NCT05763797

Brief Summary

To determine the feasibility of implementing a culturally adapted mind-body intervention (Meditation-Based Support-Adapted; MBS-A) as a supportive care strategy in Black patients diagnosed with a stage III-IV solid malignancy. To target the specific needs of Black advanced cancer patients, we will first conduct formative research that includes quantitative surveys and in-depth interviews of patients and their primary caregivers. The purpose of this formative research is to determine the intervention format for the MBS-A program (family- vs group-based) that promises the greatest likelihood of success and to solicit input on the original MBS intervention regarding content that needs adaptation. Once the intervention format is determined and content adapted, we will conduct a pilot randomized controlled trial (RCT) to examine the feasibility of the MBS-A intervention vs. a dose-matched attention control (AC) group receiving a psychoeducation intervention.

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
170

participants targeted

Target at P50-P75 for not_applicable cancer

Timeline
36mo left

Started Apr 2023

Longer than P75 for not_applicable cancer

Geographic Reach
1 country

1 active site

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress51%
Apr 2023Mar 2029

First Submitted

Initial submission to the registry

February 28, 2023

Completed
10 days until next milestone

First Posted

Study publicly available on registry

March 10, 2023

Completed
1 month until next milestone

Study Start

First participant enrolled

April 13, 2023

Completed
4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 31, 2027

Expected
2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

March 31, 2029

Last Updated

March 11, 2026

Status Verified

March 1, 2026

Enrollment Period

4 years

First QC Date

February 28, 2023

Last Update Submit

March 10, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • MD Anderson Symptom Inventory-Score Scale

    MD Anderson Symptom Inventory, which consists of 13 core items assessing symptom severity and 6 items assessing symptom interference with daily living.71,72 If the family-based format is selected, patients and caregivers will complete the form as it applies to their own symptoms as well as their perceptions of each other's symptoms.73 MD Anderson Symptom Inventory-Score Scale "at its worst" using 0-10 numerical rating scales with 0 = "not present" and 10 = "as bad as you can imagine."

    through study completion; an average of 1 year.

Study Arms (3)

Aim 1 (individual interview)

EXPERIMENTAL

Participants will be interviewed

Behavioral: Individual InterviewBehavioral: Meditation Exercise

Aim 2 (supportive care program)

EXPERIMENTAL

Participants will be assigned to one of two groups

Behavioral: Individual InterviewBehavioral: Meditation Exercise

Aim 3 (supportive care program)

EXPERIMENTAL

Participants will be assessed regarding their program participation

Behavioral: Individual InterviewBehavioral: Meditation Exercise

Interventions

Group 1, participant will be in a supportive care program with other Black cancer patients in which you will practice meditation. Group 2, participate will be in a supportive care program with other Black cancer patients that focuses on coping with cancer. Participants will be asked to participate weekly sessions for 4 weeks (that is a total of 4 sessions) and each session will last about 60 minutes. Both groups will be delivered via Zoom (a web-based videoconferencing service) and led by a master's-level interventionist.

Aim 1 (individual interview)Aim 2 (supportive care program)Aim 3 (supportive care program)

Group 1, participant will be in a supportive care program with other Black cancer patients in which you will practice meditation. Group 2, participate will be in a supportive care program with other Black cancer patients that focuses on coping with cancer. Participants will be asked to participate weekly sessions for 4 weeks (that is a total of 4 sessions) and each session will last about 60 minutes. Both groups will be delivered via Zoom (a web-based videoconferencing service) and led by a master's-level interventionist.

Aim 1 (individual interview)Aim 2 (supportive care program)Aim 3 (supportive care program)

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • For Aim 1, in order to be eligible to participate in this study, a patient must meet all of the following criteria:
  • Self-identifies as Black/African American
  • Is ≥18 years old
  • Was diagnosed with a stage III-IV solid tumor
  • Is able to provide informed consent
  • For Aims 2 and 3, in order to be eligible to participate in this study, a patient must meet all of the following criteria:
  • Self-identifies as Black/African American
  • Is ≥18 years old
  • Was diagnosed with a stage III-IV solid tumor
  • Is on active treatment (any line)
  • Has an ECOG performance status of ≤2
  • Has access to the internet
  • Is able to provide informed consent
  • For Aims 2 and 3, if a family-based intervention is selected as the program format, a patient must meet the additional following criterion:
  • Has a family caregiver (e.g., spouse, adult child) with whom they currently reside
  • +4 more criteria

You may not qualify if:

  • For Aims 2 and 3, a patient who meets any of the following criteria will be excluded from participation in this study:
  • Is pregnant
  • Has cognitive deficits that would impede the completion of self-report instruments as deemed by the clinical team
  • Participated in in the Aim 1 of this study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

M D Anderson Cancer Center

Houston, Texas, 77030, United States

Location

Related Links

MeSH Terms

Conditions

Neoplasms

Study Officials

  • Dalnim Cho, PhD

    M.D. Anderson Cancer Center

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
SUPPORTIVE CARE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 28, 2023

First Posted

March 10, 2023

Study Start

April 13, 2023

Primary Completion (Estimated)

March 31, 2027

Study Completion (Estimated)

March 31, 2029

Last Updated

March 11, 2026

Record last verified: 2026-03

Locations