Information of the Coma Recovery Scale-Revised for Neurobehavioral State and Recovery of Consciousness Prediction

NCT05819177 | Completed

• 1 other identifier: CRS-R_Info
• Study Type: observational
• Target: 171
• Locations: 1 country
• Sites: 2

Brief Summary

Background: The Coma Recovery Scale-Revised (CRS-R) is the most recommended instrument to examine the neurobehavioral condition of individuals with disorders of consciousness (DOCs). Different studies have investigated the prognostic value of the information provided by the conventional administration of the scale, while other measures derived from the scale have been proposed to improve the prognosis of DOCs. However, the heterogeneity of the data used in the different studies prevents a reliable comparison of the identified predictors and measures. Objectives: This study investigates which information derived from the CRS-R provides the most reliable prediction of both the neurobehavioral state and recovery of consciousness at the discharge of a long-term neurorehabilitation program. Methods: The clinical records of 171 individuals with DOCs admitted to an inpatient neurorehabilitation program for a minimum of 3 months were used to implement machine learning classifiers that were trained to predict the neurobehavioral state and recovery of consciousness at discharge.

Conditions

Disorder of Consciousness

Keywords

Disorders of consciousness; Unresponsive wakefulness syndrome; Minimally conscious state; Severe brain injury; Prognosis; Machine learning

Outcome Measures

Primary Outcomes (2)

• Recovery of consciousness

  Described as Emergence from Minimal Consciousness State (MCS) or from Unresponsive Wakefulness Syndrome (UWS) (1) or presence of Disorder of Consciousness (DoC, 0)

  At discharge from the rehabilitation hospital (median of 365 days)

• Neurobehavioral state

  Described as Minimal Consciousness State (MCS), Unresponsive Wakefulness Syndrome (UWS), or Emergence from Minimal Consciousness State (E-MCS)

  At discharge from the rehabilitation hospital (median of 365 days)

Study Arms (1)

Cohort undergoing rehabilitation

This group of patients underwent standard rehabilitation programs set by national guidelines.

Other: Rehabilitation program

Interventions

Rehabilitation program OTHER

This group of patients underwent standard rehabilitation programs set by national guidelines.

Cohort undergoing rehabilitation

Eligibility Criteria

• Age: 16 Years+
• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with Disorder Of Consciousness (DOC) who had attended an inpatient neurorehabilitation program between February 2004 and December 2021 in three facilities of the same hospital network were retrospectively extracted from their medical records.

You may qualify if:

• diagnosis with (Unresponsive Wakefulness Syndrome) UWS or Minimal Consciousness State (MCS) due to either a vascular, anoxic or traumatic origin

You may not qualify if:

• individuals who did not attended the program for at least three months

Sponsors & Collaborators

• Hospitales Nisa: lead

Study Sites (2)

Hospitales NISA

Valencia, 46011, Spain

Location

Servicio de Neurorrehabilitación y Daño Cerebral de los Hospitales NISA

Valencia, 46011, Spain

Location

Related Publications (26)

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• 'CRSR_GeneralGuidelines_20200812_v1.pdf'. Accessed: Jun. 09, 2022. [Online]. Available: https://www.sralab.org/sites/default/files/downloads/2020-09/CRSR_GeneralGuidelines_20200812_v1.pdf

  BACKGROUND

• J. T. Giacino, 'COMA RECOVERY SCALE-REVISED ©2004', p. 17, 2020.

  BACKGROUND

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  BACKGROUND

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MeSH Terms

Conditions

Consciousness Disorders; Persistent Vegetative State; Brain Injuries

Interventions

Rehabilitation

Condition Hierarchy (Ancestors)

Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Neurocognitive Disorders; Mental Disorders; Brain Damage, Chronic; Brain Diseases; Central Nervous System Diseases; Unconsciousness; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries

Intervention Hierarchy (Ancestors)

Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Health Services; Health Care Facilities Workforce and Services

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 9, 2023
• First Posted: April 19, 2023
• Study Start: February 1, 2004
• Primary Completion: December 31, 2021
• Study Completion: December 31, 2021
• Last Updated: April 19, 2023

Record last verified: 2023-04

Locations

ES (2)