville.

  This measure is based on the differences between the percentage of "Yes" responses to a close-ended, not scaled question at 3 different time points, administered via repeated surveys to the same sample of respondents. Are participants aware of possible exposure to chemicals from soil or groundwater in Martinsville? Yes / No / Refuse 2a. Changes in awareness of possible exposure to chemicals from soil or groundwater in Martinsville from Year 1 to Year 3. This is based on the differences in percentage of yes responses to this question in surveys administered in Year 1 (Main survey, baseline) and Year 3 (Online survey administered at the beginning of Year 3). 2b. Changes in awareness of available resources for exposure reduction from Year 1 to Year 5. This is based on the differences in surveys administered in Year 1 (Main survey, baseline) and Year 5 (Online survey, post intervention)

  For Measure 2a, Time frame is from year 1 to year 3; for Measure 2b, Time frame is from year 1 to year 5.

• Change in willingness to have respondent's homes tested for chemical contamination from contaminated soil or groundwater.

  This measure is based on the difference between the percentage of "Yes" responses to a close-ended, not scaled question at 3 different time points, administered via repeated surveys to the same sample of respondents. Are participants willing to have their home tested for chemical contamination from contaminated soil or groundwater? Yes / No / Refuse / Don't know 3a. Changes in willingness to have respondents' homes tested for the chemical contamination from Year 1 to Year 3. This is based on the differences in percentage of yes responses to this question in surveys administered in Year 1 (Main survey, baseline) and Year 3 (Online survey at the beginning of Year 3) 3b. Changes in willingness to have respondents' homes tested for the chemical contamination from Year 1 to Year 5. This is based on the differences in differences in percentage of yes responses to this question in surveys administered in Year 1 (Main survey, baseline) and Year 5 (Online survey, post intervention)

  For Measure 3a, Time frame is from year 1 to year 3; for Measure 3b, Time frame is from year 1 to year 5.

Study Arms (1)

Martinsville Residents

OTHER

Residents of Martinsville, Indiana, will receive educational campaign promoting participation in environmental testing

Behavioral: Environmental educational campaign

Interventions

Environmental educational campaign BEHAVIORAL

Educational campaign will be conducted to promote participation in indoor air testing.

Martinsville Residents

Eligibility Criteria

• Age: 18 Years - 99 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Residents of Martinsville, Indiana
• years or older

Sponsors & Collaborators

• Purdue University: lead
• University of Illinois at Chicago: collaborator
• Indiana University School of Medicine: collaborator
• Mackey Children's Cancer Foundation: collaborator

Study Sites (1)

Purdue University

West Lafayette, Indiana, 47907, United States

RECRUITING

MeSH Terms

Conditions

Respiratory Aspiration; Neoplasms

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Sa Liu, MPH, PhD

  Purdue University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Sa Liu, MPH, PhD

CONTACT

765-496-6240; saliu@purdue.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Prof.

Model Details: An educational campaign targeting the community

Study Record Dates

• First Submitted: December 5, 2022
• First Posted: April 19, 2023
• Study Start: February 17, 2023
• Primary Completion (Estimated): May 31, 2028
• Study Completion (Estimated): May 31, 2028
• Last Updated: March 18, 2025

Record last verified: 2024-05

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)